|
ZR75.1 parental cells
|
1.7 µM
|
Previous compound experiments (cell viability/growth assay)
|
Download PDF
|
|
L6565 monolayer cultured cells
|
1.39 μM
|
Presto Blue Cell Viability reagent, fluorescence measured at 550/600 nm
|
Download PDF
|
|
L6565 MCTS cultures
|
1.44 μM
|
Presto Blue Cell Viability reagent, fluorescence measured at 550/600 nm
|
Download PDF
|
|
L6565 MCTS cultures
|
2.99 μM
|
Presto Blue Cell Viability reagent, fluorescence measured at 550/600 nm
|
Download PDF
|
|
L6565 microsarc cultures
|
35.97 μM
|
Presto Blue Cell Viability reagent, fluorescence measured at 550/600 nm
|
Download PDF
|
|
L6565 microsarc cultures
|
0.049 μM
|
Presto Blue Cell Viability reagent, fluorescence measured at 550/600 nm
|
Download PDF
|
|
73 R cells
|
0.1 µM
|
WST-1 colorimetric assay, analyzed using log inhibitor vs response, variable slope (four parameters), least squares fit
|
PMC13009525
|
|
73 R cultures (3D-Matrigel)
|
0.1 µM
|
WST-1 colorimetric assay, analyzed using log inhibitor vs response, variable slope (four parameters), least squares fit
|
PMC13009525
|
|
WT cultures (3D-Matrigel)
|
0.1 µM
|
WST-1 colorimetric assay, analyzed using log inhibitor vs response, variable slope (four parameters), least squares fit
|
PMC13009525
|
|
SH-SY5Y cells
|
0.86 µM
|
MTT colorimetric assay
|
PMC12322058
|
|
HCC-1937
|
14.5 µM
|
Cell viability assay (PrestoBlue HS Cell Viability Reagent)
|
Download PDF
|
|
MDA-MB-231
|
4.1 µM
|
Cell viability assay (PrestoBlue HS Cell Viability Reagent)
|
Download PDF
|
|
MDA-MB-453
|
27 µM
|
Cell viability assay (PrestoBlue HS Cell Viability Reagent)
|
Download PDF
|
|
HCC1806 scramble control cells
|
1.8 µM
|
Dose-response analysis
|
PMC12828054
|
|
HCC1806 shCDK2 cells
|
0.15 µM
|
Dose-response analysis
|
PMC12828054
|
|
HCC1806 shCCNE1 cells
|
0.11 µM
|
Dose-response analysis
|
PMC12828054
|
|
MCF7 PR1.2 parental cells
|
1.5 µM
|
Dose-response assay
|
PMC12828054
|
|
MCF7 PR1.2 p21 KO pools
|
3 µM
|
Dose-response assay
|
PMC12828054
|
|
MCF7 PR1.2 p21 KO CL1
|
4 µM
|
Dose-response assay
|
PMC12828054
|
|
MCF7 PR1.2 p21 KO CL3
|
3.5 µM
|
Dose-response assay
|
PMC12828054
|
|
HCT116
|
0.75 µM
|
Hoechst 33342 staining
|
Download PDF
|
|
MCF7 parental
|
0.75 μM
|
crystal violet assay
|
PMC12297654
|
|
T47D parental
|
0.75 μM
|
crystal violet assay
|
PMC12297654
|
|
MCF7 parental shSCR
|
0.75 μM
|
crystal violet assay
|
PMC12297654
|
|
T47D parental shSCR
|
0.75 μM
|
crystal violet assay
|
PMC12297654
|
|
BT-474
|
500 nM
|
Cell viability MTT assay (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) and tetrazolium reduction assay
|
Download PDF
|
|
BT-474
|
500 nM
|
Cell viability MTT assay (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) and tetrazolium reduction assay
|
Download PDF
|
|
MCF7
|
500 nM
|
Cell viability MTT assay (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) and tetrazolium reduction assay
|
Download PDF
|
|
MCF7
|
500 nM
|
Cell viability MTT assay (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) and tetrazolium reduction assay
|
Download PDF
|
|
HS-578T
|
500 nM
|
Cell viability MTT assay (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) and tetrazolium reduction assay
|
Download PDF
|
|
HS-578T
|
500 nM
|
Cell viability MTT assay (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) and tetrazolium reduction assay
|
Download PDF
|
|
JN-DSRCT1
|
1.09 µM
|
Cell Proliferation Assays using CellTiter-Glo® luminescent cell viability assay
|
PMC11358472
|
|
HeLa cells
|
105.6 μmol/L
|
MTT assay
|
PMC11392100
|
|
HeLa cells
|
6.482 μmol/L
|
MTT assay
|
PMC11392100
|
|
HeLa cells
|
6.074 μmol/L
|
MTT assay
|
PMC11392100
|
|
MCF7
|
750 nM
|
thiazolyl blue tetrazolium bromide (MTT) assay
|
Download PDF
|
|
T47D
|
250 nM
|
thiazolyl blue tetrazolium bromide (MTT) assay
|
Download PDF
|
|
LN-18
|
1.94 µM
|
Sulforhodamine B (SRB) colorimetric assay, non-linear least squares curve fitting (four parameter analysis, log (inhibitor) vs. response, variable slope) using Gen5 software.
|
PMC11092418
|
|
LN-18
|
2.07 µM
|
Sulforhodamine B (SRB) colorimetric assay, non-linear least squares curve fitting (four parameter analysis, log (inhibitor) vs. response, variable slope) using Gen5 software.
|
PMC11092418
|
|
A172
|
1.16 µM
|
Sulforhodamine B (SRB) colorimetric assay, non-linear least squares curve fitting (four parameter analysis, log (inhibitor) vs. response, variable slope) using Gen5 software.
|
PMC11092418
|
|
A172
|
4.69 µM
|
Sulforhodamine B (SRB) colorimetric assay, non-linear least squares curve fitting (four parameter analysis, log (inhibitor) vs. response, variable slope) using Gen5 software.
|
PMC11092418
|
|
U118MG
|
0.45 µM
|
Sulforhodamine B (SRB) colorimetric assay, non-linear least squares curve fitting (four parameter analysis, log (inhibitor) vs. response, variable slope) using Gen5 software.
|
PMC11092418
|
|
U118MG
|
2.46 µM
|
Sulforhodamine B (SRB) colorimetric assay, non-linear least squares curve fitting (four parameter analysis, log (inhibitor) vs. response, variable slope) using Gen5 software.
|
PMC11092418
|
|
T-98G
|
0.56 µM
|
Sulforhodamine B (SRB) colorimetric assay, non-linear least squares curve fitting (four parameter analysis, log (inhibitor) vs. response, variable slope) using Gen5 software.
|
PMC11092418
|
|
T-98G
|
4.78 µM
|
Sulforhodamine B (SRB) colorimetric assay, non-linear least squares curve fitting (four parameter analysis, log (inhibitor) vs. response, variable slope) using Gen5 software.
|
PMC11092418
|
|
MCL cell lines
|
13.6 nM
|
Anti-proliferative effect assay
|
Download PDF
|
|
MOLM-13
|
0.2 µM
|
Cell viability assay, MTS reagent, nonlinear best-fit regression analysis using Prism 8 software.
|
Download PDF
|
|
MOLM-14
|
1.9 µM
|
Cell viability assay, MTS reagent, nonlinear best-fit regression analysis using Prism 8 software.
|
Download PDF
|
|
MV4-11
|
1.1 µM
|
Cell viability assay, MTS reagent, nonlinear best-fit regression analysis using Prism 8 software.
|
Download PDF
|
|
Kasumi-1
|
2.4 µM
|
Cell viability assay, MTS reagent, nonlinear best-fit regression analysis using Prism 8 software.
|
Download PDF
|
|
LS411N
|
0.8 µM
|
acid phosphatase assay
|
Download PDF
|
|
SNUC4
|
1.7 µM
|
acid phosphatase assay
|
Download PDF
|
|
KOBR-011 (S6K1amp PDO)
|
15 μM
|
CellTiter-Glo® assay
|
Download PDF
|
|
KOBR-029 (S6K1amp PDO)
|
15 μM
|
CellTiter-Glo® assay
|
Download PDF
|
|
KOBR-716 (S6K1amp PDO)
|
11 μM
|
CellTiter-Glo® assay
|
Download PDF
|
|
KOBR-711 (S6K1wt PDO)
|
7 μM
|
CellTiter-Glo® assay
|
Download PDF
|
|
KOBR-715 (S6K1wt PDO)
|
4 μM
|
CellTiter-Glo® assay
|
Download PDF
|
|
KOBR-722 (S6K1wt PDO)
|
3 μM
|
CellTiter-Glo® assay
|
Download PDF
|
|
13 HPVneg HNSCC cell lines and MCF-7
|
0.908 to 47.88 μM (range for HNSCC cell lines)
|
Cell Counting Kit-8 assay
|
Download PDF
|
|
K562
|
100 nM
|
Cell viability assessed by trypan-blue exclusion, and IC50s calculated using GraphPad Prism software.
|
Download PDF
|
|
MV4;11
|
100 nM
|
Cell viability assessed by trypan-blue exclusion, and IC50s calculated using GraphPad Prism software.
|
Download PDF
|
|
U937
|
100 nM
|
Cell viability assessed by trypan-blue exclusion, and IC50s calculated using GraphPad Prism software.
|
Download PDF
|
|
THP-1
|
100 nM
|
Cell viability assessed by trypan-blue exclusion, and IC50s calculated using GraphPad Prism software.
|
Download PDF
|
|
K562 (E2F1 reporter)
|
100 nM
|
Cell viability assay (implied trypan-blue exclusion).
|
Download PDF
|
|
EFM19
|
78 nmol/L
|
in vitro proliferation assays; cell counting via brightfield image segmentation on a Synentec Cellavista® imaging system
|
Download PDF
|
|
Caki-1
|
0.4662 µM
|
Cell Counting Kit-8 (CCK-8) assay
|
Download PDF
|
|
OSRC-2
|
0.5548 µM
|
Cell Counting Kit-8 (CCK-8) assay
|
Download PDF
|
|
769-P
|
1.256 µM
|
Cell Counting Kit-8 (CCK-8) assay
|
Download PDF
|
|
786-O
|
7.718 µM
|
Cell Counting Kit-8 (CCK-8) assay
|
Download PDF
|
|
DAOY
|
24h: 20.57mM, 48h: 15.57mM, 72h: 14.42mM
|
WST-1 viability analysis, determined from log concentrations-effect curves in GraphPad Prism using non-linear regression analysis.
|
Download PDF
|
|
UW228-3
|
>20mM
|
WST-1 viability analysis, determined from log concentrations-effect curves in GraphPad Prism using non-linear regression analysis.
|
Download PDF
|
|
HK-1
|
3–35 µM
|
IC50 Calculator, [Vendor]
|
Download PDF
|
|
NPC-B13
|
3–35 µM
|
IC50 Calculator, [Vendor]
|
Download PDF
|
|
C666-1
|
3–35 µM
|
IC50 Calculator, [Vendor]
|
Download PDF
|
|
MCF7-P2-RE
|
8.0 µM
|
WST assay
|
Download PDF
|
|
CTC-ITB-01
|
0.21 µM
|
IncuCyte Zoom live cell imaging system; Three-parameter non-linear logistic regression
|
Download PDF
|
|
MCF-7
|
0.13 µM
|
IncuCyte Zoom live cell imaging system; Three-parameter non-linear logistic regression
|
Download PDF
|
|
C666–1
|
Day 1: 35.67 μM, Day 3: 22.36 μM, Day 5: 10.53 μM
|
resazurin assay
|
Download PDF
|
|
C17
|
Day 1: 36.12 μM, Day 3: 20.23 μM, Day 5: 12.75 μM
|
resazurin assay
|
Download PDF
|
|
NPC43
|
Day 1: 50.07 μM, Day 3: 24.63 μM, Day 5: 17.15 μM
|
resazurin assay
|
Download PDF
|
|
NPC43 parental
|
28.61 μM
|
resazurin cell viability assay
|
Download PDF
|
|
NPC43 subline #5 (cisplatin-resistant)
|
19.74 μM
|
resazurin cell viability assay
|
Download PDF
|
|
NPC43 subline #5 N (cisplatin-resistant)
|
16.83 μM
|
resazurin cell viability assay
|
Download PDF
|
|
IB115
|
1.3 μM
|
MTT assay (for cell growth), Western blot (for Rb phosphorylation)
|
Download PDF
|
|
IB111
|
4 μM
|
MTT assay (for cell growth), Western blot (for Rb phosphorylation)
|
Download PDF
|
|
IB114
|
1.2 μM
|
Western blot (for Rb phosphorylation)
|
Download PDF
|
|
IB136
|
1.3 μM
|
Western blot (for Rb phosphorylation)
|
Download PDF
|
|
IB128
|
1 μM
|
Western blot (for Rb phosphorylation)
|
Download PDF
|
|
CS-1
|
0.3965 μM
|
MTT assay
|
Download PDF
|
|
SW1353
|
0.4308 μM
|
MTT assay
|
Download PDF
|
|
HEC1A
|
0.65 μM
|
Proliferation assay, cell counting using a hemocytometer with trypan blue stain.
|
Download PDF
|
|
HEC108
|
0.58 μM
|
Proliferation assay, cell counting using a hemocytometer with trypan blue stain.
|
Download PDF
|
|
U87
|
11 μM
|
cell viability assay (CCK-8)
|
Download PDF
|
|
N33
|
12 μM
|
cell viability assay (CCK-8)
|
Download PDF
|
|
EA.hy926
|
10.279 µmol/L
|
MTT assay
|
Download PDF
|
|
EA.hy926
|
4.241 µmol/L
|
MTT assay
|
Download PDF
|
|
EA.hy926
|
2.574 µmol/L
|
MTT assay
|
Download PDF
|
|
papillary carcinoma organoids
|
2.21 μmol
|
CellTiter-Glo3D reagent luminescence assay, data analyzed using GraphPad Prism 6, and IC50 values determined manually.
|
Download PDF
|
|
Ma-Mel-123 cells
|
10.05 µM
|
Cellular viability was assessed using ([Vendor]). IC50 calculations were performed in GraphPad Prism®.
|
Download PDF
|
|
Ma-Mel-93 cells
|
10.19 µM
|
Cellular viability was assessed using ([Vendor]). IC50 calculations were performed in GraphPad Prism®.
|
Download PDF
|
|
Fibroblasts
|
17.57 µM
|
Cellular viability was assessed using ([Vendor]). IC50 calculations were performed in GraphPad Prism®.
|
Download PDF
|
|
CNE-1
|
2.05 μM
|
CCK8 assay
|
PMC6924590
|
|
CNE-2
|
0.86 μM
|
CCK8 assay
|
PMC6924590
|
|
H1975S
|
12.94 μmol/mL
|
Cell Counting Kit-8 (CCK8) assay
|
Download PDF
|
|
H1975OR
|
4.776 μmol/mL
|
Cell Counting Kit-8 (CCK8) assay
|
Download PDF
|
|
healthy HPASMCs
|
112 nM
|
BrdU incorporation (relative absorbance [A370nm –A492nm])
|
Download PDF
|
|
IPAH-HPASMCs
|
29.51 nM
|
BrdU incorporation (relative absorbance [A370nm –A492nm])
|
Download PDF
|
|
Primary CML cells
|
5 nM
|
3H-thymidine uptake
|
PMC6921367
|
|
Primary CML cells
|
11 nM
|
3H-thymidine uptake
|
PMC6921367
|
|
Primary CML cells
|
2 nM
|
3H-thymidine uptake
|
PMC6921367
|
|
Primary CML cells
|
338 nM
|
3H-thymidine uptake
|
PMC6921367
|
|
Primary CML cells
|
5 nM
|
3H-thymidine uptake
|
PMC6921367
|
|
Primary CML cells
|
16 nM
|
3H-thymidine uptake
|
PMC6921367
|
|
Primary CML cells
|
19 nM
|
3H-thymidine uptake
|
PMC6921367
|
|
Primary CML cells
|
1 nM
|
3H-thymidine uptake
|
PMC6921367
|
|
Primary CML cells
|
48 nM
|
3H-thymidine uptake
|
PMC6921367
|
|
TMZ-R cells
|
1.0 μM
|
Cell viability assay (MTT assay)
|
Download PDF
|
|
TMZ-S cells
|
0.5 μM
|
Cell viability assay (MTT assay)
|
Download PDF
|
|
ORL-215
|
0.2 μM
|
crystal violet cytostatic assay
|
PMC6713638
|
|
ORL-136
|
0.2 μM
|
crystal violet cytostatic assay
|
PMC6713638
|
|
ORL-156
|
0.2 μM
|
crystal violet cytostatic assay
|
PMC6713638
|
|
ORL-207
|
0.2 μM
|
crystal violet cytostatic assay
|
PMC6713638
|
|
ORL-153
|
0.2 μM
|
crystal violet cytostatic assay
|
PMC6713638
|
|
ORL-195
|
0.2 μM
|
crystal violet cytostatic assay
|
PMC6713638
|
|
ORL-204
|
0.2 μM
|
crystal violet cytostatic assay
|
PMC6713638
|
|
ORL-174
|
0.2 μM
|
crystal violet cytostatic assay
|
PMC6713638
|
|
ORL-48
|
0.2 μM
|
crystal violet cytostatic assay
|
PMC6713638
|
|
ORL-247
|
0.2 μM
|
crystal violet cytostatic assay
|
PMC6713638
|
|
ORL-214
|
0.2 μM
|
crystal violet cytostatic assay
|
PMC6713638
|
|
CAL27
|
0.2 μM
|
crystal violet cytostatic assay
|
PMC6713638
|
|
ORL-196
|
0.2 μM
|
crystal violet cytostatic assay
|
PMC6713638
|
|
ORL-188
|
1.2 μM
|
crystal violet cytostatic assay
|
PMC6713638
|
|
ORL-115
|
1.5 μM
|
crystal violet cytostatic assay
|
PMC6713638
|
|
ORL-150
|
1.8 μM
|
crystal violet cytostatic assay
|
PMC6713638
|
|
MCF-7
|
0.05 μM
|
crystal violet cytostatic assay
|
PMC6713638
|
|
Yamato-SS
|
0.83 µM
|
MTT assay
|
Download PDF
|
|
Aska-SS
|
0.98 µM
|
MTT assay
|
Download PDF
|
|
SYO-1
|
0.12 µM
|
MTT assay
|
Download PDF
|
|
CME-1
|
8.0 µM
|
MTT assay
|
Download PDF
|
|
A549
|
< 100 nM
|
3D-spheroid formation assay
|
Download PDF
|
|
SKOV3
|
< 100 nM
|
3D-spheroid formation assay
|
Download PDF
|
|
MCF7
|
< 100 nM
|
3D-spheroid formation assay
|
Download PDF
|
|
MDAH
|
20 µM
|
CellTiter 96 AQueous cell proliferation assay kit
|
Download PDF
|
|
KURAMOCHI
|
40 µM
|
CellTiter 96 AQueous cell proliferation assay kit
|
Download PDF
|
|
OVSAHO
|
40 µM
|
CellTiter 96 AQueous cell proliferation assay kit
|
Download PDF
|
|
SKOV3ip
|
30 µM
|
CellTiter 96 AQueous cell proliferation assay kit
|
Download PDF
|
|
OVCAR8
|
20 µM
|
CellTiter 96 AQueous cell proliferation assay kit
|
Download PDF
|
|
IMR-32
|
261 nM
|
Cell proliferation was measured with a programmed signal detection every 1 h and the signal was normalized to the transfection or palbociclib treatment time point where the cell index at every time point was divided by the cell index at the time of transf
|
Download PDF
|
|
SH-SY5Y
|
676 nM
|
Cell proliferation was measured with a programmed signal detection every 1 h and the signal was normalized to the transfection or palbociclib treatment time point where the cell index at every time point was divided by the cell index at the time of transf
|
Download PDF
|
|
NGP
|
2077 nM
|
Cell proliferation was measured with a programmed signal detection every 1 h and the signal was normalized to the transfection or palbociclib treatment time point where the cell index at every time point was divided by the cell index at the time of transf
|
Download PDF
|
|
SH-EP
|
2211 nM
|
Cell proliferation was measured with a programmed signal detection every 1 h and the signal was normalized to the transfection or palbociclib treatment time point where the cell index at every time point was divided by the cell index at the time of transf
|
Download PDF
|
|
SK-N-SH
|
7,482 × 10^5 nM
|
Cell proliferation was measured with a programmed signal detection every 1 h and the signal was normalized to the transfection or palbociclib treatment time point where the cell index at every time point was divided by the cell index at the time of transf
|
Download PDF
|
|
NLF
|
1,109 × 10^4 nM
|
Cell proliferation was measured with a programmed signal detection every 1 h and the signal was normalized to the transfection or palbociclib treatment time point where the cell index at every time point was divided by the cell index at the time of transf
|
Download PDF
|
|
CLB-GA
|
2,579 × 10^5 nM
|
Cell proliferation was measured with a programmed signal detection every 1 h and the signal was normalized to the transfection or palbociclib treatment time point where the cell index at every time point was divided by the cell index at the time of transf
|
Download PDF
|
|
SK-N-BE(2c)
|
1,285 × 10^4 nM
|
Cell proliferation was measured with a programmed signal detection every 1 h and the signal was normalized to the transfection or palbociclib treatment time point where the cell index at every time point was divided by the cell index at the time of transf
|
Download PDF
|
|
Sk-Mel-2
|
2.14 µM
|
colorimetric acid phosphatase assay; CalcuSyn software
|
Download PDF
|
|
Malme-3M
|
0.14 µM
|
colorimetric acid phosphatase assay; CalcuSyn software
|
Download PDF
|
|
Sk-Mel-5
|
0.50 µM
|
colorimetric acid phosphatase assay; CalcuSyn software
|
Download PDF
|
|
Sk-Mel-28
|
1.83 µM
|
colorimetric acid phosphatase assay; CalcuSyn software
|
Download PDF
|
|
M14
|
2.29 µM
|
colorimetric acid phosphatase assay; CalcuSyn software
|
Download PDF
|
|
Lox-IMVI
|
0.30 µM
|
colorimetric acid phosphatase assay; CalcuSyn software
|
Download PDF
|
|
WM115
|
1.00 µM
|
colorimetric acid phosphatase assay; CalcuSyn software
|
Download PDF
|
|
WM266-4
|
0.13 µM
|
colorimetric acid phosphatase assay; CalcuSyn software
|
Download PDF
|
|
MCF7
|
0.5 µM
|
Dose-response studies, crystal violet staining, absorbance measurement at 570 nm
|
Download PDF
|
|
T47D
|
0.5 µM
|
Dose-response studies, crystal violet staining, absorbance measurement at 570 nm
|
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|
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ZR75-1
|
0.5 µM
|
Dose-response studies, crystal violet staining, absorbance measurement at 570 nm
|
Download PDF
|
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MCF10A
|
10 µM
|
Dose-response studies, crystal violet staining, absorbance measurement at 570 nm
|
Download PDF
|
