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Palbociclib is a potent CDK4/6 inhibitor. It affects CDK-Rb-E2F signaling by blocking Rb phosphorylation, inducing G1 arrest.
Palbociclib (PD-0332991): Mechanism of Action
Palbociclib (PD-0332991) MOA：Targeting CDK4/6 / Rb Pathway for Clinical Trials and Real-World Efficacy in Metastatic Breast Cancer