Pifithrin-α (PFTα) Hhydrobromide: Mechanism of Action

Pifithrin-α (PFTα) Hhydrobromide MOA:Targeting p53/Apoptosis Pathway for Chemoprotection and Radioprotection

🎯 check Pifithrin-α (PFTα) Hhydrobromide product page

Pifithrin-α (PFTα) Hhydrobromide is a selective p53 inhibitor. It affects p53, AMPK/mTOR, and SIRT1-AMPK signaling pathways by blocking p53-dependent transcriptional activity and phosphorylation, effectively inhibiting apoptosis, ferroptosis, and senescence while promoting cell survival and autophagy.

Primary Applications and Mechanism of Action