PF-06821497: Selectivity & Specificity
PF-06821497 is a potent inhibitor of CYP 1A2 (>30 μM), CYP 2C8 (>30 μM), CYP 2C9 (>30 μM), CYP 2C19 (>30 μM), CYP 2D6 (>30 μM), CYP 3A4 (>30 μM). PF-06821497 exhibits the greatest inhibitory potency toward CYP 1A2 (IC50 = >30000 nM).