MLN4924 (Pevonedistat) is a potent NEDD8-activating enzyme (NAE) inhibitor. It affects PI3K/AKT, NF-κB, and RhoA/ROCK signaling pathways by blocking Cullin-RING ligase neddylation and stabilizing substrates like p21 and p27, thereby inhibiting cancer cell proliferation, migration, and inducing apoptosis.
MLN4924 (Pevonedistat) IC50 for Cell-based and Cell-free Assays
Comprehensive IC50 Values for MLN4924 (Pevonedistat) Across Cell-free Enzyme Inhibitory Profiles and Cell-based Functional Assays.