Target Selectivity of PF-06821497
| Key Target | IC50 | Description | Reference |
|---|---|---|---|
| CYP 1A2 | 30 μM | in vitro assay against these enzymes | PM29211475 |
| CYP 2C8 | 30 μM | in vitro assay against these enzymes | PM29211475 |
| CYP 2C9 | 30 μM | in vitro assay against these enzymes | PM29211475 |
| CYP 2C19 | 30 μM | in vitro assay against these enzymes | PM29211475 |
| CYP 2D6 | 30 μM | in vitro assay against these enzymes | PM29211475 |
| CYP 3A4 | 30 μM | in vitro assay against these enzymes | PM29211475 |
Check the
PF-06821497
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Cell-free Assays (IC50/Ki) for PF-06821497
| Key Target | IC50 (Cell-free) | Description | Reference |
|---|---|---|---|
| CYP 1A2 | >30 μM | in vitro assay against these enzymes | PM29211475 |
| CYP 2C8 | >30 μM | in vitro assay against these enzymes | PM29211475 |
| CYP 2C9 | >30 μM | in vitro assay against these enzymes | PM29211475 |
| CYP 2C19 | >30 μM | in vitro assay against these enzymes | PM29211475 |
| CYP 2D6 | >30 μM | in vitro assay against these enzymes | PM29211475 |
| CYP 3A4 | >30 μM | in vitro assay against these enzymes | PM29211475 |
Cell-based Assay (IC50) for PF-06821497
| Cell Type | IC50 (Cell-based) | Description | Reference |
|---|---|---|---|
| hERG ion channel | >100 μM | in vitro assessment | PM29211475 |
Jump to
- PF-06821497 Mechanism of Action: EZH2 Inhibition in Prostate Cancer Cell Research
- PF-06821497 Clinical Trials
- PF-06821497 Working Concentration | Cell Culture | Treatment
- PF-06821497 Solubility in DMSO
- PF-06821497 Stock Solution
- PF-06821497 Storage
- PF-06821497 Stability
- PF-06821497 Combination Database
- PF-06821497 Molecular Weight
- PF-06821497 SMILES
- PF-06821497 CAS Number
- PF-06821497 Chemical Structure (2D and 3D)
- PF-06821497 IC50 for Cell-based and Cell-free Assays
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- PF-06821497 SDS｜MSDS