Palbociclib is a potent CDK4/6 inhibitor. It affects CDK-Rb-E2F signaling by blocking Rb phosphorylation, inducing G1 arrest.
Palbociclib (PD-0332991) IC50 for Cell-based and Cell-free Assays
Comprehensive IC50 Values for Palbociclib (PD-0332991) Across Cell-free Enzyme Inhibitory Profiles and Cell-based Functional Assays.