CAS No. 905579-51-3
Batch:
Purity:99.99
Chemical Structure
Check the
MLN4924 (Pevonedistat)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | [(1S,2S,4R)-4-[4-[[(1S)-2,3-dihydro-1H-inden-1-yl]amino]pyrrolo[2,3-d]pyrimidin-7-yl]-2-hydroxycyclopentyl]methyl sulfamate | |
|---|---|---|
| CAS Number | 905579-51-3 | |
| Molecular Formula |
C21H25N5O4S |
|
| Molecular Weight (MW) | 443.52 | |
| SMILES | C1CC2=CC=CC=C2C1NC3=C4C=CN(C4=NC=N3)C5CC(C(C5)O)COS(=O)(=O)N | |
| InChIKey | MPUQHZXIXSTTDU-QXGSTGNESA-N |
MLN4924 (Pevonedistat) is a small molecule inhibitor of Nedd8 activating enzyme (NAE) with an IC50 of. By inhibiting NAE, MLN4924 prevents neddylation of cullin-RING ligases, leading to the accumulation of ubiquitin ligase substrates. This disruption impairs cell cycle progression, induces DNA re-replication, and triggers apoptosis in various cancer cell lines. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
89 mg/mL
(200.66 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 22 mg/mL |
| Water | Insoluble |
| DMSO |
89 mg/mL
(200.66 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 89 mg/mL |
| Water | Insoluble |
| DMSO |
89 mg/mL
(200.66 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 89 mg/mL |
| Water | Insoluble |
| DMSO |
89 mg/mL
(200.66 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 45 mg/mL |
| Water | Insoluble |
| DMSO |
89 mg/mL
(200.66 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 22 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- MLN4924 (Pevonedistat) Mechanism of Action: NAE Inhibition in Hematopoietic Cancer Cell Research
- MLN4924 (Pevonedistat) Clinical Trials
- MLN4924 (Pevonedistat): Selectivity & Specificity
- MLN4924 (Pevonedistat) Working Concentration | Cell Culture | Treatment
- MLN4924 (Pevonedistat) Solubility in DMSO
- MLN4924 (Pevonedistat) Stock Solution
- MLN4924 (Pevonedistat) Storage
- MLN4924 (Pevonedistat) Stability
- MLN4924 (Pevonedistat) Combination Database
- MLN4924 (Pevonedistat) Molecular Weight
- MLN4924 (Pevonedistat) SMILES
- MLN4924 (Pevonedistat) Chemical Structure (2D and 3D)
- MLN4924 (Pevonedistat) IC50 for Cell-based and Cell-free Assays
- MLN4924 (Pevonedistat) Sigma (5.05477)? Try a better option.
- MLN4924 (Pevonedistat) MedChemExpress (HY-70062)? Try a better option.
- MLN4924 (Pevonedistat) Cell Signaling Technology (85923)? Try a better option.
- MLN4924 (Pevonedistat) STEMCELL (74184)? Try a better option.
- MLN4924 (Pevonedistat) Cayman (15217)? Try a better option.
- MLN4924 (Pevonedistat) SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.