CAS No. 847925-91-1

Batch: Purity:99.77
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RO4929097 (RG-4733) Chemical Structure
Chemical Structure
Check the RO4929097 (RG-4733) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 2,2-dimethyl-N-[(7S)-6-oxo-5,7-dihydrobenzo[d][1]benzazepin-7-yl]-N'-(2,2,3,3,3-pentafluoropropyl)propanediamide
CAS Number 847925-91-1
Molecular Formula

C22H20F5N3O3
Molecular Weight (MW) 469.4
SMILES CC(C)(C(=O)NCC(C(F)(F)F)(F)F)C(=O)NC1C2=CC=CC=C2C3=CC=CC=C3NC1=O
InChIKey OJPLJFIFUQPSJR-INIZCTEOSA-N

Biological Activity

RO4929097 is an orally bioavailable, potent small-molecule γ-secretase inhibitor that blocks the proteolytic processing and activation of Notch receptors. By inhibiting γ-secretase, RO4929097 prevents the cleavage and release of the intracellular Notch domain, downregulating expression of downstream transcriptional targets such as Hes1. This inhibition disrupts canonical Notch pathway signaling, ultimately suppressing tumor cell proliferation and promoting a less transformed, slower-growing cellular phenotype. [1]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 94 mg/mL (200.25 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 50 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Reference

[1] Kopan R, et al. Cell. 2009;137(2):216-33.

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Note: Technical data last updated: Sep 1, 2026.