CAS No. 63208-82-2

Batch: Purity:99.87
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Pifithrin-α (PFTα) Hhydrobromide Chemical Structure
Chemical Structure
Check the Pifithrin-α (PFTα) Hhydrobromide product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 2-(2-imino-4,5,6,7-tetrahydro-1,3-benzothiazol-3-yl)-1-(4-methylphenyl)ethanone;hydrobromide
CAS Number 63208-82-2
Molecular Formula

C16H18N2OS.HBr
Molecular Weight (MW) 367.3
SMILES CC1=CC=C(C=C1)C(=O)CN2C3=C(CCCC3)SC2=N.Br
InChIKey HAGVCKULCLQGRF-UHFFFAOYSA-N

Ordering Information

Biological Activity

Pifithrin-α Hydrobromide is a cell-permeable p53 inhibitor and aryl hydrocarbon receptor agonist. It selectively suppresses p53-dependent transactivation of p53-responsive genes, effectively blocking downstream p53-mediated signaling and transcription of apoptotic targets following DNA damage. Through this pathway inhibition, Pifithrin-α attenuates cellular apoptosis and protects normal cells and tissues against radiation- and chemotherapy-induced lethal toxicity. [1]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 73 mg/mL (198.74 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.