Clinical Trials

Regorafenib is supported by numerous clinical trials evaluating its therapeutic profile across Phase I through Phase IV protocols and real-world observational studies. Spanning active, recruiting, and completed stages, these studies focus on indications such as metastatic colorectal cancer, advanced gastrointestinal stromal tumors, hepatocellular carcinoma, and melanoma. Trial sponsorship is driven by pharmaceutical industry leaders like Bayer alongside major healthcare and academic centers, including Universitair Ziekenhuis Brussel and Centre Hospitalier Universitaire de Besancon.

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06087263 ACTIVE_NOT_RECRUITING
Gastrointestinal Stromal Tumors
M.D. Anderson Cancer Center
 2024-06-18 PHASE2
NCT07766772 NOT_YET_RECRUITING
HER2 + Breast Cancer; Advanced Breast Cancer
Fujian Cancer Hospital
 2026-09-30 PHASE2
NCT06902246 WITHDRAWN
Unresectable Hepatocellular Carcinoma; Hepatocellular Carcinoma
University of Miami
 2026-08-01 PHASE2
NCT06454409 SUSPENDED
Myelodysplastic Syndrome/Acute Myeloid Leukemia; Recurrent Acute Myeloid Leukemia; Recurrent Myelodysplastic Syndrome; Refractory Acute Myeloid Leukemia; Refractory Myelodysplastic Syndrome
City of Hope Medical Center
 2025-05-21 PHASE1
NCT04625907 RECRUITING
Rhabdomyosarcoma
University of Birmingham
 2020-09-17 PHASE1; PHASE2
NCT07392866 NOT_YET_RECRUITING
Hepatocellular Carcinoma (HCC)
Nanjing Sanhome Pharmaceutical, Co., Ltd.
 2026-03-01 PHASE2; PHASE3
NCT05462613 RECRUITING
Metastatic Colorectal Cancer
Centre Hospitalier Universitaire de Besancon
 2023-05-09 PHASE2; PHASE3
NCT07328009 RECRUITING
Hepato Cellular Carcinoma (HCC)
Fudan University
 2026-01-19 PHASE2
NCT06887218 RECRUITING
Metastatic Colorectal Cancer (CRC)
The Methodist Hospital Research Institute
 2025-05-08 PHASE2
NCT03844620 ACTIVE_NOT_RECRUITING
Refractory Colorectal Carcinoma; Stage III Colorectal Cancer AJCC v8; Stage IIIA Colorectal Cancer AJCC v8; Stage IIIB Colorectal Cancer AJCC v8; Stage IIIC Colorectal Cancer AJCC v8; Stage IV Colorectal Cancer AJCC v8; Stage IVA Colorectal Cancer AJCC v8; Stage IVB Colorectal Cancer AJCC v8; Stage IVC Colorectal Cancer AJCC v8
M.D. Anderson Cancer Center
 2019-01-29 PHASE2
NCT07379047 RECRUITING
GIST - Gastrointestinal Stromal Tumor; Advanced
Ningbo Newbay Technology Development Co., Ltd
 2026-05-11 PHASE2; PHASE3
NCT03970447 RECRUITING
Glioblastoma
Global Coalition for Adaptive Research
 2019-07-30 PHASE2; PHASE3
NCT07514429 NOT_YET_RECRUITING
Carcinoma, Hepatocellular; Lenvatinib; Treatment Failure
Ju Hyun Shim
 2026-03-15 PHASE2
NCT07514455 NOT_YET_RECRUITING
Carcinoma, Hepatocellular; Hepatic Insufficien; Disease Progression; Treatment Failure
Ju Hyun Shim
 2026-03-15 PHASE2
NCT06246643 ACTIVE_NOT_RECRUITING
Solid Malignant Tumors
Bayer
 2024-01-24 PHASE2
NCT07495579 NOT_YET_RECRUITING
Hepatocellular Carcinoma (HCC)
Asan Medical Center
 2026-04 PHASE2
NCT07096609 RECRUITING
GIST
Asan Medical Center
 2025-10-29 PHASE1; PHASE2
NCT07750041 NOT_YET_RECRUITING
Unresectable Advanced or Metastatic Colorectal Cancer
CSPC Megalith Biopharmaceutical Co.,Ltd.
 2026-08-30 PHASE1; PHASE2
NCT06992648 RECRUITING
Colorectal Cancer Metastatic; Colorectal Cancer Recurrent
Second Affiliated Hospital, Zhejiang University, School of Medicine
 2025-04-01 PHASE3
NCT07148427 NOT_YET_RECRUITING
Gastric/Gastroesophageal Junction Adenocarcinoma
The First Affiliated Hospital with Nanjing Medical University
 2025-09-20 PHASE2
NCT07689201 NOT_YET_RECRUITING
Gastrointestinal Neoplasms
GlaxoSmithKline
 2026-08-31 PHASE2
NCT06283134 NOT_YET_RECRUITING
Colorectal Cancer Metastatic
China Medical University, China
 2026-03 PHASE1
NCT07730489 NOT_YET_RECRUITING
Colorectal Cancer
Sichuan Baili Pharmaceutical Co., Ltd.
 2026-08 PHASE3
NCT07343791 RECRUITING
DC-CIK Treatment; Regorafenib; Colorectal Cancer; Immune Combination Therapy; Iparomlimab and Tuvonralimab Injection
JIANG LONGWEI
 2025-11-19 EARLY_PHASE1
NCT07384377 NOT_YET_RECRUITING
HER2-positive Colorectal Cancer
Shanghai JMT-Bio Inc.
 2026-02-06 PHASE3
NCT07310173 RECRUITING
HCC - Hepatocellular Carcinoma
Zhejiang Hisun Pharmaceutical Co. Ltd.
 2026-01-01 PHASE2
NCT02955940 ACTIVE_NOT_RECRUITING
Pancreatic Cancer; Colorectal Cancer (CRC); Breast Cancer; Lung Cancer
Incyte Corporation
 2016-11-30 PHASE2
NCT02925234 RECRUITING
Cancer; Tumors; Neoplasm; Neoplasia
The Netherlands Cancer Institute
 2016-08 PHASE2
NCT05608044 ACTIVE_NOT_RECRUITING
Metastatic Colorectal Cancer
Agenus Inc.
 2022-11-30 PHASE2
NCT06425133 RECRUITING
Metastatic Colorectal Cancer
Centre Hospitalier Universitaire de Besancon
 2024-07-19 PHASE2
NCT05905887 RECRUITING
Gastrointestinal Stromal Tumors
Asan Medical Center
 2023-09-06 PHASE2
NCT07115550 NOT_YET_RECRUITING
Hepatocellular Carcinoma (HCC)
Huai'an First People's Hospital
 2025-08-26
NCT07100392 RECRUITING
Hepatocellular Carcinoma (HCC)
Fudan University
 2025-08-14 PHASE2
NCT07483684 NOT_YET_RECRUITING
HER2 IHC3+ Advanced Colorectal Cancer
Chia Tai Tianqing Pharmaceutical Group Nanjing Shunxin Pharmaceutical Co., Ltd.
 2026-03 PHASE3
NCT06772233 NOT_YET_RECRUITING
Metastatic Gastrointestinal Stromal Tumors (GIST)
Peking University
 2025-07-30 PHASE2
NCT07134205 NOT_YET_RECRUITING
Metastatic Colorectal Cancer (mCRC)
Shanghai JMT-Bio Inc.
 2025-10-01 PHASE3
NCT07559864 RECRUITING
GIST - Gastrointestinal Stromal Tumor; KIT Gene Mutation
Jian Li
 2025-07-14 PHASE2
NCT06946849 NOT_YET_RECRUITING
Intrahepatic Cholangiocarcinoma (Icc)
Shanghai Zhongshan Hospital
 2025-06-01 PHASE2
NCT07040228 RECRUITING
Pancreatic Cancer Metastatic
Junjie Hang
 2025-05-26 PHASE1; PHASE2
NCT07003022 RECRUITING
Colo-rectal Cancer; MSIhi or dMMR Advanced Unresectable or Metastatic Solid Tumors, Including Colorectal Cancers
Fudan University
 2025-06-01 PHASE2
NCT07071961 RECRUITING
Colorectal Cancer; Regorafenib; High Risk Patients
M.D. Anderson Cancer Center
 2026-02-11 PHASE2
NCT06930118 RECRUITING
Advanced Colorectal Cancer in the Third-line Treatment and Beyond; pMMR/MSS Advanced Colorectal Cancer
Shanghai Changzheng Hospital
 2025-04-10 PHASE2
NCT06949982 RECRUITING
Metastatic Colorectal Cancer (mCRC); Colorectal Neoplasms
Sergey Orlov, MD
 2025-03-17 PHASE2
NCT05830084 ACTIVE_NOT_RECRUITING
Ewing Sarcoma
Gustave Roussy, Cancer Campus, Grand Paris
 2023-06-16 PHASE1
NCT06326346 RECRUITING
Gastrointestinal Stromal Tumors
Asan Medical Center
 2024-11-20 PHASE2
NCT05794971 RECRUITING
Colorectal Cancer Liver Metastases; Regorafenib
Sun Yat-sen University
 2023-06-10 PHASE3
NCT04701476 RECRUITING
Colorectal Cancer; Lung Cancer
Teclison Ltd.
 2021-05-20 PHASE2
NCT06558773 RECRUITING
Colorectal Cancer
Chinese PLA General Hospital
 2026-03-01 PHASE2
NCT06047379 RECRUITING
Diffuse Astrocytoma, IDH-Mutant; Glioblastoma, IDH-wildtype; Brain Metastases, Adult; Cervical Cancer; Colorectal Cancer; Esophageal Cancer; Esophageal Squamous Cell Carcinoma; Gastric Cancer; Gastroesophageal Junction Adenocarcinoma; Head and Neck Squamous Cell Carcinoma; Melanoma; Merkel Cell Carcinoma; Microsatellite Instability-High Solid Malignant Tumor; Mismatch Repair Deficient Solid Malignant Tumor; Microsatellite Instability-High Colorectal Cancer; Mismatch Repair Deficient Colorectal Cancer; Non-small Cell Lung Cancer; Renal Cell Carcinoma; Small Cell Lung Cancer; Squamous Cell Carcinoma; Urothelial Carcinoma
Neonc Technologies, Inc.
 2023-11-01 PHASE1; PHASE2
NCT07300488 ACTIVE_NOT_RECRUITING
HCC
Xi'an Xintong Pharmaceutical Research Co.,Ltd.
 2025-09-01 PHASE2; PHASE3
NCT04757363 ACTIVE_NOT_RECRUITING
Esophagogastric Cancer; HER2-Negative
Memorial Sloan Kettering Cancer Center
 2021-02-11 PHASE2
NCT06575725 WITHDRAWN
Advanced Colon Adenocarcinoma; Advanced Colorectal Adenocarcinoma; Advanced Rectal Adenocarcinoma; Metastatic Colon Adenocarcinoma; Metastatic Colorectal Adenocarcinoma; Metastatic Rectal Adenocarcinoma; Stage III Colon Cancer AJCC v8; Stage III Colorectal Cancer AJCC v8; Stage III Rectal Cancer AJCC v8; Stage IV Colon Cancer AJCC v8; Stage IV Colorectal Cancer AJCC v8; Stage IV Rectal Cancer AJCC v8
City of Hope Medical Center
 2024-11-01 PHASE2
NCT05985109 RECRUITING
Colorectal Cancer
Peking University Cancer Hospital & Institute
 2023-10-26 PHASE2
NCT05366816 RECRUITING
Gastrointestinal Stromal Tumors
University of Miami
 2023-10-17 PHASE2
NCT06099821 RECRUITING
Digestive System Cancers
Peking University Cancer Hospital & Institute
 2023-10-25 PHASE2
NCT07567222 RECRUITING
Malignant Tumor
West China Hospital
 2026-06-05 PHASE1
NCT04503694 ACTIVE_NOT_RECRUITING
Rectal Cancer Stage II; Rectal Cancer Stage III
Jules Bordet Institute
 2021-03-25 PHASE2
NCT06275919 RECRUITING
Meningioma, Malignant
Istituto Oncologico Veneto IRCCS
 2024-09-23 PHASE2
NCT05159245 RECRUITING
Advanced Cancer; Solid Tumor; Haematological Malignancy
Helsinki University Central Hospital
 2021-12-10 PHASE2
NCT05622136 ACTIVE_NOT_RECRUITING
Liver Cancer; Hepatocellular Carcinoma
Instituto do Cancer do Estado de São Paulo
 2023-09-10 PHASE2
NCT06682611 NOT_YET_RECRUITING
Unresectable Locally Advanced or Metastatic Solid Tumors
Shanghai Runshi Pharmaceutical Technology Co., Ltd
 2024-11-13 PHASE1; PHASE2
NCT07501351 RECRUITING
Hepatocellulcar Carcinoma
Sun Yat-sen University
 2026-01-05 PHASE2
NCT04055220 RECRUITING
Bone Sarcoma; Osteosarcoma; Ewing Sarcoma; Chondrosarcoma; Undifferentiated Pleomorphic Sarcoma; Leiomyosarcoma; Angiosarcoma
Centre Leon Berard
 2020-03-03
NCT04116541 RECRUITING
Malignant Solid Tumor
Centre Leon Berard
 2020-01-28 PHASE2
NCT07213570 RECRUITING
Colorectal Cancer Metastatic
National Cancer Institute, Naples
 2025-10-16 PHASE2
NCT05057052 RECRUITING
Liver Metastases; Colorectal Cancer Metastatic
Fudan University
 2021-09-26 PHASE2
NCT05113368 RECRUITING
Ovarian Cancer; Serous Ovarian Cancer
Sarah K. Lynam MD
 2022-06-28 PHASE2
NCT07078305 NOT_YET_RECRUITING
Hepatocellular Carcinoma
Tianjin Medical University Cancer Institute and Hospital
 2025-08 PHASE2
NCT04698785 RECRUITING
Bone Sarcoma; Osteosarcoma
Centre Leon Berard
 2021-07-21 PHASE2
NCT06820957 ACTIVE_NOT_RECRUITING
CIC-Rearranged Sarcoma; Metastatic Ewing Sarcoma; Metastatic High Grade Sarcoma; Metastatic Undifferentiated Round Cell Sarcoma; Metastatic Undifferentiated Sarcoma, Not Otherwise Specified; Round Cell Sarcoma With EWSR1-non-ETS Fusion; Sarcoma With BCOR Genetic Alterations
Children's Oncology Group
 2025-11-10 PHASE2; PHASE3
NCT05425940 ACTIVE_NOT_RECRUITING
Colorectal Cancer
Exelixis
 2022-09-07 PHASE3
NCT05155189 RECRUITING
Hepatocellular Carcinoma
Zhejiang University
 2022-02-21 PHASE1
NCT06911684 RECRUITING
Rectal Cancer Patients
Sun Yat-sen University
 2025-04-30 PHASE2
NCT06375317 NOT_YET_RECRUITING
HCC - Hepatocellular Carcinoma
Yehua Shen
 2024-04-30 PHASE2
NCT05672316 ACTIVE_NOT_RECRUITING
Advanced Colorectal Adenocarcinoma; Advanced Microsatellite Stable Colorectal Carcinoma; Metastatic Colorectal Adenocarcinoma; Metastatic Microsatellite Stable Colorectal Carcinoma; Stage III Colorectal Cancer AJCC v8; Stage IV Colorectal Cancer AJCC v8
City of Hope Medical Center
 2023-05-11 PHASE1; PHASE2
NCT06199973 ACTIVE_NOT_RECRUITING
Advanced Colorectal Cancer
Suzhou Suncadia Biopharmaceuticals Co., Ltd.
 2024-03-01 PHASE3
NCT06280105 RECRUITING
Hepatocellular Carcinoma
Meng Chao Hepatobiliary Hospital of Fujian Medical University
 2024-03-31 PHASE2
NCT05773105 COMPLETED
Advanced Hepatocellular Carcinoma
Sun Yat-sen University
 2023-09-19 PHASE1; PHASE2
NCT06456515 RECRUITING
Colorectal Cancer Metastatic
The First People's Hospital of Changzhou
 2024-05-01
NCT04777851 TERMINATED
Carcinoma, Hepatocellular
Translational Research in Oncology
 2023-10-11 PHASE3
NCT07223567 WITHDRAWN
Rectal Cancer; Rectal Cancer Recurrent
M.D. Anderson Cancer Center
 2025-10-27 PHASE2
NCT07137390 WITHDRAWN
Colorectal Cancer
M.D. Anderson Cancer Center
 2025-09-03 PHASE1; PHASE2
NCT06071052 COMPLETED
Liver Metastasis Colon Cancer
First Affiliated Hospital, Sun Yat-Sen University
 2023-12-01 PHASE2
NCT03899428 RECRUITING
Hepatocellular Carcinoma
Humanity & Health Medical Group Limited
 2019-05-02 PHASE2
NCT06829355 RECRUITING
MCRC
Beijing Friendship Hospital
 2025-02-11 PHASE2
NCT05917431 RECRUITING
Unresectable Hepatocellular Carcinoma; Oligometastatic Disease
Peking University Cancer Hospital & Institute
 2023-06 PHASE2
NCT04362839 COMPLETED
Advanced Colon Adenocarcinoma; Metastatic Colon Adenocarcinoma; Metastatic Colorectal Adenocarcinoma; Metastatic Colorectal Carcinoma; Metastatic Rectal Adenocarcinoma; Stage III Colon Cancer AJCC v8; Stage III Rectal Cancer AJCC v8; Stage IIIA Colon Cancer AJCC v8; Stage IIIA Rectal Cancer AJCC v8; Stage IIIB Colon Cancer AJCC v8; Stage IIIB Rectal Cancer AJCC v8; Stage IIIC Colon Cancer AJCC v8; Stage IIIC Rectal Cancer AJCC v8; Stage IV Colon Cancer AJCC v8; Stage IV Colorectal Cancer AJCC v8; Stage IV Rectal Cancer AJCC v8; Stage IVA Colon Cancer AJCC v8; Stage IVA Colorectal Cancer AJCC v8; Stage IVA Rectal Cancer AJCC v8; Stage IVB Colon Cancer AJCC v8; Stage IVB Colorectal Cancer AJCC v8; Stage IVB Rectal Cancer AJCC v8; Stage IVC Colon Cancer AJCC v8; Stage IVC Colorectal Cancer AJCC v8; Stage IVC Rectal Cancer AJCC v8
City of Hope Medical Center
 2020-05-27 PHASE1
NCT05194293 ACTIVE_NOT_RECRUITING
Stage IB Hepatocellular Carcinoma AJCC v8; Stage II Hepatocellular Carcinoma AJCC v8; Stage III Hepatocellular Carcinoma AJCC v8; Stage IIIA Hepatocellular Carcinoma AJCC v8
Academic and Community Cancer Research United
 2023-07-01 PHASE2
NCT06455254 UNKNOWN
CRC
Jin-hong Chen
 2024-07-11 PHASE2
NCT06543836 UNKNOWN
Metastatic Colorectal Cancer
Cancer Institute and Hospital, Chinese Academy of Medical Sciences
 2023-12-01 PHASE2
NCT06283303 UNKNOWN
Colorectal Cancer Metastatic
China Medical University, China
 2024-04-02 PHASE1
NCT05644392 UNKNOWN
Advanced Biliary Systemic Tumours That Has Failed at Least One Prior Systemic Therapy
Tianjin Medical University Cancer Institute and Hospital
 2022-11-25 PHASE1
NCT04781192 ACTIVE_NOT_RECRUITING
Advanced Biliary Tract Cancer
University of Kansas Medical Center
 2022-03-22 PHASE1; PHASE2
NCT05048017 UNKNOWN
Hepatocellular Carcinoma; Regorafenib; PD-1 Inhibitor
Peking Union Medical College Hospital
 2021-10-01 PHASE2
NCT05644379 ACTIVE_NOT_RECRUITING
Advanced Hepatocellular Carcinoma That Has Failed at Least One Prior Systemic Therapy
Tianjin Medical University Cancer Institute and Hospital
 2022-11-24 PHASE1
NCT04803877 ACTIVE_NOT_RECRUITING
Osteosarcoma; Osteosarcoma in Children; Osteosarcoma Recurrent; Osteosarcoma Metastatic
Sarcoma Alliance for Research through Collaboration
 2021-06-04 PHASE2
NCT07619937 COMPLETED
Cholangiocarcinoma
The First Affiliated Hospital of Zhengzhou University
 2022-07-22 PHASE2
NCT05933980 UNKNOWN
Colorectal Cancer; Liver Metastases; MSS
Sun Yat-sen University
 2023-12-19 PHASE2
NCT05395741 COMPLETED
Osteosarcoma; Ewing Sarcoma of Bone
Institute of Mother and Child, Warsaw, Poland
 2022-04-28 PHASE1; PHASE2
NCT04660812 COMPLETED
Metastatic Colorectal Cancer
Arcus Biosciences, Inc.
 2021-05-10 PHASE1; PHASE2
NCT06856590 COMPLETED
Hand-Foot Skin Reaction (HFSR)
Gazi University
 2025-02-20
NCT02023333 COMPLETED
Metastatic Colorectal Adenocarcinoma
Memorial Sloan Kettering Cancer Center
 2013-12-10 PHASE2
NCT04787341 COMPLETED
Colorectal Cancer
Gruppo Oncologico del Nord-Ovest
 2020-12-15 PHASE2
NCT05962450 UNKNOWN
Hepatocellular Carcinoma
Beijing YouAn Hospital
 2023-10-26 PHASE2
NCT07537985 COMPLETED
Hepatocellulcar Carcinoma
Sun Yat-sen University
 2020-01-01
NCT05198934 COMPLETED
Colorectal Cancer (CRC)
Amgen
 2022-04-19 PHASE3
NCT05328908 TERMINATED
Colorectal Neoplasms
Bristol-Myers Squibb
 2022-04-28 PHASE3
NCT06006923 TERMINATED
MSI-H Colorectal Cancer
Anwaar Saeed
 2024-06-26 PHASE2
NCT05970705 UNKNOWN
Metastatic Colorectal Cancer
Fudan University
 2023-07-01 PHASE2
NCT05426811 UNKNOWN
Regorafenib; Raltitrexed; Colorectal Neoplasms; Third-line Treatment
China Medical University, China
 2022-07-01 PHASE1; PHASE2
NCT06335927 UNKNOWN
Intrahepatic Cholangiocarcinoma
Fudan University
 2023-05-11 PHASE2
NCT05582031 WITHDRAWN
Anal Squamous Cell Carcinoma; Colorectal Neoplasms; Soft Tissue Sarcoma; Malignant Pleural Mesothelioma; Small Cell Lung Carcinoma; Castrate Resistant Prostate Cancer; Neuroendocrine Carcinoma of Prostate; Gastroenteropancreatic Neuroendocrine Neoplasm
Translational Research in Oncology
 2023-04-30 PHASE2
NCT05963490 RECRUITING
Microsatellite Stable Metastatic Colorectal Cancer
Fudan University
 2023-04-25 PHASE2
NCT04874207 COMPLETED
Colorectal Cancer Metastatic
Rennes University Hospital
 2021-10-22 PHASE4
NCT06322563 UNKNOWN
Advanced/Metastatic Colorectal Cancer
Tianjin Medical University Cancer Institute and Hospital
 2024-04-01 PHASE2
NCT05818267 UNKNOWN
Colorectal Cancer
Wei Zhang
 2023-06-26
NCT02934529 COMPLETED
Metastatic Colorectal Cancer
Ludwig-Maximilians - University of Munich
 2015-03 PHASE3
NCT05770882 TERMINATED
Hepatocellular Carcinoma (HCC)
Great Novel Therapeutics Biotech & Medicals Corporation
 2023-04-25 PHASE1; PHASE2
NCT04879368 COMPLETED
Gastro-Oesophageal Cancer
Australasian Gastro-Intestinal Trials Group
 2021-05-05 PHASE3
NCT03944304 COMPLETED
Gastrointestinal Stromal Tumors
Asan Medical Center
 2019-05-27 PHASE2
NCT03475953 UNKNOWN
Colorectal Cancer Not MSI-H or MMR-deficient; GIST; Oesophageal or Gastric Carcinoma; Biliary Tract Cancer; Hepatocellular Carcinoma; Soft-tissue Sarcoma; Thyroid Cancer; Gastro-enteropancreatic Neuroendocrine Tumor; Non-small Cell Lung Cancer; Solid Tumor, Adult; Urothelial Carcinoma; HPV-Related Carcinoma; Triple Negative Breast Cancer; Renal Carcinoma; Mesotheliomas Pleural
Institut Bergonié
 2018-05-04 PHASE1; PHASE2
NCT05370807 UNKNOWN
Melanoma Stage III; Melanoma Stage IV
Universitair Ziekenhuis Brussel
 2022-10-03 PHASE2
NCT02098538 COMPLETED
Adenoid Cystic Carcinoma
Memorial Sloan Kettering Cancer Center
 2014-03 PHASE2
NCT03377361 COMPLETED
Colorectal Cancer; Colorectal Tumors; Colorectal Carcinoma; Colorectal Neoplasm
Bristol-Myers Squibb
 2018-01-31 PHASE1; PHASE2
NCT06200363 UNKNOWN
Advanced Colorectal Cancer
West China Hospital
 2023-09-21 PHASE1
NCT02619435 UNKNOWN
Advanced Colorectal Cancer
National Cancer Institute, Naples
 2015-11 PHASE2
NCT05134532 UNKNOWN
Hepatocellular Carcinoma
CHA University
 2021-12-24 PHASE2
NCT02389244 COMPLETED
Ewing Sarcomas; Chondrosarcomas; Osteosarcomas; Chondroma; CIC-Rearranged Sarcoma
UNICANCER
 2014-09 PHASE2
NCT06095375 COMPLETED
Glioblastoma, IDH-wildtype; MGMT-Methylated Glioblastoma
Istituto Oncologico Veneto IRCCS
 2022-07-04 PHASE1
NCT05759195 COMPLETED
Glioblastoma; Glioblastoma, IDH-wildtype
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
 2021-01-07
NCT04776148 COMPLETED
Colorectal Neoplasms
Merck Sharp & Dohme LLC
 2021-03-29 PHASE3
NCT05535647 UNKNOWN
Intrahepatic Cholangiocarcinoma
Tianjin Medical University Cancer Institute and Hospital
 2022-09-25 PHASE2
NCT03829462 ACTIVE_NOT_RECRUITING
Metastatic Colorectal Cancer (mCRC)
Institut du Cancer de Montpellier - Val d'Aurelle
 2019-03-28 PHASE3
NCT05820906 UNKNOWN
Advanced Biliary Tract Cancer
Tianjin Medical University Cancer Institute and Hospital
 2023-09-01 PHASE2
NCT03994601 COMPLETED
Advanced Cancer
Bristol-Myers Squibb
 2019-09-06 PHASE1; PHASE2
NCT05064059 COMPLETED
Colorectal Cancer
Merck Sharp & Dohme LLC
 2021-11-10 PHASE3
NCT05600309 COMPLETED
Colorectal Cancer
Merck Sharp & Dohme LLC
 2022-06-14 PHASE3
NCT05877001 UNKNOWN
Colorectal Liver Metastases
Peking University Cancer Hospital & Institute
 2023-05-30 PHASE2
NCT04170556 COMPLETED
Hepatocellular Carcinoma
Fundacion Clinic per a la Recerca Biomédica
 2020-03-16 PHASE1; PHASE2
NCT06089330 UNKNOWN
Metastatic Colorectal Cancer (mCRC)
Shanghai JMT-Bio Inc.
 2024-01 PHASE2
NCT05894837 UNKNOWN
Colorectal Cancer; Liver Metastases
Second Affiliated Hospital, Zhejiang University, School of Medicine
 2023-06-01 PHASE2
NCT04327700 TERMINATED
Hepatocellular Carcinoma
Wake Forest University Health Sciences
 2021-01-26 PHASE2
NCT05394740 COMPLETED
Gastric Adenocarcinoma; Gastroesophageal Junction Adenocarcinoma; Esophageal Adenocarcinoma
National Cancer Center Hospital East
 2022-06-06 PHASE1; PHASE2
NCT04450836 TERMINATED
Metastatic Colorectal Cancer
UNICANCER
 2020-11-23 PHASE2
NCT04051606 COMPLETED
Recurrent Glioblastoma
Case Comprehensive Cancer Center
 2019-07-31 PHASE2
NCT03793361 COMPLETED
Metastatic Soft Tissue Sarcoma
Centre Oscar Lambret
 2019-05-15 PHASE2
NCT05382741 UNKNOWN
Colorectal Cancer Stage IV; No Evidence of Disease State
Ospedale Policlinico San Martino
 2022-03-02 PHASE2
NCT04183088 UNKNOWN
Advanced Hepatocellular Carcinoma
National Taiwan University Hospital
 2020-12-16 PHASE2
NCT06321055 Not yet recruiting
Advanced Gastrointestinal Stromal Tumor
Bayer
 2024-03-20 --
NCT06137170 Active not recruiting
Metastatic Colorectal Cancer
Bayer
 2024-03-01 --
NCT05524155 UNKNOWN
Colorectal Cancer; Liver Metastasis
Tianjin Medical University Cancer Institute and Hospital
 2022-09 PHASE2
NCT05753163 UNKNOWN
Colorectal Liver Metastasis
Fudan University
 2022-08-02 PHASE2
NCT05900648 WITHDRAWN
Colorectal Cancer; Colon Cancer; Rectum Cancer
M.D. Anderson Cancer Center
 2023-05-17 PHASE2
NCT02365441 UNKNOWN
Gastrointestinal Stromal Tumour
Australasian Gastro-Intestinal Trials Group
 2015-06-30 PHASE2
NCT04534218 COMPLETED
Colo-rectal Cancer; Metastatic Cancer
Centre Hospitalier Universitaire de Besancon
 2020-10-16 PHASE2
NCT03992456 UNKNOWN
Metastatic Colon Adenocarcinoma; Metastatic Colorectal Carcinoma; Metastatic Rectal Adenocarcinoma; Stage III Colon Cancer AJCC v8; Stage III Colorectal Cancer AJCC v8; Stage III Rectal Cancer AJCC v8; Stage IIIA Colon Cancer AJCC v8; Stage IIIA Colorectal Cancer AJCC v8; Stage IIIA Rectal Cancer AJCC v8; Stage IIIB Colon Cancer AJCC v8; Stage IIIB Colorectal Cancer AJCC v8; Stage IIIB Rectal Cancer AJCC v8; Stage IIIC Colon Cancer AJCC v8; Stage IIIC Colorectal Cancer AJCC v8; Stage IIIC Rectal Cancer AJCC v8; Stage IV Colon Cancer AJCC v8; Stage IV Colorectal Cancer AJCC v8; Stage IV Rectal Cancer AJCC v8; Stage IVA Colon Cancer AJCC v8; Stage IVA Colorectal Cancer AJCC v8; Stage IVA Rectal Cancer AJCC v8; Stage IVB Colon Cancer AJCC v8; Stage IVB Colorectal Cancer AJCC v8; Stage IVB Rectal Cancer AJCC v8; Stage IVC Colon Cancer AJCC v8; Stage IVC Colorectal Cancer AJCC v8; Stage IVC Rectal Cancer AJCC v8; Unresectable Colon Adenocarcinoma; Unresectable Colorectal Carcinoma; Unresectable Rectal Adenocarcinoma
Academic and Community Cancer Research United
 2020-04-24 PHASE2
NCT04117945 ACTIVE_NOT_RECRUITING
BRAF V600E Negative; KRAS Gene Mutation Negative; Locally Advanced Unresectable Colorectal Adenocarcinoma; Metastatic Colorectal Adenocarcinoma; NRAS Gene Mutation Negative; Stage III Colorectal Cancer AJCC v8; Stage IIIA Colorectal Cancer AJCC v8; Stage IIIB Colorectal Cancer AJCC v8; Stage IIIC Colorectal Cancer AJCC v8; Stage IV Colorectal Cancer AJCC v8; Stage IVA Colorectal Cancer AJCC v8; Stage IVB Colorectal Cancer AJCC v8; Stage IVC Colorectal Cancer AJCC v8
Academic and Community Cancer Research United
 2020-03-03 PHASE2
NCT02657551 COMPLETED
Thyroid Cancer
Dana-Farber Cancer Institute
 2016-01 PHASE2
NCT06029010 Completed
Metastatic Colorectal Cancer
Bayer
 2023-08-31 --
NCT05485909 UNKNOWN
Colorectal Cancer Liver Metastases
Sun Yat-sen University
 2022-07-25 PHASE2
NCT04718909 UNKNOWN
Hepatocellular Carcinoma Non-resectable
Second Affiliated Hospital of Guangzhou Medical University
 2021-01-09 PHASE2
NCT05730673 WITHDRAWN
CCR5; Microsatellite Stable; Metastatic; Colorectal Cancer
CytoDyn, Inc.
 2022-09-20 PHASE2
NCT03564938 COMPLETED
Metastatic Colorectal Cancer
Bayer
 2018-07-30 PHASE4
NCT04704154 COMPLETED
Solid Tumors
Bayer
 2021-02-03 PHASE2
NCT04008511 UNKNOWN
Metastatic Colorectal Cancer
China Medical University, China
 2019-07 PHASE1; PHASE2
NCT03890731 COMPLETED
Solid Cancer
Bayer
 2019-04-02 PHASE2
NCT03657641 ACTIVE_NOT_RECRUITING
Colorectal Cancer; Colorectal Cancer Metastatic
University of Southern California
 2019-06-21 PHASE1; PHASE2
NCT04030260 UNKNOWN
Colorectal Cancer Metastatic; MSS
Sun Yat-sen University
 2019-07-19 PHASE2
NCT05233358 UNKNOWN
Hepatocellular Carcinoma
The Central Hospital of Lishui City
 2022-02-01
NCT04745130 UNKNOWN
Sintilimab, Cetuximab, Regorafenib,Combine,mCRC
Tianjin Medical University Cancer Institute and Hospital
 2021-03-01 PHASE2
NCT05370807 Recruiting
Melanoma Stage III|Melanoma Stage IV
Universitair Ziekenhuis Brussel
 2022-10-03 Phase 2
NCT03555149 TERMINATED
Colorectal Cancer
Hoffmann-La Roche
 2018-09-27 PHASE1; PHASE2
NCT02795156 COMPLETED
Non-small Cell Lung Carcinoma; Urothelial Carcinoma; Gastrointestinal Carcinoma, Non-colon; Upper Aerodigestive Tract Carcinoma
SCRI Development Innovations, LLC
 2016-09-28 PHASE2
NCT05289726 UNKNOWN
Hand and Foot Skin Reaction; Colorectal Cancer Stage IV
Cancer Institute and Hospital, Chinese Academy of Medical Sciences
 2022-04-18 PHASE2
NCT03627728 COMPLETED
Gastric Cancer
Gruppo Oncologico Italiano di Ricerca Clinica
 2018-06-13 PHASE2
NCT03520842 COMPLETED
KRAS Gene Mutation; Metastatic Malignant Neoplasm in the Brain; Recurrent Non-Small Cell Lung Carcinoma; Stage IV Non-Small Cell Lung Cancer AJCC v7
Stanford University
 2018-08-14 PHASE2
NCT05130021 UNKNOWN
Metastatic Colorectal Cancer
Maxinovel Pty., Ltd.
 2022-01-31 PHASE2
NCT04310709 COMPLETED
Carcinoma, Hepatocellular; Hepatoma
Asan Medical Center
 2020-06-16 PHASE2
NCT03722108 TERMINATED
Adenocarcinoma of the Stomach; Adenocarcinoma of the Gastroesophageal Junction
UNICANCER
 2019-02-07 PHASE1; PHASE2
NCT04696055 COMPLETED
Hepatocellular Carcinoma
Bayer
 2021-02-03 PHASE2
NCT02048371 COMPLETED
Liposarcoma; Osteogenic Sarcoma; Ewing/Ewing-like Sarcoma; Rhabdomyosarcoma; Mesenchymal Chondrosarcoma
Sarcoma Alliance for Research through Collaboration
 2014-07 PHASE2
NCT02501551 UNKNOWN
Melanoma
Yonsei University
 2015-02 PHASE2
NCT04806243 UNKNOWN
Hepatocellular Carcinoma
Nanfang Hospital, Southern Medical University
 2021-05-06 PHASE2
NCT02773524 UNKNOWN
Gastro-Oesophageal Cancer
Australasian Gastro-Intestinal Trials Group
 2016-11 PHASE3
NCT02910843 TERMINATED
Rectal Cancer
Swiss Cancer Institute
 2017-02-22 PHASE1
NCT03956940 TERMINATED
Hepatocarcinoma
Institut du Cancer de Montpellier - Val d'Aurelle
 2019-10-04
NCT04985136 TERMINATED
Advanced Hepatocellular Carcinoma (HCC)
Jiangsu HengRui Medicine Co., Ltd.
 2021-09-26 PHASE3
NCT03828799 COMPLETED
Metastatic Colorectal Cancer
Institut du Cancer de Montpellier - Val d'Aurelle
 2019-05-14 PHASE1; PHASE2
NCT03609424 COMPLETED
Gastrointestinal Stromal Tumors
Asan Medical Center
 2019-02-14 PHASE1; PHASE2
NCT04476329 TERMINATED
Hepatocellular Carcinoma
SC Liver Research Consortium, LLC
 2021-01-21 PHASE2
NCT02584465 COMPLETED
Ovarian Carcinoma
ARCAGY/ GINECO GROUP
 2015-08-28 PHASE2
NCT03712943 COMPLETED
Colorectal Cancer; Metastatic Colorectal Cancer; Colon Cancer
H. Lee Moffitt Cancer Center and Research Institute
 2018-10-23 PHASE1
NCT03042689 COMPLETED
Acute Myeloid Leukemia
Massachusetts General Hospital
 2017-04-17 PHASE1
NCT02638766 COMPLETED
Gastrointestinal Stromal Tumors
Grupo Espanol de Investigacion en Sarcomas
 2015-11 PHASE2
NCT04110093 UNKNOWN
Colorectal Cancer; Immunotherapy
Shanghai Changzheng Hospital
 2019-03-01 PHASE1; PHASE2
NCT04071756 TERMINATED
Solid Tumor; Hand-Foot Skin Reaction (HFSR)
Dana-Farber Cancer Institute
 2019-12-30 PHASE2
NCT03475251 COMPLETED
Advanced Cancer
CStone Pharmaceuticals
 2018-05-09 PHASE1
NCT04200404 COMPLETED
Advanced Refractory Solid Tumors
CStone Pharmaceuticals
 2019-12-13 PHASE1; PHASE2
NCT03880877 UNKNOWN
Metastatic Colorectal Cancer
Kaohsiung Medical University Chung-Ho Memorial Hospital
 2019-02-26 PHASE2
NCT03347292 COMPLETED
Carcinoma, Hepatocellular
Bayer
 2018-06-18 PHASE1
NCT03406871 COMPLETED
Advanced and Metastatic Solid Tumor
Kohei Shitara
 2018-01-15 PHASE1
NCT03878524 TERMINATED
Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Anatomic Stage IV Breast Cancer AJCC v8; Anemia; Ann Arbor Stage III Hodgkin Lymphoma; Ann Arbor Stage III Non-Hodgkin Lymphoma; Ann Arbor Stage IV Hodgkin Lymphoma; Ann Arbor Stage IV Non-Hodgkin Lymphoma; Atypical Chronic Myeloid Leukemia, BCR-ABL1 Negative; Blast Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Castration-Resistant Prostate Carcinoma; Chronic Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Hematopoietic and Lymphoid System Neoplasm; Locally Advanced Pancreatic Adenocarcinoma; Metastatic Breast Carcinoma; Metastatic Malignant Solid Neoplasm; Metastatic Pancreatic Adenocarcinoma; Myelodysplastic/Myeloproliferative Neoplasm With Ring Sideroblasts and Thrombocytosis; Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable; Primary Myelofibrosis; Recurrent Acute Lymphoblastic Leukemia; Recurrent Acute Myeloid Leukemia; Recurrent Chronic Lymphocytic Leukemia; Recurrent Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Recurrent Hematologic Malignancy; Recurrent Hodgkin Lymphoma; Recurrent Myelodysplastic Syndrome; Recurrent Myelodysplastic/Myeloproliferative Neoplasm; Recurrent Myeloproliferative Neoplasm; Recurrent Non-Hodgkin Lymphoma; Recurrent Plasma Cell Myeloma; Recurrent Small Lymphocytic Lymphoma; Refractory Acute Lymphoblastic Leukemia; Refractory Acute Myeloid Leukemia; Refractory Chronic Lymphocytic Leukemia; Refractory Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Refractory Chronic Myelomonocytic Leukemia; Refractory Hematologic Malignancy; Refractory Hodgkin Lymphoma; Refractory Malignant Solid Neoplasm; Refractory Myelodysplastic Syndrome; Refractory Myelodysplastic/Myeloproliferative Neoplasm; Refractory Non-Hodgkin Lymphoma; Refractory Plasma Cell Myeloma; Refractory Primary Myelofibrosis; Refractory Small Lymphocytic Lymphoma; Stage II Pancreatic Cancer AJCC v8; Stage III Pancreatic Cancer AJCC v8; Stage IV Pancreatic Cancer AJCC v8; Stage IV Prostate Cancer AJCC v8; Unresectable Pancreatic Adenocarcinoma
OHSU Knight Cancer Institute
 2020-04-01 PHASE1
NCT04126733 COMPLETED
Colorectal Cancer
Bayer
 2019-10-14 PHASE2
NCT01900743 COMPLETED
Sarcoma
Centre Oscar Lambret
 2013-06-05 PHASE2
NCT02259725 COMPLETED
Gastrinoma; Glucagonoma; Insulinoma; Metastatic Gastrointestinal Carcinoid Tumor; Pancreatic Polypeptide Tumor; Pulmonary Carcinoid Tumor; Recurrent Gastrointestinal Carcinoid Tumor; Recurrent Islet Cell Carcinoma; Somatostatinoma
University of Southern California
 2016-08-16 PHASE2
NCT03099486 TERMINATED
Colorectal Cancer
Fox Chase Cancer Center
 2017-10-06 PHASE2
NCT03215264 COMPLETED
Colorectal Cancer
Abramson Cancer Center at Penn Medicine
 2017-10-02 PHASE1
NCT03946917 UNKNOWN
Colorectal Cancer
Sun Yat-sen University
 2019-03-12 PHASE1; PHASE2
NCT02095054 COMPLETED
Advanced Cancers
M.D. Anderson Cancer Center
 2014-03-19 PHASE1
NCT03465722 COMPLETED
GIST
Blueprint Medicines Corporation
 2018-03-26 PHASE3
NCT02386397 COMPLETED
Digestive Cancer
Institut du Cancer de Montpellier - Val d'Aurelle
 2014-09 PHASE1; PHASE2
NCT02736305 COMPLETED
Ovarian Neoplasms
National Cancer Centre, Singapore
 2016-02-03 PHASE2
NCT02048722 COMPLETED
Adult Angiosarcoma; Recurrent Adult Soft Tissue Sarcoma; Stage III Adult Soft Tissue Sarcoma; Stage IV Adult Soft Tissue Sarcoma
Northwestern University
 2014-06-13 PHASE2
NCT02406170 COMPLETED
Esophageal Neoplasms; Stomach Neoplasms; Neoplasm Metastasis
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
 2015-04 PHASE1; PHASE2
NCT02664077 TERMINATED
Stage III (IIIB or IIIC) Colon Cancer
NSABP Foundation Inc
 2016-06 PHASE3
NCT01896856 COMPLETED
Previously Treated Metastatic Colorectal Cancer
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
 2013-10-23 PHASE1; PHASE2
NCT02466009 COMPLETED
Metastatic Colorectal Cancer
University of Rochester
 2015-03 PHASE2
NCT01913639 COMPLETED
Esophageal Cancer; Gastric Cancer
Memorial Sloan Kettering Cancer Center
 2013-07 PHASE2
NCT03081494 COMPLETED
Metastatic Colorectal Cancer
Novartis Pharmaceuticals
 2017-06-09 PHASE1
NCT02085148 COMPLETED
Pediatric Oncology
Bayer
 2014-04-11 PHASE1
NCT03563157 TERMINATED
Colorectal Cancer Metastatic; mCRC
ImmunityBio, Inc.
 2018-09-28 PHASE1; PHASE2
NCT03898102 COMPLETED
Colorectal Cancer Metastatic
Chang Gung Memorial Hospital
 2016-03 PHASE2
NCT02162914 UNKNOWN
Cholangiocarcinoma
Erasme University Hospital
 2014-03-14 PHASE2
NCT02024607 COMPLETED
Advanced Gastrointestinal Cancer
Sumitomo Pharma America, Inc.
 2014-01 PHASE1; PHASE2
NCT02459119 COMPLETED
Urothelial Cancer (Urinary Bladder, Ureters, or Renal Pelvis Cancer)
University of Alabama at Birmingham
 2015-05 PHASE2
NCT02466802 COMPLETED
Solid Tumor
Virginia Commonwealth University
 2015-07-01 PHASE1
NCT02115542 COMPLETED
Cancer of the Bile Duct
H. Lee Moffitt Cancer Center and Research Institute
 2014-06-05 PHASE2
NCT03305913 COMPLETED
Pretreated Metastatic Colorectal Cancer
AIO-Studien-gGmbH
 2017-07-31 PHASE1
NCT01949194 UNKNOWN
Metastatic Colorectal Cancer
Gerald Batist
 2013-09 PHASE2
NCT02835924 COMPLETED
Metastatic Colorectal Cancer
Spanish Cooperative Group for the Treatment of Digestive Tumours (TTD)
 2016-07 PHASE2
NCT02587650 TERMINATED
ALK Fusion Protein Expression; BRAF wt Allele; Invasive Skin Melanoma; MET Fusion Gene Positive; NRAS wt Allele; NTRK1 Fusion Positive; NTRK2 Fusion Positive; NTRK3 Fusion Positive; RET Fusion Positive; ROS1 Fusion Positive; Stage III Cutaneous Melanoma; Stage IIIA Cutaneous Melanoma; Stage IIIB Cutaneous Melanoma; Stage IIIC Cutaneous Melanoma; Stage IV Cutaneous Melanoma
University of California, San Francisco
 2015-03-26 PHASE2
NCT01287598 COMPLETED
Neoplasms
Bayer
 2011-08-02 PHASE1
NCT02581059 TERMINATED
Colorectal Cancer; Palliative Medicine; Supportive Care
Wake Forest University Health Sciences
 2016-04 PHASE2
NCT03698253 COMPLETED
Colorectal Cancer
Kaohsiung Medical University Chung-Ho Memorial Hospital
 2013-10-01
NCT02606097 COMPLETED
Gastrointestinal Stromal Tumour (GIST)
Chang Gung Memorial Hospital
 2014-04 PHASE2
NCT02096354 COMPLETED
Colorectal Neoplasms
EpicentRx, Inc.
 2014-05 PHASE2
NCT02788279 COMPLETED
Colorectal Cancer
Hoffmann-La Roche
 2016-07-05 PHASE3
NCT02316340 COMPLETED
Colorectal Cancer
The University of Texas Health Science Center at San Antonio
 2015-02-11 PHASE2
NCT02651415 COMPLETED
Metastatic Colorectal Cancer
British Columbia Cancer Agency
 2016-08 PHASE2
NCT02800330 COMPLETED
Colorectal Neoplasms; Gastrointestinal Stromal Tumors
Erasmus Medical Center
 2016-05 PHASE4
NCT02053376 COMPLETED
Metastatic Biliary Tract Carcinoma
Nathan Bahary, MD
 2014-01 PHASE2
NCT02307500 COMPLETED
Pancreas Cancer; Ovarian Cancer; Melanoma; Sarcoma; Thymoma Type B3; Thymoma Type B2; Thymic Carcinoma
Istituto Clinico Humanitas
 2014-12 PHASE2
NCT02699073 COMPLETED
Metastatic Colorectal Cancer
GERCOR - Multidisciplinary Oncology Cooperative Group
 2016-02 PHASE2
NCT02402036 TERMINATED
Colon Cancer
Georgetown University
 2015-02 PHASE2
NCT02425683 TERMINATED
Colorectal Neoplasms; Adenocarcinoma of the Colon; Adenocarcinoma of the Rectum
US Oncology Research
 2015-03-26 PHASE2
NCT02383433 TERMINATED
Metastatic Pancreatic Adenocarcinoma
Case Comprehensive Cancer Center
 2016-06-14 PHASE2
NCT02368886 COMPLETED
Colon Adenocarcinoma; Rectal Adenocarcinoma; Stage III Colorectal Cancer AJCC v7; Stage IIIA Colorectal Cancer AJCC v7; Stage IIIB Colorectal Cancer AJCC v7; Stage IIIC Colorectal Cancer AJCC v7; Stage IV Colorectal Cancer AJCC v7; Stage IVA Colorectal Cancer AJCC v7; Stage IVB Colorectal Cancer AJCC v7
Academic and Community Cancer Research United
 2015-03-27 PHASE2
NCT02889328 COMPLETED
Gastrointestinal Stromal Tumors (GISTs)
Asan Medical Center
 2016-09 PHASE2
NCT02788006 COMPLETED
Colorectal Adenocarcinoma
Federation Francophone de Cancerologie Digestive
 2016-01 PHASE2
NCT02926222 COMPLETED
Glioblastoma Multiforme
Istituto Oncologico Veneto IRCCS
 2015-11 PHASE2
NCT02080260 COMPLETED
Pancreatic Cancer
Wake Forest University Health Sciences
 2014-06-06 PHASE2
NCT02195011 COMPLETED
Colorectal Neoplasms
SCRI Development Innovations, LLC
 2014-07 PHASE2
NCT02439723 WITHDRAWN
Metastatic Solid Malignancies; Locally Advanced Solid Malignancies
AHS Cancer Control Alberta
 2016-03 PHASE1
NCT02465502 COMPLETED
Colorectal Neoplasms
Bayer
 2015-07-21 PHASE2
NCT01973868 COMPLETED
Neoplasms
Bayer
 2013-11-21 PHASE1
NCT02164240 COMPLETED
Gastrointestinal Stromal Tumor
Dana-Farber Cancer Institute
 2014-07 PHASE1
NCT01298570 COMPLETED
Colorectal Cancer Metastatic
UNC Lineberger Comprehensive Cancer Center
 2011-04-07 PHASE2
NCT02287727 WITHDRAWN
Rectal Adenocarcinoma; Stage IIA Rectal Cancer; Stage IIB Rectal Cancer; Stage IIC Rectal Cancer; Stage IIIA Rectal Cancer; Stage IIIB Rectal Cancer
Roswell Park Cancer Institute
 2015-03 PHASE2
NCT02241720 TERMINATED
Upper GI Cancer
University of Utah
 2014-05 PHASE2
NCT01939223 TERMINATED
Colorectal Neoplasms
Bayer
 2013-12-02 PHASE3
NCT02175095 COMPLETED
Colorectal Cancer
Asan Medical Center
 2014-07-18
NCT02278783 TERMINATED
Ovarian Cancer; Primary Peritoneal Cancer; Fallopian Tube Cancer
University of Utah
 2015-03 PHASE2
NCT02234180 TERMINATED
Adenocarcinoma of the Gastroesophageal Junction; Stage IIB Esophageal Adenocarcinoma; Stage IIIA Esophageal Adenocarcinoma; Stage IIIB Esophageal Adenocarcinoma; Stage IIIC Esophageal Adenocarcinoma
Academic and Community Cancer Research United
 2014-09 PHASE2
NCT01929616 COMPLETED
Advanced Chemorefractory Colorectal Adenocarcinoma
Jules Bordet Institute
 2013-08 PHASE2
NCT02199223 TERMINATED
KRAS and NRAS Wild-type Colorectal Cancer
University of Utah
 2014-06 PHASE1
NCT01786538 WITHDRAWN
Metastatic Colorectal Cancer
Asan Medical Center
 2013-06 PHASE3
NCT01875380 COMPLETED
Colorectal Neoplasms; Metastatic Disease
Spanish Cooperative Group for the Treatment of Digestive Tumours (TTD)
 2013-06 PHASE2
NCT01774344 COMPLETED
Carcinoma, Hepatocellular
Bayer
 2013-05-14 PHASE3
NCT02287025 TERMINATED
Physician Education
Bayer
 2014-11-11 PHASE4
NCT02119676 TERMINATED
CRC (Colorectal Cancer)
Incyte Corporation
 2014-03 PHASE2
NCT02116894 COMPLETED
Colorectal Cancer
Duke University
 2014-08 PHASE1
NCT02175654 TERMINATED
Colorectal Neoplasms; Metastatic Disease
Spanish Cooperative Group for the Treatment of Digestive Tumours (TTD)
 2014-06 PHASE2
NCT02398513 COMPLETED
Oncology
Bayer
 2015-04 PHASE1
NCT02168777 TERMINATED
Neoplasms
Bayer
 2014-06-23 PHASE1
NCT02288078 UNKNOWN
Rectal Cancer
Clinical Research Support Center Kyush
 2014-10 PHASE2
NCT01853046 COMPLETED
Neoplasms
Bayer
 2013-06 PHASE1
NCT01996969 COMPLETED
Metastatic Colorectal Cancer
Seoul National University Hospital
 2013-10
NCT02222207 TERMINATED
Macular Degeneration
Bayer
 2014-10 PHASE2
NCT02106845 COMPLETED
Neoplasms
Bayer
 2014-04-22 PHASE1
NCT01853319 COMPLETED
Colorectal Neoplasms
Bayer
 2013-07-24 PHASE3
NCT02001909 COMPLETED
Neoplasms
Bayer
 2013-12 PHASE1
NCT01117623 COMPLETED
Neoplasm
Bayer
 2007-02 PHASE1
NCT01584830 COMPLETED
Colorectal Neoplasms
Bayer
 2012-04 PHASE3
NCT01339104 COMPLETED
Neoplasms
Bayer
 2011-04 PHASE1
NCT01189903 UNKNOWN
Asian Colorectal Cancer Patients
National University Hospital, Singapore
 2011-01 PHASE2; PHASE3
NCT01096030 COMPLETED
Neoplasms
Bayer
 2010-07 PHASE1
NCT01068769 COMPLETED
Gastrointestinal Stromal Tumor
Suzanne George, MD
 2010-02 PHASE2
NCT01187615 TERMINATED
Small Cell Lung Carcinoma
Bayer
 2010-08 PHASE1
NCT00934882 COMPLETED
Colorectal Neoplasms
Bayer
 2009-08 PHASE1
NCT01289821 COMPLETED
Colorectal Neoplasms
Bayer
 2011-02 PHASE2
NCT01271712 COMPLETED
Gastrointestinal Stromal Tumors
Bayer
 2011-01-04 PHASE3
NCT01318265 COMPLETED
Pharmacokinetics
Bayer
 2011-03 PHASE1
NCT01103323 COMPLETED
Metastatic Colorectal Cancer
Bayer
 2010-04 PHASE3
NCT01322438 COMPLETED
Neoplasms
Bayer
 2011-03 PHASE1
NCT00960258 COMPLETED
Tumors
Bayer
 2009-07-01 PHASE1
NCT01002378 COMPLETED
Dietary Fats; Pharmacokinetics
Bayer
 2009-10 PHASE1
NCT00664326 COMPLETED
Carcinoma, Renal Cell
Bayer
 2008-04-30 PHASE2

(data from https://clinicaltrials.gov, updated on 2026-07-16)

Check the Regorafenib (BAY 73-4506) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Compliance for Clinical Use

Mechanism and Biochemical Profile

Regorafenib binds to and inhibits multiple receptor tyrosine kinases, including VEGFR1–3, KIT, PDGFRβ, RET, and Raf-1, thereby suppressing downstream intracellular signaling cascades required for vascular endothelial function and cell survival. This targeted inhibition disrupts tumor angiogenesis and impedes cancer cell proliferation, providing therapeutic efficacy in clinically evaluated indications such as metastatic colorectal cancer, gastrointestinal stromal tumors, and hepatocellular carcinoma.

Appendix RUO and cGMP Quality Standards

Quality Dimension RUO (Research Use Only) cGMP (Current Good Manufacturing Practice)
Clinical Applicability Prohibited in human clinical trials or medical diagnostics. Mandatory for human clinical trials (Phase I–III) and therapies.
Regulatory Status Non-regulated grade; exempt from drug manufacturing laws. Legally enforced by health authorities (e.g., FDA, EMA, NMPA).
Facility Environment Unclassified analytical or research laboratories. Validated Cleanrooms (ISO Class 5–8) with continuous monitoring.
Quality Control Basic purity and activity testing. Rigorous safety release testing (Sterility, Endotoxin, Mycoplasma).
Process Validation Basic equipment calibration; no process validation required. Full qualification (IQ/OQ/PQ) and complete batch records.
Quality Assurance Vendor self-declared without required formal QMS. Mandatory QA/QC unit, Change Control, CAPA, and vendor audits.
Regulatory Impact High risk of IND rejection if used as a critical raw material. Required for IND/NDA filings, supported by Drug Master Files (DMF).

Footnotes

Regulatory Note: Governed by FDA (21 CFR Parts 210/211/312), EMA (EudraLex Vol 4), ICH Guidelines (E6/Q7/Q9/Q10), and compendial standards (USP <71>/<85>/<1043>).

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Note: Technical data last updated: Sep 1, 2026.