Pexidartinib (PLX3397): Selectivity & Specificity
Pexidartinib (PLX3397) is a potent inhibitor of FLT3-ITD (9 nM), KIT (12 nM), CSF1R (17 nM), FLT3-ITK (< 1000 nM), FLT3, FOXP3, CD8A, CD4, IL34, CSF1, IL4, IL13, TGFB1, IL10, CXCR4, CXCL12, TRAF6, FOSL1, FOS, NFATC1. Pexidartinib (PLX3397) exhibits the greatest inhibitory potency toward FLT3-ITD (IC50 = 9 nM).