Palbociclib (PD-0332991): Selectivity & Specificity
Palbociclib (PD-0332991) is a potent inhibitor of CDK4 (9 nM), CDK6 (9.5 nM), Cyclin D1–CDK4 complex (11 nM), Cyclin D1/2/3–CDK6 complex (16 nM), CDK4/cyclinD1 complex (10 nM), CDK4/cyclinD3 complex (9 nM), CDK6/cyclinD2 complex (15 nM), PI3K, PI3Kd, COX-2, FOXM1, RB1, RBL1, RBL2, E2F, CCND1. Palbociclib (PD-0332991) exhibits the greatest inhibitory potency toward CDK4/cyclinD3 complex (IC50 = 9 nM).