CAS No. 1029044-16-3

Batch: Purity:99.94
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Pexidartinib (PLX3397) Chemical Structure
Chemical Structure
Check the Pexidartinib (PLX3397) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 5-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-N-[[6-(trifluoromethyl)-3-pyridinyl]methyl]pyridin-2-amine
CAS Number 1029044-16-3
Molecular Formula

C20H15ClF3N5
Molecular Weight (MW) 417.81
SMILES C1=CC(=NC=C1CC2=CNC3=C2C=C(C=N3)Cl)NCC4=CN=C(C=C4)C(F)(F)F
InChIKey JGWRKYUXBBNENE-UHFFFAOYSA-N

Ordering Information

Biological Activity

Pexidartinib (PLX3397) is an oral multi-targeted receptor tyrosine kinase inhibitor that potently targets colony-stimulating factor 1 receptor (CSF-1R), c-Kit, and FLT3. By blocking CSF-1R signaling, pexidartinib impairs macrophage recruitment and alters tumor-associated macrophage polarization within the tumor microenvironment. This inhibition disrupts cell survival pathways, leading to the induction of apoptosis and necrosis while suppressing tumor growth and progression. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 84 mg/mL (201.04 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.