CAS No. 128517-07-7
Batch:
Purity:99.78
Chemical Structure
Check the
Romidepsin (FK228)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (1S,4S,7Z,10S,16E,21R)-7-ethylidene-4,21-di(propan-2-yl)-2-oxa-12,13-dithia-5,8,20,23-tetrazabicyclo[8.7.6]tricos-16-ene-3,6,9,19,22-pentone | |
|---|---|---|
| CAS Number | 128517-07-7 | |
| Molecular Formula |
C24H36N4O6S2 |
|
| Molecular Weight (MW) | 540.7 | |
| SMILES | CC=C1C(=O)NC(C(=O)OC2CC(=O)NC(C(=O)NC(CSSCCC=C2)C(=O)N1)C(C)C)C(C)C | |
| InChIKey | OHRURASPPZQGQM-GCCNXGTGSA-N |
Romidepsin (FK228) is a potent histone deacetylase inhibitor targeting HDAC1 and HDAC2. It functions as a prodrug that is reduced intracellularly to an active form containing a free thiol group, which interacts with zinc in the HDAC active site. Romidepsin induces G1 and G2/M cell cycle arrest, promotes apoptosis, and exerts strong antitumor activity in various cancer models. [1]
|
Concentration
Volume
Mass
|
1 mg | 5 mg | 10 mg |
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
10 mg/mL
(18.49 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
100 mg/mL
(184.94 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
100 mg/mL
(184.94 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
100 mg/mL
(184.94 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
100 mg/mL
(184.94 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- Romidepsin (FK228) Mechanism of Action: HDAC Inhibition in T Lymphocyte Research
- Romidepsin (FK228) Clinical Trials
- Romidepsin (FK228) Working Concentration | Cell Culture | Treatment
- Romidepsin (FK228) Solubility in DMSO
- Romidepsin (FK228) Stock Solution
- Romidepsin (FK228) Storage
- Romidepsin (FK228) Stability
- Romidepsin (FK228) Combination Database
- Romidepsin (FK228) Molecular Weight
- Romidepsin (FK228) SMILES
- Romidepsin (FK228) Chemical Structure (2D and 3D)
- Romidepsin (FK228) IC50 for Cell-based and Cell-free Assays
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- Romidepsin (FK228) SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.