SMILES:
CC1=CC(=C(C(=O)N1)CN2CCC3=C(C=C(C(=C3C2=O)Cl)C(C4COC4)OC)Cl)OC
Chemical Structure
Check the
PF-06821497
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 5,8-dichloro-2-[(4-methoxy-6-methyl-2-oxo-1H-pyridin-3-yl)methyl]-7-[(R)-methoxy(oxetan-3-yl)methyl]-3,4-dihydroisoquinolin-1-one | |
|---|---|---|
| CAS Number | 1844849-10-0 | |
| Molecular Formula |
C22H24Cl2N2O5 |
|
| Molecular Weight (MW) | 467.34 | |
| SMILES | CC1=CC(=C(C(=O)N1)CN2CCC3=C(C=C(C(=C3C2=O)Cl)C(C4COC4)OC)Cl)OC | |
| InChIKey | RXCVUHMIWHRLDF-HXUWFJFHSA-N |
|
Concentration
Volume
Mass
|
1 mg | 5 mg | 10 mg |
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
93 mg/mL
(198.99 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| DMSO |
93 mg/mL
(198.99 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 23 mg/mL |
| Water | Insoluble |
| DMSO |
15 mg/mL
(32.09 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 4 mg/mL |
| Ethanol | 2 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- PF-06821497 Mechanism of Action: EZH2 Inhibition in Prostate Cancer Cell Research
- PF-06821497 Clinical Trials
- PF-06821497: Selectivity & Specificity
- PF-06821497 Working Concentration | Cell Culture | Treatment
- PF-06821497 Solubility in DMSO
- PF-06821497 Stock Solution
- PF-06821497 Storage
- PF-06821497 Stability
- PF-06821497 Combination Database
- PF-06821497 Molecular Weight
- PF-06821497 CAS Number
- PF-06821497 Chemical Structure (2D and 3D)
- PF-06821497 IC50 for Cell-based and Cell-free Assays
- PF-06821497 Sigma (XPIH9C170B10)? Try a better option.
- PF-06821497 Abmole (M13421)? Try a better option.
- PF-06821497 Cayman (42500)? Try a better option.
- PF-06821497 Axonmedchem (Axon 3695)? Try a better option.
- PF-06821497 AdooQ (A21388)? Try a better option.
- PF-06821497 SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.