Norepinephrine tartrate Clinical Trials

Size	Price	Qty
25mg	USD 147
100mg	USD 297

Clinical Trials

Numerous clinical trials evaluate the therapeutic applications of norepinephrine across critical care and surgical settings, focusing on conditions such as septic shock, spinal-induced hypotension, post-induction hypotension, acute kidney injury, and secondary peritonitis. Driven primarily by global academic medical centers and university hospitals, these studies span Early Phase 1 through Phase 4 across various recruitment statuses, including recruiting, active, and completed trials. This broad pipeline underscores norepinephrine's essential role in cardiovascular management and hemodynamic support.

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT07562932	NOT_YET_RECRUITING	Cardiogenic Shock	Chonnam National University Hospital	2026-05-31
NCT07363109	NOT_YET_RECRUITING	Hypotension After Spinal Anesthesia; Hypotension During Cesarean Delivery	Aretaieion University Hospital	2026-02
NCT07063680	RECRUITING	Patients With Norepinephrine-refractory Vasoplegic Shock	Centre Hospitalier Universitaire Dijon	2026-04-07	PHASE3
NCT07667829	NOT_YET_RECRUITING	Pulmonary Arterial Hypertension (PAH); Chronic Thromboembolic Pulmonary Hypertension (CTEPH); Hypertension, Pulmonary	China National Center for Cardiovascular Diseases	2026-06
NCT06746753	NOT_YET_RECRUITING	Septic Shock	Wake Forest University Health Sciences	2026-09	PHASE4
NCT06802224	RECRUITING	Anesthesia; Surgery With General Anesthesia; Noncardiac Surgery; Hypotension During Surgery; Acute Kidney Injury (AKI); Myocardial Injury After Noncardiac Surgery (MINS); Vasopressor	University of California, San Francisco	2025-04-01	PHASE4
NCT07796282	NOT_YET_RECRUITING	Spine Surgery; Intraoperative Hypotension; Tissue Perfusion	Mayo Clinic	2026-09	PHASE4
NCT07481097	NOT_YET_RECRUITING	Acute Kidney Injury Due to Sepsis	Assiut University	2026-04-01
NCT07343206	RECRUITING	Sepsis; Septic Shock	Siriraj Hospital	2026-01-01
NCT05997732	RECRUITING	Vasoconstriction; Vasodilation	University of Alberta	2023-10-31	PHASE4
NCT06059144	RECRUITING	Stroke, Acute; Stroke, Ischemic	University Hospital, Bordeaux	2024-11-28	PHASE3
NCT07749794	NOT_YET_RECRUITING	Prostatic Hyperplasia; Lower Urinary Tract Symptoms	Benha University	2026-08-15
NCT06464510	RECRUITING	Septic Shock	Hospital do Coracao	2024-11-21	PHASE3
NCT05219799	RECRUITING	Obesity; Vasodilation; Healthy	University of Missouri-Columbia	2023-03-14	EARLY_PHASE1
NCT06977659	ENROLLING_BY_INVITATION	Trauma, Multiple	Visarat Palitnonkiat	2025-05-20	PHASE1; PHASE2
NCT07322133	RECRUITING	Hypotension and Shock; Pulmonary Hypertension of the Newborn (PPHN); Hypoxemic Respiratory Failure	University of California, Davis	2026-10-30	PHASE4
NCT06520982	RECRUITING	Women; Sympathetic Nervous System; Aging; Blood Flow	University of Missouri-Columbia	2024-09-20	EARLY_PHASE1
NCT07716956	NOT_YET_RECRUITING	Septic Shock; Sepsis	Alexandria University	2026-07
NCT07662408	RECRUITING	Patients Undergoing Orthopedic Hip Surgery Under Spinal Anesthesia; Orthopedic Hip Sugery in Eldely Patients	Sohag University	2026-05-22	PHASE4
NCT07706426	NOT_YET_RECRUITING	Post Spinal Anaesthesia Hypotension	Ain Shams University	2026-07-09
NCT03207464	RECRUITING	Multiple Sclerosis	Brigham and Women's Hospital	2017-10-10	PHASE1; PHASE2
NCT07322419	RECRUITING	Cesarean Delivery; Spinal Anesthesia for Cesarean Section	Mansoura University	2026-01-01	PHASE4
NCT04934748	ENROLLING_BY_INVITATION	Blood Pressure	The University of Texas Health Science Center, Houston	2021-07-25	PHASE4
NCT07786844	RECRUITING	Urolithiasis; Lithotripsy	Geriatric Hospital of Nanjing Medical University	2025-04-21	PHASE1; PHASE2
NCT06559306	RECRUITING	Depressive Disorder, Major	Janssen Research & Development, LLC	2024-07-25	PHASE3
NCT06753409	RECRUITING	Postoperative Acute Kidney Injury	Assiut University	2025-02-01
NCT06727201	NOT_YET_RECRUITING	Spinal Anaesthesia Induced Hypotension	Assiut University	2025-01-01	PHASE2; PHASE3
NCT05193968	RECRUITING	Hot Flashes; Menopause; Vasomotor System; Labile	Mayo Clinic	2022-02-24
NCT07719075	RECRUITING	Hypotension on Induction; Emergency Surgery; Norepinephrine	Cairo University	2026-08-04
NCT04592744	ACTIVE_NOT_RECRUITING	Cirrhosis, Liver; End Stage Liver DIsease; Acute Kidney Injury; Liver Transplant; Complications	University of California, Los Angeles	2022-04-08	PHASE4
NCT04053478	RECRUITING	Hypotension	Samuel Lunenfeld Research Institute, Mount Sinai Hospital	2019-07-08
NCT07418541	NOT_YET_RECRUITING	Septic Shock; Acute Kidney Injury	Universitas Sumatera Utara	2026-04-23
NCT07538388	RECRUITING	Postinduction Hypotension	Universitätsklinikum Hamburg-Eppendorf	2026-05-07
NCT07379710	NOT_YET_RECRUITING	Incidence of Post-spinal Hypotension	Cairo University	2026-06-01	PHASE4
NCT06285396	RECRUITING	Postpartum Hemorrhage	Samuel Lunenfeld Research Institute, Mount Sinai Hospital	2024-03-18
NCT05179499	RECRUITING	Sepsis	NHS Greater Glasgow and Clyde	2022-10-11	PHASE3
NCT01426529	ACTIVE_NOT_RECRUITING	Hypertension; Insulin Resistance	Brigham and Women's Hospital	2010-10-01	PHASE1
NCT06080178	RECRUITING	Hypotension During Surgery	Algemeen Ziekenhuis Maria Middelares	2023-11-23	PHASE4
NCT02118467	RECRUITING	Shock	University of Chicago	2014-05-15	PHASE4
NCT07627360	NOT_YET_RECRUITING	Intraoperative Hypotension; Postoperative Pulmonary Complications (PPCs); Fluid Over-load	Suez Canal University	2026-07-15
NCT07153406	NOT_YET_RECRUITING	Depressive Disorder	Fundación Pública Andaluza para la gestión de la Investigación en Sevilla	2025-09-15	PHASE3
NCT05575271	NOT_YET_RECRUITING	Alzheimer Disease	Xuanwu Hospital, Beijing	2022-11-01
NCT07529795	NOT_YET_RECRUITING	Secondary Peritonitis; Post-induction Hypotension	Bach Mai Hospital	2026-04-01	PHASE4
NCT07614438	NOT_YET_RECRUITING	Anesthesia; Pulmonary Hypertension; Chronic Pulmonary Thromboembolism; Vasopressor	Fondation Hôpital Saint-Joseph	2026-08-01	PHASE2
NCT04218773	SUSPENDED	Ischemic Stroke; Blood Pressure	Yale University	2020-09-11	EARLY_PHASE1
NCT02966665	RECRUITING	Chronic Obstructive Pulmonary Disease; Pulmonary Artery Hypertension; Heart Failure; Hypertension	Russell Richardson	2008-09	PHASE1
NCT06880510	ACTIVE_NOT_RECRUITING	Alzheimer Disease	Cornell University	2025-06-01
NCT06471231	UNKNOWN	Septic Shock; Renal Function Replacement	Azienda Usl di Bologna	2024-05-15	PHASE4
NCT06711432	RECRUITING	Tumor; Stroke	Zhejiang Cancer Hospital	2024-09-18
NCT06367205	UNKNOWN	Delayed Graft Function; End Stage Renal Disease; Kidney Transplantation	RenJi Hospital	2024-03-01
NCT06508359	COMPLETED	Outcome	General Hospital of Ningxia Medical University	2025-08-01
NCT06248593	RECRUITING	Cesarean Section Complications; Hypotension	Hassan II University	2025-01-29	PHASE4
NCT05568160	ACTIVE_NOT_RECRUITING	Scheduled Cardiac Surgery With Extracorporeal Circulation; Vasoplegic Syndrome	Centre Hospitalier Universitaire Dijon	2023-01-02	PHASE3
NCT06234592	RECRUITING	Septic Shock; Acute Kidney Injury	King's College Hospital NHS Trust	2024-01-05
NCT06155812	COMPLETED	Shock, Septic	University Medical Centre Maribor	2023-12-23	PHASE2; PHASE3
NCT06158035	UNKNOWN	Adverse Effect	General Hospital of Ningxia Medical University	2025-07-01
NCT07077265	COMPLETED	Spinal Aneshtesia; Hypotension After Spinal Anesthesia; Elderly (People Aged 65 or More)	Kasr El Aini Hospital	2025-08-01
NCT06950606	COMPLETED	Hypotension During Surgery	Universitätsklinikum Hamburg-Eppendorf	2025-05-19
NCT06921473	COMPLETED	Cesarean Delivery Affecting Newborn; Acidosis; Maternal Hypotension; Spinal Aneshtesia	mehmet özkılıç	2025-09-01	PHASE4
NCT06922097	COMPLETED	Intraoperative Bradycardia	University of Hamburg-Eppendorf	2025-04-07
NCT06334549	RECRUITING	Hypotension Drug-Induced	Dalian Municipal Central Hospital	2024-03-05	PHASE4
NCT06422481	UNKNOWN	Cardiovascular Physiological Phenomena; Intensive Care Unit Syndrome	Centre Hospitalier Universitaire de Nice	2024-07
NCT06462313	COMPLETED	Patients With Septic Shock; Surgical Patients; General Anesthesia	First Affiliated Hospital of Zhejiang University	2024-06-18
NCT06930235	COMPLETED	Shock	Sohag University	2025-03-13
NCT07327320	COMPLETED	Anesthesia; Spinal; Cesarean Section; Hypotension, Controlled	Tam Anh Research Institute	2024-06-06	PHASE4
NCT06102382	RECRUITING	Cesarean Section; Hypotension; Norepinephrine	Assiut University	2024-09-01
NCT05970770	UNKNOWN	Hypotension During Surgery; Hypotension Drug-Induced	Fondazione Policlinico Universitario Agostino Gemelli IRCCS	2023-09-01	PHASE4
NCT06157320	UNKNOWN	Sepsis	Ruijin Hospital	2023-12-01
NCT06233903	WITHDRAWN	Neuroblastoma; Pheochromocytoma; Paraganglioma	Innervate Radiopharmaceuticals LLC (Formerly: Illumina Radiopharmaceuticals LLC)	2025-01	PHASE2
NCT06556472	UNKNOWN	Acute on Chronic Liver Failure	Institute of Liver and Biliary Sciences, India	2024-08-15
NCT06574555	COMPLETED	Hypotension; Hypertension; Nausea; Pain; Arrhythmia	Pontificia Universidad Catolica de Chile	2025-04-01	PHASE4
NCT06934798	RECRUITING	Vasoplegic Syndrome of Cardiac Surgery	University of Sao Paulo	2024-04-01	PHASE4
NCT06158009	UNKNOWN	Adverse Effect	General Hospital of Ningxia Medical University	2025-04-01
NCT06151457	UNKNOWN	Adverse Effect	General Hospital of Ningxia Medical University	2025-01-01
NCT05922982	UNKNOWN	Vasoplegia; Shock; Norepinephrine; Surgery	Centre Hospitalier Universitaire, Amiens	2023-09-01
NCT05836272	RECRUITING	Sepsis, Severe	Tunis University	2023-08-01	PHASE4
NCT05637606	COMPLETED	Blood Pressure; Complication,Postoperative; Intraoperative Hypotension	Humanitas Clinical and Research Center	2023-03-06
NCT06158022	COMPLETED	Adverse Effect	General Hospital of Ningxia Medical University	2024-10-03
NCT06344442	RECRUITING	Acute Kidney Injury Post Liver Transplantation	Assistance Publique - Hôpitaux de Paris	2025-04-16	PHASE3
NCT07153601	COMPLETED	Hypotenstion; Cesarean Resection; Anesthesia Spinal; Pregnancy Complications; Cardiovascular	Universitas Sumatera Utara	2025-02-07
NCT07259655	TERMINATED	Post-induction Hypotension	Hopital Charles Nicolle	2025-03-06	PHASE4
NCT06158048	COMPLETED	Adverse Effect	General Hospital of Ningxia Medical University	2025-01-01
NCT05035498	UNKNOWN	Hemodynamic Instability	General Hospital of Ningxia Medical University	2024-02-01
NCT06151509	UNKNOWN	Adverse Effect	General Hospital of Ningxia Medical University	2025-01-01
NCT06836986	RECRUITING	Spinal Anesthesia Induced Hypotension	Dow University of Health Sciences	2024-12-31
NCT07330908	COMPLETED	Septic Shock; Peripheral Perfusion Index	Tanta University	2024-10-30
NCT06496061	COMPLETED	Post Spinal Hypotension	Fayoum University	2024-08-01	PHASE4
NCT06498076	COMPLETED	Anesthesia Complication; Vasopressor; Cesarean Section Complications; Hypotension During Surgery	Hopital Charles Nicolle	2024-08-01
NCT05886192	UNKNOWN	Septic Shock	Peking Union Medical College Hospital	2023-05-01	PHASE4
NCT05414877	UNKNOWN	Carotid Endarterectomy	Beijing Tiantan Hospital	2023-09-30
NCT05564741	COMPLETED	Hypotension; Hip Fractures; Anesthesia	Sahlgrenska University Hospital	2022-10-20	PHASE4
NCT06053398	COMPLETED	Hypotension	University of Texas Southwestern Medical Center	2023-11-21	EARLY_PHASE1
NCT05276596	COMPLETED	Norepinephrine; Hypotension; Anesthesiology; Major Abdominal Surgery	Centre Hospitalier Universitaire, Amiens	2021-11-17	PHASE3
NCT06512415	UNKNOWN	Hypotension; Spinal Anesthesia; Cesarean Section	Cairo University	2024-08
NCT06512402	UNKNOWN	Hypotension; Spinal Block; Cesarean Section	Cairo University	2024-08
NCT04977271	WITHDRAWN	Depressive Disorder; Head and Neck Cancer	University of Alabama at Birmingham	2024-01-05	PHASE4
NCT06213935	UNKNOWN	Post Spinal Anesthesia Hypotension	Sohag University	2024-02-01
NCT05665881	COMPLETED	Carotid Endarterectomy	Beijing Tiantan Hospital	2023-01-07
NCT05814601	UNKNOWN	Brain Tumor	Yonsei University	2023-05
NCT06498115	UNKNOWN	Maternal Hypotension	The Third People's Hospital of Bengbu	2024-07	PHASE4
NCT07053163	COMPLETED	Mortality Rate; Hemorrhagic Shock	Tanta University	2024-08-30
NCT05133271	COMPLETED	Cesarean; Spinal Anesthesia	Assistance Publique - Hôpitaux de Paris	2021-02-03
NCT05492968	UNKNOWN	Cardiac Output, Low; Cardiac Output, High; Perfusion; Complications	Medical University of Vienna	2022-09-01	PHASE4
NCT04597190	COMPLETED	PTSD	University of Washington	2020-06-01	PHASE4
NCT05355974	COMPLETED	Respiratory Failure; Hypotension and Shock; Hypotension on Induction; Intubation Complication; Anesthesia Intubation Complication	Wright State University	2022-08-09	PHASE3
NCT05521152	COMPLETED	Anesthesia; Pediatrics; Biliary Atresia	Kasr El Aini Hospital	2022-08-28	PHASE3
NCT05842616	COMPLETED	Sepsis; Norepinephrine; Encephalopathy	Tanta University	2023-05-01
NCT05940649	COMPLETED	Intraoperative Hypotension	Kristen Thomsen	2023-07-03
NCT06461390	COMPLETED	Septic Shock; Sepsis	Indonesia University	2024-03-25	PHASE2; PHASE3
NCT03684213	COMPLETED	Cardiovascular Diseases; Cardiovascular Risk Factor; Vasoconstriction	The University of Texas at Arlington	2018-10-15	PHASE1
NCT05997303	COMPLETED	Blood Pressure; Perioperative Hypotension	Universitätsklinikum Hamburg-Eppendorf	2023-09-08
NCT06028256	UNKNOWN	Anesthesia; Blood Pressure; Norepinephrine	First Affiliated Hospital of Kunming Medical University	2023-10-01	PHASE4
NCT06311903	UNKNOWN	Norepinephrine; Hemorrhagic Shock; Hypotensive Resuscitation	Tanta University	2023-12-01
NCT04403165	COMPLETED	Alzheimer Disease	NYU Langone Health	2020-08-06
NCT07795710	COMPLETED	Ephedrine; Norepinephrine	Minia University	2024-01-30
NCT05712018	COMPLETED	Adverse Effect	General Hospital of Ningxia Medical University	2023-10-20
NCT05035485	COMPLETED	Hemodynamic Instability	General Hospital of Ningxia Medical University	2022-09-13
NCT03626454	COMPLETED	Hypotension Drug-Induced	Fayoum University Hospital	2020-10-16
NCT05035472	UNKNOWN	Adverse Effect	General Hospital of Ningxia Medical University	2023-01-01
NCT04653337	UNKNOWN	Suicidal Ideation; Depression	Xijing Hospital	2020-09-28	PHASE2
NCT03864094	COMPLETED	Hemodynamic Instability; Anesthesia, General; Anesthesia, Intravenous	Helse Fonna	2022-03-15	PHASE4
NCT05318066	ACTIVE_NOT_RECRUITING	Critically Ill Adults in the ICU, Requiring Endotracheal Intubation	Tata Memorial Centre	2022-07-15
NCT03483753	WITHDRAWN	Circulatory Shock; Non-cardiac Surgery	University of Sao Paulo	2019-01	PHASE2; PHASE3
NCT05497700	UNKNOWN	Hypotension on Induction	Brugmann University Hospital	2022-09-15	PHASE3
NCT04218123	COMPLETED	Meniere Disease	Medical University of South Carolina	2020-02-05	PHASE2; PHASE3
NCT04501861	COMPLETED	Cardiac Disease	The Cleveland Clinic	2020-11-05	PHASE3
NCT05842759	COMPLETED	Hypotension; Anesthesia; Hypotension on Induction	Universitätsklinikum Hamburg-Eppendorf	2023-03-07
NCT06163352	COMPLETED	Vasopressor Adverse Reaction; Pressure Injury; Pressure Ulcer	Koç University	2023-05-01
NCT05774067	COMPLETED	Norepinephrine, Glypressin, Tourniquet Deflation; Hypotension	Tanta University	2022-12-01
NCT05690334	COMPLETED	Adverse Effect	General Hospital of Ningxia Medical University	2023-03-21
NCT04556370	COMPLETED	Adverse Effect	General Hospital of Ningxia Medical University	2021-11-16
NCT03621618	WITHDRAWN	Sepsis; Cardiac Failure Acute	Universitair Ziekenhuis Brussel	2019-03-31
NCT05637164	UNKNOWN	Norepinephrine; Post-induction Hypotension	Second Affiliated Hospital, Zhejiang University, School of Medicine	2022-12-01
NCT03891849	WITHDRAWN	Haemorrhagic Shock; Variceal Hemorrhage	Centre Hospitalier Universitaire, Amiens	2021-09-01
NCT05475990	COMPLETED	Adverse Effect	General Hospital of Ningxia Medical University	2023-01-11
NCT05293288	COMPLETED	Hypotension	Universitätsklinikum Hamburg-Eppendorf	2022-02-15
NCT05264870	TERMINATED	Cesarean Section Complications; Hemodynamic Instability; Foetal Stress	University Hospital, Antwerp	2022-06-09	PHASE4
NCT05525416	COMPLETED	Vasodilation; Vasoconstriction	University of Alberta	2022-07-28
NCT05774054	COMPLETED	Norepinephrine; Sepsis; Hypotension	Tanta University	2021-05-01
NCT05035888	COMPLETED	Adverse Effect	General Hospital of Ningxia Medical University	2022-09-05
NCT05506319	COMPLETED	Septic Shock	Hospital Nossa Senhora da Conceicao	2022-05-01	PHASE4
NCT05136183	UNKNOWN	Septic Shock; Cytokine Storm	Mahidol University	2021-12-15
NCT04209166	UNKNOWN	Major Depressive Disorder	Shanghai Mental Health Center	2019-08-12
NCT05502146	COMPLETED	Spinal Anesthetic Toxicity; Hypotension Drug-Induced; Cesarean Section Complications	Mersin University	2022-08-17	PHASE4
NCT05133817	COMPLETED	Adverse Event	General Hospital of Ningxia Medical University	2021-11-26
NCT04528628	UNKNOWN	Major Depressive Disorder	Shanghai Mental Health Center	2020-10
NCT05368415	COMPLETED	Anesthesia; Adverse Effect; Cesarean Section Complications	Kasr El Aini Hospital	2022-05-15	PHASE4
NCT05290740	COMPLETED	Postspinal Hypotension; Cesarean Delivery; Norepinephrine	Kasr El Aini Hospital	2022-03-11	PHASE4
NCT04258592	TERMINATED	Neural Crest Tumor; Neuroendocrine Tumors	Universitaire Ziekenhuizen KU Leuven	2020-02-07	PHASE1
NCT03712111	UNKNOWN	Cesarean Section Complications; Spinal Anesthetic Toxicity	Cairo University	2018-11-21	PHASE4
NCT05248932	COMPLETED	Hypotension; Cesarean Section Complications	Menoufia University	2021-01-20	PHASE4
NCT04683614	COMPLETED	Anesthesia	National Cancer Institute, Egypt	2020-10-20
NCT04951167	UNKNOWN	HYPOTENSION AFTER SPINAL ANESTHESIA,IN PREGNANCY	Inonu University	2021-05-15
NCT04367103	COMPLETED	Hypotension; Cesarean Section	Assiut University	2021-04-10
NCT04789330	COMPLETED	Anesthesia; Surgery; Hypotension	University of California, San Francisco	2021-07-01	PHASE4
NCT03248791	UNKNOWN	Cesarean Section Complications; Spinal Anesthesia	Cairo University	2017-08-20	PHASE4
NCT05049278	COMPLETED	Blood Flow; Anastomotic Failure of Flap; Flap Necrosis; Flap Ischemia	Seoul National University Hospital	2021-09-24
NCT04639037	COMPLETED	Hypotension	Assistance Publique - Hôpitaux de Paris	2021-01-08
NCT04338321	COMPLETED	Depressive Disorder, Major	Janssen-Cilag International NV	2020-08-21	PHASE3
NCT03602014	COMPLETED	Hypotension, Orthostatic; Hypotension; Spinal Cord Injuries	James J. Peters Veterans Affairs Medical Center	2018-06-01	PHASE4
NCT04991662	COMPLETED	Cesarean Section Complications	Xuzhou Medical University	2021-10-10	PHASE4
NCT04272632	COMPLETED	Adverse Effect	General Hospital of Ningxia Medical University	2021-04-01
NCT04556357	COMPLETED	Adverse Effect	General Hospital of Ningxia Medical University	2020-09-22
NCT04777383	TERMINATED	Cardiovascular Diseases; Vascular Diseases	University Hospital, Linkoeping	2019-04-01
NCT04214145	COMPLETED	Cerebral Oxygen Saturation	Seoul National University Hospital	2020-01-07
NCT04170751	UNKNOWN	Hypertension	Yonsei University	2019-11-18
NCT04536194	COMPLETED	Anesthesia; Infant; Congenital Heart Disease; Hemodynamic Instability	Children's Hospital of Fudan University	2020-10-10	PHASE3
NCT07384455	COMPLETED	Caesarean Section	Bakirkoy Dr. Sadi Konuk Research and Training Hospital	2021-01-03
NCT04376281	COMPLETED	Liver Transplantation	Cairo University	2019-12-15
NCT04703088	UNKNOWN	Hypotension; Anesthesia; Adverse Effect, Spinal and Epidural; Cesarean Section	Laval University	2021-06	PHASE3
NCT04404946	COMPLETED	Hypotension Symptomatic; Vasoconstriction; Cesarean Section Complications; Obstetric Anesthesia Problems	Aretaieion University Hospital	2020-05-23
NCT02784535	COMPLETED	Neurogenic Orthostatic Hypotension	Vanderbilt University Medical Center	2016-08-29	PHASE2
NCT04478526	COMPLETED	Generalized Anxiety Disorder	Dr. Nazanin Alavi	2020-04-29
NCT04406051	COMPLETED	Hypotension; Obstetric Anesthesia Problems; Cesarean Section Complications; Hypotensive; Vasoconstriction	Aretaieion University Hospital	2020-05-26
NCT04144257	COMPLETED	Multiple Sclerosis	Brigham and Women's Hospital	2020-03-12	PHASE1; PHASE2
NCT04312971	COMPLETED	Cardiac Surgery; Cardiopulmonary Bypass	Imam Abdulrahman Bin Faisal University	2020-05-06
NCT04272580	COMPLETED	Adverse Effect	General Hospital of Ningxia Medical University	2020-07-01
NCT03849508	COMPLETED	Cesarean Section Complications; Spinal Anesthesia	Centre Hospitalier Régional d'Orléans	2019-02-27	PHASE4
NCT02472249	COMPLETED	Hepatocellular Carcinoma	University Health Network, Toronto	2016-01	PHASE4
NCT03965117	COMPLETED	General Anesthesia	University Hospital, Ghent	2019-05-28	PHASE4
NCT04295993	UNKNOWN	Septic Shock	Cairo University	2020-03-10	PHASE3
NCT04272567	COMPLETED	Adverse Effect	General Hospital of Ningxia Medical University	2020-03-28
NCT03872570	UNKNOWN	Arterial Hypotension	Algemeen Ziekenhuis Maria Middelares	2019-06-01	PHASE4
NCT03702400	COMPLETED	Hypotension; Spinal Anesthesia	Hospital dos Servidores do Estado do Rio de Janeiro	2018-10-01	PHASE2
NCT03806582	COMPLETED	Blood Pressure; Right Ventricular Dysfunction	Frisius Medisch Centrum	2019-03-01	PHASE4
NCT04789005	COMPLETED	Spinal Induced-hypotension	Tribhuvan University Teaching Hospital, Institute Of Medicine.	2019-11-10	PHASE3
NCT03455322	COMPLETED	Renal Impairment in Hepatorenal Syndrome	National Hepatology & Tropical Medicine Research Institute	2018-08-15	PHASE4
NCT03773276	COMPLETED	Living Donor Liver Transplantation; Norepinephrine Bolus; Postperfusion Syndrome	Mansoura University	2018-12-17	PHASE1; PHASE2
NCT01975480	COMPLETED	Generalized Anxiety Disorder	START Clinic for Mood and Anxiety Disorders	2013-01	PHASE4
NCT04195321	COMPLETED	Spinal Induced Hypotension; Elderly	Kasr El Aini Hospital	2020-01-01	PHASE4
NCT04089644	COMPLETED	Hypotension	Erasme University Hospital	2019-09-17
NCT04522297	COMPLETED	Hepato-Renal Syndrome	National Hepatology & Tropical Medicine Research Institute	2018-04-15
NCT03249311	UNKNOWN	None (i.e. Healthy Volunteers)	University of Ottawa	2018-03-02	PHASE4
NCT04067817	UNKNOWN	Hypotension	The Second Affiliated Hospital of Dalian Medical University	2019-10-06	PHASE3
NCT03340779	UNKNOWN	Cardiogenic Shock	Central Hospital, Nancy, France	2018-01-15	PHASE3
NCT03997500	COMPLETED	Adverse Effect	General Hospital of Ningxia Medical University	2019-01-01
NCT03833895	COMPLETED	Cesarean Section Complications	China International Neuroscience Institution	2019-02-20	PHASE2; PHASE3
NCT03842046	COMPLETED	Hypotension Symptomatic; Obstetric Anesthesia Problems; Cesarean Section Complications; Vasoconstriction	Aretaieion University Hospital	2019-02-16
NCT02832596	COMPLETED	Blood Pressure; Anesthesia	Sahlgrenska University Hospital	2016-10
NCT03302650	SUSPENDED	Septic Shock	Cairo University	2019-04-01	PHASE3
NCT03321526	COMPLETED	Depressive Disorder, Major	Janssen Research & Development, LLC	2017-12-12	PHASE2
NCT02812147	UNKNOWN	Parkinson Disease	St. Joseph's Hospital and Medical Center, Phoenix	2016-05	PHASE2
NCT03719625	UNKNOWN	Maternal Hypotension Syndrome; Cesarean	Mongi Slim Hospital	2019-01-02	PHASE4
NCT03792906	COMPLETED	Cesarean Section Complications; Spinal Anesthetic Toxicity	Cairo University	2019-01-18	PHASE4
NCT02473263	COMPLETED	Severe Septic Syndrome (Severe Sepsis and Septic Shock) Diagnosed and Treated by Mobile Intensive Care Unit	Assistance Publique - Hôpitaux de Paris	2016-05-09	PHASE3
NCT04302584	COMPLETED	Septic Shock; Acute Kidney Injury	Ain Shams University	2018-01-01
NCT03107858	UNKNOWN	Renal Transplant	Assiut University	2017-11-01	PHASE2; PHASE3
NCT02624310	WITHDRAWN	HSAN Type IV	NYU Langone Health	2016-01	PHASE2
NCT02640846	UNKNOWN	Septic Shock; Cardiomyopathy	Sahlgrenska University Hospital	2015-12	PHASE4
NCT03106831	UNKNOWN	Postoperative Vasoplegic Syndrome	Beijing Anzhen Hospital	2017-10-10
NCT03115827	COMPLETED	Parkinson Disease	Vanderbilt University Medical Center	2017-04-18	PHASE4
NCT03336814	UNKNOWN	Septic Shock	Assistance Publique Hopitaux De Marseille	2018-07-27	PHASE4
NCT02428062	SUSPENDED	Post-operative Cognitive Dysfunction	Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico	2014-10	PHASE2; PHASE3
NCT03672071	UNKNOWN	Cesarean	Yuzuncu Yil University	2018-09-30
NCT03780686	COMPLETED	Renal Function Test, Urine Output, Lactate Level	Ain Shams University	2017-04-09
NCT03234816	COMPLETED	Cesarean Section Complications	Cairo University	2017-08-02	PHASE4
NCT03070665	UNKNOWN	Gastrointestinal Disease; Gastrointestinal Bleeding	Shanghai Zhongshan Hospital	2017-04-01
NCT03706755	COMPLETED	Anesthesia; Adverse Effect; Hypotension; Cesarean Section Complications; Vasopressor	University Tunis El Manar	2018-05-03	PHASE4
NCT03328533	COMPLETED	Cesarean Section Complications; Spinal Anesthesia	Cairo University	2017-11-10	PHASE4
NCT03163914	COMPLETED	Spinal Anesthesia	Cukurova University	2017-07-19	PHASE4
NCT03421860	COMPLETED	Cardiac Output, Low	University Tunis El Manar	2017-02-23	PHASE4
NCT02789150	COMPLETED	Hepatorenal Syndrome	University of Louisville	2015-01	EARLY_PHASE1
NCT03308708	UNKNOWN	Spinal Anesthesia	Mansoura University	2017-11-01
NCT02726620	COMPLETED	Hypotension	Vanderbilt University Medical Center	2017-01-05
NCT03182088	COMPLETED	Cesarean Section Complications	Cairo University	2017-06-15	PHASE4
NCT02454348	WITHDRAWN	Shock, Septic	University of Arkansas	2015-11-01	PHASE4
NCT02895659	COMPLETED	Critical Illness	Insel Gruppe AG, University Hospital Bern	2016-12-01	PHASE4
NCT02928601	COMPLETED	Maternal Hypotension	Cukurova University	2016-11	PHASE4
NCT01945983	COMPLETED	Septic Shock; Severe Sepsis	Mahidol University	2013-10-03
NCT02969239	UNKNOWN	Hypotension	Jeju National University Hospital	2016-01	PHASE4
NCT02304939	UNKNOWN	Shock; Intensive Care	University Hospital, Angers	2015-04
NCT02962986	COMPLETED	Hypotension	Samuel Lunenfeld Research Institute, Mount Sinai Hospital	2017-01
NCT02453425	COMPLETED	Septic Shock; Acute Kidney Injury	Sahlgrenska University Hospital	2011-05
NCT03015857	COMPLETED	Adverse Anesthesia Outcome	Kasr El Aini Hospital	2017-01	PHASE2
NCT03288051	COMPLETED	Optimal Tissue Perfusion	Szeged University	2014-04-28
NCT02638545	COMPLETED	Septic Shock	University of Roma La Sapienza	2015-09	PHASE3
NCT03163407	COMPLETED	Hypotension; Vasopressors; Cesarean Section Complications; Anesthesia Complication	Mongi Slim Hospital	2016-07-01
NCT03215797	COMPLETED	Hypotension; Fluid Therapy	The Second Affiliated Hospital of Dalian Medical University	2016-09	PHASE3
NCT02519699	COMPLETED	Septic Shock	Federal University of São Paulo	2013-03	PHASE4
NCT02477501	COMPLETED	Anesthesia; Adverse Effect, Spinal and Epidural; Hypotension; Complications; Cesarean Section	University Tunis El Manar	2016-01	PHASE4
NCT02085291	COMPLETED	Septic Shock; Hypertension	Southeast University, China	2014-03	PHASE4
NCT02854787	COMPLETED	Anesthesia, Spinal and Epidural; Adverse Effect; Hypotension; Complications, Cesarean Section	University Tunis El Manar	2016-05	PHASE4
NCT02675868	COMPLETED	Endotoxemia	Radboud University Medical Center	2016-01	PHASE4
NCT02759510	UNKNOWN	Cardiac Output,Low; Hemodynamic Instability; Obstetrical Complication of Anesthesia	RenJi Hospital	2016-06	EARLY_PHASE1
NCT02542748	COMPLETED	Hypotension; Obstetrical Complication of Anesthesia; Complications; Cesarean Section	Air Force Military Medical University, China	2015-10-05
NCT02019810	UNKNOWN	Severe Traumatic Brain Injury With High Cerebral Pressure	University Hospital, Grenoble	2014-10	PHASE2
NCT02479529	COMPLETED	Vasoplegic Syndrome	Centre Hospitalier Universitaire, Amiens	2014-10	PHASE3
NCT02654847	COMPLETED	Hypotension	Samuel Lunenfeld Research Institute, Mount Sinai Hospital	2016-01
NCT01367743	COMPLETED	Cardiogenic Shock	Central Hospital, Nancy, France	2011-09	PHASE4
NCT02455115	COMPLETED	Acute Kidney Injury; Liver Failure	Sahlgrenska University Hospital	2015-01
NCT02203630	TERMINATED	Septic Shock; Sepsis; Shock; Tachycardia; Arrhythmia	Vanderbilt University Medical Center	2014-08	PHASE4
NCT01697410	UNKNOWN	Septic Shock	First Affiliated Hospital, Sun Yat-Sen University	2013-01
NCT02354833	COMPLETED	Effects of; Anesthesia, in Labor and Delivery	West Virginia University	2014-08	PHASE4
NCT02306239	UNKNOWN	Terlipressin; Septic Shock	Liu ZiMeng	2014-12
NCT02412189	UNKNOWN	Blood Pressure; Hematocrit Change; Anesthesia	Sahlgrenska University Hospital	2014-02
NCT01148979	COMPLETED	Major Depressive Disorder	Mclean Hospital	2010-09	PHASE4
NCT02241083	COMPLETED	Head and Neck Cancer	Tampere University Hospital	2006-06	PHASE4
NCT01718613	COMPLETED	Septic Shock	Instituto do Cancer do Estado de São Paulo	2012-11	PHASE3
NCT02069288	WITHDRAWN	Septic Shock	Rennes University Hospital		PHASE3
NCT02038595	COMPLETED	Brown Adipose Tissue	Yale University	2012-09	EARLY_PHASE1
NCT01271114	TERMINATED	Septic Shock; Sepsis-associated Hypotension	Hospital General de Ciudad Real	2012-06	PHASE3
NCT01493102	TERMINATED	Septic Shock	Samsung Medical Center	2011-12
NCT02015546	COMPLETED	Major Depressive Disorder (MDD)	Duke University	2012-12	PHASE3
NCT01263366	TERMINATED	Radiodermatitis	ProCertus BioPharm, Inc	2011-01	PHASE1
NCT00547911	TERMINATED	Parkinson Disease; Multiple System Atrophy; Autonomic Nervous System Diseases	National Institute of Neurological Disorders and Stroke (NINDS)	2007-10	PHASE1; PHASE2
NCT01912352	COMPLETED	Attention Deficit Hyperactivity Disorder	Seoul National University	2010-05
NCT01799837	COMPLETED	Posttraumatic Stress Disorder	Emory University	2012-06	PHASE1
NCT01505231	UNKNOWN	Shock	University of Sao Paulo	2012-01	PHASE3
NCT01318434	COMPLETED	Major Depressive Disorder	Euthymics BioScience, Inc.	2011-02	PHASE2; PHASE3
NCT01285908	COMPLETED	Orthostatic Hypertension	National Institute of Neurological Disorders and Stroke (NINDS)	2011-01	PHASE1; PHASE2
NCT01609491	COMPLETED	Bloodpressure	University Medical Center Groningen	2012-01
NCT01544504	WITHDRAWN	Radiodermatitis	ProCertus BioPharm, Inc	2012-03	PHASE1; PHASE2
NCT01568853	COMPLETED	Severe Sepsis; Pancreatitis; Abdominal Abscess; Appendicitis; Digestive System Fistula	Jinling Hospital, China	2011-11
NCT01367990	TERMINATED	Alopecia; Radiodermatitis	ProCertus BioPharm, Inc	2011-07	PHASE1
NCT01101152	UNKNOWN	Healthy	University of Ottawa	2010-04	PHASE1
NCT01189825	COMPLETED	Sexual Dysfunction	University of Texas at Austin	2009-06
NCT00841633	TERMINATED	Cerebral Ischemia; Subarachnoid Hemorrhage	UMC Utrecht	2009-02	PHASE3
NCT00624650	COMPLETED	Acute Lung Injury	Oregon Health and Science University	2008-02	PHASE2
NCT01040208	TERMINATED	Sexual Dysfunctions, Psychological; Depression	Sprout Pharmaceuticals, Inc	2010-01	PHASE3
NCT00848770	UNKNOWN	Stroke, Acute	Hospital de Clinicas de Porto Alegre	2008-01
NCT00411398	COMPLETED	General Anxiety Disorder, Social Anxiety Disorder	State University of New York - Upstate Medical University	2006-12	PHASE3
NCT00862108	UNKNOWN	Attention Deficit Hyperactivity Disorder	Seoul National University Hospital	2008-09	PHASE4
NCT01418118	COMPLETED	Oral Cancer; Head and Neck Cancer; Free Flap; Hypotension	Oxford University Hospitals NHS Trust	2008-10	PHASE4
NCT00633711	COMPLETED	Obstructive Sleep Apnea Syndrome	Fondazione C.N.R./Regione Toscana "G. Monasterio", Pisa, Italy	2007-03	PHASE4
NCT01153802	COMPLETED	Depressive Disorder	GlaxoSmithKline	2009-04-03	PHASE1
NCT00604019	COMPLETED	Septic Shock	Rush University Medical Center	2003-03	PHASE3
NCT00489138	TERMINATED	To Assess the Tissular and Plasma Kinetics of Ertapenem	Assistance Publique Hopitaux De Marseille	2007-04	PHASE4
NCT00549419	COMPLETED	Major Abdominal Surgery	Klinikum Ludwigshafen	2007-10	PHASE4
NCT01769807	COMPLETED	Obstructive Sleep Apnea	University of Lisbon	2004-07
NCT00757029	COMPLETED	Attention Deficit Disorder With Hyperactivity; Methylphenidate; Pharmacogenetics	Hallym University Medical Center	2005-10	PHASE4
NCT00639015	COMPLETED	Septic Shock	University of Roma La Sapienza	2007-11	PHASE2
NCT00331799	COMPLETED	Major Depressive Disorder	Duke University	2007-04	PHASE2
NCT00420004	COMPLETED	Major Depressive Disorder	Eli Lilly and Company	2006-12	PHASE2
NCT00481572	COMPLETED	Septic Shock	University of Roma La Sapienza	2007-01	PHASE2
NCT00314704	COMPLETED	Shock	Sepsis Occurrence in Acutely Ill Patients	2003-12	PHASE3
NCT00763906	COMPLETED	Septic Shock	Association pour le Développement de la Recherche et de l'Enseignement en Médecine d'Urgence	2004-11	PHASE4
NCT00494455	COMPLETED	Critical Illness	Medical University of Vienna	2005-04
NCT00148278	COMPLETED	Septic Shock; Severe Sepsis; Infections	University of Versailles	1999-10	PHASE2; PHASE3
NCT00049972	COMPLETED	Major Depressive Disorder	GlaxoSmithKline	2002-09	PHASE4
NCT00197886	COMPLETED	Septic Shock	Herlev Hospital	2004-10
NCT00294606	UNKNOWN	Vasopressor Agents; Endarterectomy, Carotid; Echocardiography, Transesophageal	London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's	2006-02
NCT00894621	UNKNOWN	Shock; Mechanical Ventilation	Unidade de Terapia Intensiva	2008-11	PHASE4
NCT00229645	COMPLETED	Major Depression With Comorbid Anxiety Symptoms	Dr Alexander McIntyre Inc.	2003-11	PHASE4
NCT00486174	WITHDRAWN	Sepsis	Queen's University	2007-06
NCT00414323	COMPLETED	Major Depressive Disorder	Eli Lilly and Company	2006-11	PHASE1
NCT00264186	COMPLETED	Inflammation	Medical University of Vienna	2005-06	PHASE1
NCT00134212	COMPLETED	Septic Shock	Rennes University Hospital	2002-03	PHASE2

(data from https://clinicaltrials.gov, updated on 2026-05-01)

Check the Norepinephrine tartrate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Compliance for Clinical Use

Mechanism and Biochemical Profile

Norepinephrine tartrate acts as a potent agonist that selectively binds to and activates alpha-1, alpha-2, and beta-1 adrenergic receptors, driving downstream G-protein-mediated signaling cascades that promote intracellular calcium influx and cyclic AMP modulation. This activation induces vascular smooth muscle contraction and enhances cardiac contractility, thereby raising systemic vascular resistance and blood pressure to effectively reverse hemodynamic collapse in clinical conditions such as septic shock and anesthesia-induced hypotension.

Appendix RUO and cGMP Quality Standards

Quality Dimension	RUO (Research Use Only)	cGMP (Current Good Manufacturing Practice)
Clinical Applicability	Prohibited in human clinical trials or medical diagnostics.	Mandatory for human clinical trials (Phase I–III) and therapies.
Regulatory Status	Non-regulated grade; exempt from drug manufacturing laws.	Legally enforced by health authorities (e.g., FDA, EMA, NMPA).
Facility Environment	Unclassified analytical or research laboratories.	Validated Cleanrooms (ISO Class 5–8) with continuous monitoring.
Quality Control	Basic purity and activity testing.	Rigorous safety release testing (Sterility, Endotoxin, Mycoplasma).
Process Validation	Basic equipment calibration; no process validation required.	Full qualification (IQ/OQ/PQ) and complete batch records.
Quality Assurance	Vendor self-declared without required formal QMS.	Mandatory QA/QC unit, Change Control, CAPA, and vendor audits.
Regulatory Impact	High risk of IND rejection if used as a critical raw material.	Required for IND/NDA filings, supported by Drug Master Files (DMF).

Footnotes

Regulatory Note: Governed by FDA (21 CFR Parts 210/211/312), EMA (EudraLex Vol 4), ICH Guidelines (E6/Q7/Q9/Q10), and compendial standards (USP <71>/<85>/<1043>).