CAS No. 755037-03-7
| IUPAC Name | 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]-3-fluorophenoxy]-N-methylpyridine-2-carboxamide | |
|---|---|---|
| CAS Number | 755037-03-7 | |
| Molecular Formula |
C21H15ClF4N4O3 |
|
| Molecular Weight (MW) | 482.82 | |
| SMILES | CNC(=O)C1=NC=CC(=C1)OC2=CC(=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F)F | |
| InChIKey | FNHKPVJBJVTLMP-UHFFFAOYSA-N |
Regorafenib (BAY 73-4506) is a potent multikinase inhibitor targeting angiogenic, stromal, and oncogenic receptor tyrosine kinases, including VEGFR1, VEGFR2, VEGFR3, TIE2, PDGFR-β, FGFR1, KIT, RET, RAF-1, and BRAF. By suppressing these kinase cascades, regorafenib inhibits tumor angiogenesis and vascularization, disrupts downstream RAF/MEK/ERK signaling, blocks cell proliferation, induces autophagy, and exerts potent antitumor activity in preclinical xenograft models. [1]
|
Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
97 mg/mL
(200.9 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 3 mg/mL |
| Water | Insoluble |
| DMSO |
96 mg/mL
(198.83 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
97 mg/mL
(200.9 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
97 mg/mL
(200.9 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
97 mg/mL
(200.9 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 2 mg/mL |
| Water | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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- Regorafenib (BAY 73-4506) Mechanism of Action: VEGFR2 Inhibition in Endothelial Cells Research
- Regorafenib (BAY 73-4506) Clinical Trials
- Regorafenib (BAY 73-4506) Working Concentration | Cell Culture | Treatment
- Regorafenib (BAY 73-4506) Solubility in DMSO
- Regorafenib (BAY 73-4506) Stock Solution
- Regorafenib (BAY 73-4506) Storage
- Regorafenib (BAY 73-4506) Stability
- Regorafenib (BAY 73-4506) Combination Database
- Regorafenib (BAY 73-4506) Molecular Weight
- Regorafenib (BAY 73-4506) SMILES
- Regorafenib (BAY 73-4506) Chemical Structure (2D and 3D)
- Regorafenib (BAY 73-4506) IC50 for Cell-based and Cell-free Assays
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