Clinical Trials

Numerous clinical trials, spanning Early Phase 1 through Phase 4, evaluate nicotinamide and related precursor formulations across diverse therapeutic areas. Sponsored by academic institutions, medical centers, and pharmaceutical companies, these studies range from actively recruiting to completed. Overall, these investigations assess the therapeutic potential of modulating nicotinamide adenine dinucleotide (NAD) pathways to manage metabolic, inflammatory, and degenerative disorders, including Parkinson's disease, acne vulgaris, acute kidney injury, and acute respiratory distress syndrome.

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT07782671 NOT_YET_RECRUITING
Peripheral Artery Disease (PAD)
Northwestern University
 2026-12 PHASE3
NCT07741071 RECRUITING
Alzheimer Disease (AD)
Haukeland University Hospital
 2026-08-26 PHASE2
NCT06853743 RECRUITING
Huntington Disease
Oslo University Hospital
 2025-03-18 PHASE2
NCT06162013 RECRUITING
Progressive Supranuclear Palsy; Multiple System Atrophy; Corticobasal Syndrome
Haukeland University Hospital
 2024-03-05 PHASE2
NCT07739290 NOT_YET_RECRUITING
Acute Kidney Injury
Beth Israel Deaconess Medical Center
 2026-09-01
NCT07013591 RECRUITING
Coronary Artery Bypass Graft
Brigham and Women's Hospital
 2026-06-10 PHASE2
NCT07693543 NOT_YET_RECRUITING
Chronic Kidney Disease
University of California, San Diego
 2026-10-01 PHASE2
NCT06032923 RECRUITING
Systemic Lupus Erythematosus (Sle)
National Heart, Lung, and Blood Institute (NHLBI)
 2024-03-13 PHASE1; PHASE2
NCT07258667 NOT_YET_RECRUITING
Leber Hereditary Optic Neuropathy (LHON); Leber's Hereditary Optic Neuropathy (LHON); Mitochondrial Disease; Optic Nerve Disease
University Hospital, Angers
 2026-04 PHASE1
NCT06208527 RECRUITING
Frailty; Frail Elderly Syndrome; Frailty Syndrome; Aging
Haukeland University Hospital
 2025-01 PHASE2
NCT06488625 RECRUITING
Ulcerative Colitis, Unspecified
University Hospital Schleswig-Holstein
 2024-09-12 PHASE2; PHASE3
NCT07649161 RECRUITING
Healthy Adult
Massachusetts General Hospital
 2026-06
NCT06627868 RECRUITING
Obesity, Abdominal
University of Turku
 2024-11-20
NCT07572825 RECRUITING
DHDDS-Congenital Disorder of Glycosylation; DHDDS-CDG; Congenital Disorder of Glycosylation
Eva Morava-Kozicz
 2026-05-08 PHASE1
NCT05695027 ACTIVE_NOT_RECRUITING
Primary Open Angle Glaucoma
Columbia University
 2023-03-14 PHASE2; PHASE3
NCT07703137 ENROLLING_BY_INVITATION
Parkinson's Disease
University of Oklahoma
 2026-08-10
NCT07344636 RECRUITING
Health Adult Subjects
ZHANG Jiaqi
 2026-01-06
NCT06731582 ENROLLING_BY_INVITATION
Glaucoma
Singapore Eye Research Institute
 2024-03-12 PHASE3
NCT05483465 RECRUITING
Aging
University of Oklahoma
 2023-05-03 PHASE4
NCT04913805 RECRUITING
Heart Failure With Preserved Ejection Fraction
University of Pennsylvania
 2021-10-11 PHASE2
NCT07563322 RECRUITING
Pulmonary Hypertension
Vanderbilt University Medical Center
 2026-04-09
NCT05405868 RECRUITING
Glaucoma, Open-Angle
University College, London
 2024-01-18 PHASE3
NCT07692633 NOT_YET_RECRUITING
NAD+ Bioavailability; NAD+ Safety; NAD+ Efficacy
Reus Research
 2026-08
NCT06044935 RECRUITING
Overweight; Obesity
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
 2024-01-08
NCT06567717 RECRUITING
Idiopathic Pulmonary Fibrosis
Cedars-Sinai Medical Center
 2025-11-03 PHASE2
NCT07073352 RECRUITING
Adverse Childhood Experiences; Endothelial Dysfunction
University of Wisconsin, Madison
 2025-03-27
NCT07006194 NOT_YET_RECRUITING
Glaucoma
Università degli Studi 'G. d'Annunzio' Chieti e Pescara
 2025-10-01
NCT07144527 RECRUITING
Aging; Frailty; Exercise Tolerance; Healthy Male and Female Subjects
Scott Silveira
 2026-02-21
NCT07475208 NOT_YET_RECRUITING
Hypertension (HTN)
ZHANG Jiaqi
 2026-04
NCT05590468 ACTIVE_NOT_RECRUITING
Mitochondrial Myopathy
Ralitza Gavrilova
 2023-05-26 PHASE2
NCT04562831 ACTIVE_NOT_RECRUITING
Amyotrophic Lateral Sclerosis
Haukeland University Hospital
 2020-10-07
NCT04055818 RECRUITING
Sickle Cell Disease
EpiDestiny, Inc.
 2020-01-24 PHASE1
NCT06345443 ENROLLING_BY_INVITATION
Vascular Stiffness
Mayo Clinic
 2024-11-25
NCT05023993 ACTIVE_NOT_RECRUITING
Hematopoietic and Lymphoid Cell Neoplasm; Malignant Solid Neoplasm; Prediabetes
City of Hope Medical Center
 2022-06-23
NCT04844528 RECRUITING
Chronic Lymphocytic Leukemia; Non-melanoma Skin Cancer (NMSC)
University of Utah
 2022-02-25 PHASE2
NCT05561738 TERMINATED
Ulcerative Colitis
University of Pittsburgh
 2024-02-28
NCT05194397 RECRUITING
Lymphoblastic Leukemia; Cancer Survivors; Aplastic Anemia; Myelodysplastic Syndromes; Myeloid Leukemia
Children's Hospital of Philadelphia
 2023-02-23 PHASE2
NCT06971224 RECRUITING
Sleep
Haukeland University Hospital
 2025-10-13 PHASE2
NCT07428889 COMPLETED
Healthy Adult
Shaklee Corporation
 2026-02-17
NCT06950736 NOT_YET_RECRUITING
Infertility Female
The First Affiliated Hospital of Zhengzhou University
 2025-05-05
NCT04691986 ACTIVE_NOT_RECRUITING
Sarcopenia; Nicotinamide Adenine Dinucleotide Concentration; Muscle Quality and NAD+ Content
VA Office of Research and Development
 2023-09-01
NCT06426355 RECRUITING
Diminished Ovarian Reserve
Peking University Third Hospital
 2023-10-01
NCT06991712 RECRUITING
Glaucoma
Christopher Kai Shun Leung
 2025-05-19 PHASE2
NCT05095571 RECRUITING
Amyotrophic Lateral Sclerosis
Haukeland University Hospital
 2021-10-07
NCT06776510 RECRUITING
Immune Thrombocytopenia; Treatment
Institute of Hematology & Blood Diseases Hospital, China
 2025-01-15 PHASE1; PHASE2
NCT06324877 UNKNOWN
Ataxia Telangiectasia
The University of Queensland
 2024-05-01
NCT04589546 ACTIVE_NOT_RECRUITING
Acute Kidney Injury; Septic Shock; Nicotinamide; Mortality
Centre Hospitalier Universitaire, Amiens
 2020-10-01 PHASE3
NCT06333236 COMPLETED
Glaucoma
ASST Santi Paolo e Carlo
 2025-04-10
NCT05878119 COMPLETED
Healthy
Metro International Biotech, LLC
 2023-10-25 PHASE2
NCT05617508 COMPLETED
Alzheimer Disease; Dementia
Haukeland University Hospital
 2022-11-22 PHASE2
NCT03821623 RECRUITING
Hypertension; Aging
Douglas Seals
 2019-05-10 PHASE2
NCT06640309 RECRUITING
Rheumatoid Arthritis
Ain Shams University
 2023-12-02 PHASE2
NCT07156929 COMPLETED
Respiratory Infection (for Example, Pneumonia, Bronchitis); Respiratory Infection Virus; Community Acquired Pneumonia (CAP); COPD Acute Exacerbation; Inflammatory Bowel Disease (IBD)
University Hospital Schleswig-Holstein
 2024-04-20
NCT06919328 RECRUITING
Healthy Aging
Nutraceuticals Research Institute
 2024-10-31
NCT05243290 RECRUITING
Gulf War Illness
Roskamp Institute Inc.
 2022-04-13
NCT05589766 COMPLETED
Parkinson Disease
Haukeland University Hospital
 2023-01-23 PHASE2
NCT06214468 COMPLETED
Drug Toxicity
University of South Alabama
 2024-01-15 PHASE1
NCT04571008 COMPLETED
Glucose Metabolism Disorders
Washington University School of Medicine
 2020-10-01
NCT07022938 COMPLETED
Cancer; Neuropathy; Chemotherapy Induced Pain Neuropathy; Chemotherapy-Induced Peripheral Neuropathy
Aristotle University Of Thessaloniki
 2021-11-01 PHASE4
NCT05485610 UNKNOWN
Diminished Ovarian Reserve; Premature Ovarian Insufficiency
Peking University Third Hospital
 2022-07-01
NCT06465602 UNKNOWN
Frailty; Fall; Frailty Syndrome; Falls
University of Chile
 2024-05-21 PHASE2
NCT07049068 COMPLETED
Actinic Keratoses
Federal University of Rio Grande do Sul
 2022-02-01 PHASE1
NCT05703074 COMPLETED
Long COVID
University Hospital, Akershus
 2023-01-30 PHASE2
NCT04631484 COMPLETED
Head Trauma,Closed
POLYSAN Scientific & Technological Pharmaceutical Company
 2020-11-22 PHASE3
NCT06036355 UNKNOWN
Postoperative Prevention of Tumor
Shanghai Cell Therapy Group Co.,Ltd
 2023-09-30 EARLY_PHASE1
NCT06078605 UNKNOWN
Glaucoma
CHA University
 2022-09-16
NCT04342975 COMPLETED
AKI
Mayo Clinic
 2020-12-01 PHASE2
NCT05984550 UNKNOWN
Enhance Immune Function
Shanghai Cell Therapy Group Co.,Ltd
 2023-08 EARLY_PHASE1
NCT06280482 Recruiting
Smooth Muscle Dysfunction Syndrome (SMDS)
The University of Texas Health Science Center Houston
 2024-03-06 Phase 1
NCT04670081 COMPLETED
Treatment-resistant Depression
Central Institute of Mental Health, Mannheim
 2021-06-10 PHASE2
NCT05513807 COMPLETED
Delayed Graft Function
Assistance Publique - Hôpitaux de Paris
 2023-01-12 PHASE3
NCT05938036 Not yet recruiting
Acute Respiratory Distress Syndrome (ARDS)
Aqualung Therapeutics Corp.
 2024-01-14 Phase 2
NCT03769285 UNKNOWN
Non-melanoma Skin Cancer; Carcinoma, Squamous Cell; Carcinoma, Basal Cell
Women's College Hospital
 2018-12-03 PHASE2
NCT04994561 WITHDRAWN
Aging
Vitality in Aging Research Group, Inc.
 2022-06 PHASE1
NCT06249581 Active not recruiting
Chronic Stable Angina
Auxilius Pharma sp.z.o.o.
 2023-11-27 Early Phase 1
NCT04809974 COMPLETED
Covid19; Sequelae of; Infection; Cognitive Symptom
Massachusetts General Hospital
 2021-08-28 PHASE4
NCT06036355 Not yet recruiting
Postoperative Prevention of Tumor
Shanghai Cell Therapy Group Co.Ltd
 2023-09-30 Early Phase 1
NCT04112043 COMPLETED
Hypertension
University of Florida
 2020-07-28 PHASE1
NCT05696938 COMPLETED
Skin Darken
Shenzhen Precision Health Food Technology Co. Ltd.,
 2023-02-16
NCT05790577 COMPLETED
Melasma
Ishtiaq Ahmed
 2022-02-01 PHASE2
NCT04604704 COMPLETED
Covid19; Long COVID-19; Post-COVID-19 Syndrome
AgelessRx
 2021-01-28 PHASE2
NCT04271735 COMPLETED
Psoriasis; Atherosclerotic Cardiovascular Disease; Obesity; Dyslipidemia; Cardiometabolic Diseases
National Heart, Lung, and Blood Institute (NHLBI)
 2020-08-26
NCT04110028 COMPLETED
Inflammation; Acute Illness
Oslo University Hospital
 2019-10-01 PHASE1; PHASE2
NCT05517122 COMPLETED
Healthy
Société des Produits Nestlé (SPN)
 2022-07-12
NCT04078178 COMPLETED
Cognition Disorders in Old Age; Mild Cognitive Impairment; Cognitive Decline
Steven E Arnold, MD
 2020-10-30
NCT04012177 UNKNOWN
Undernutrition
Vital Pakistan Trust
 2019-07-22
NCT04910061 COMPLETED
Healthy Volunteers
Seneque SA
 2021-08-05
NCT03061474 COMPLETED
Alzheimer's Disease; Mild Cognitive Impairment
University of California, Irvine
 2017-07-12 PHASE2
NCT04990869 COMPLETED
COPD
University of Copenhagen
 2021-08-05
NCT05175768 TERMINATED
COVID-19 Infection
Vedic Lifesciences Pvt. Ltd.
 2021-12-27
NCT04903210 UNKNOWN
Hypertension
First Affiliated Hospital, Sun Yat-Sen University
 2021-06-01 PHASE4
NCT04874662 COMPLETED
Muscle Injury
Société des Produits Nestlé (SPN)
 2021-05-03
NCT03685253 TERMINATED
Diabetic Neuropathy Peripheral
University of Maryland, Baltimore
 2019-01-24 PHASE1; PHASE2
NCT05916066 COMPLETED
Glaucoma
Umeå University
 2021-10-16
NCT05258474 COMPLETED
Safety Issues; Pharmacokinetic
University Hospital Schleswig-Holstein
 2020-12-04 PHASE1
NCT04818216 COMPLETED
SARS-CoV-2 Infection; Acute Kidney Injury
The University of Texas Health Science Center at San Antonio
 2021-06-11 PHASE2
NCT04823260 COMPLETED
Aging
Abinopharm, Inc
 2021-05-25
NCT04862338 COMPLETED
Healthy Volunteers
Seneque SA
 2021-04-26
NCT03579693 COMPLETED
Chronic Kidney Disease; Sarcopenia; Frailty
University of Washington
 2018-11-14 PHASE2
NCT07062120 COMPLETED
Melasma
Second Affiliated Hospital of Xi'an Jiaotong University
 2021-01-01
NCT03635411 UNKNOWN
Recovery of Function
Elysium Health
 2018-12-06 PHASE1
NCT04538521 COMPLETED
Mitochondrial Myopathies
University of Helsinki
 2019-02-11
NCT04910230 COMPLETED
Covid19; Lymphopenia
Qiang Hu
 2020-03-01
NCT03418935 COMPLETED
Jaundice, Obstructive
POLYSAN Scientific & Technological Pharmaceutical Company
 2017-04-03 PHASE3
NCT02416739 UNKNOWN
Non-Small-Cell Lung Carcinoma
Il Yeong Park, Ph.D.
 2015-03 PHASE2; PHASE3
NCT03268902 COMPLETED
Malnutrition; Stunting; Cognitive Development; Enteric Pathogens
Haydom Lutheran Hospital
 2017-09-05 PHASE2; PHASE3
NCT03816020 COMPLETED
Parkinson Disease; Neurodegenerative Diseases
Haukeland University Hospital
 2019-03-09
NCT03260166 UNKNOWN
Cutaneous Lupus Erythematosus; Systemic Lupus Erythematosus Rash
Second Xiangya Hospital of Central South University
 2017-08-31 PHASE2
NCT03501433 COMPLETED
Aging; Lipemia
Iowa State University
 2018-02-01
NCT03962114 COMPLETED
Ataxia Telangiectasia; ATM Gene Mutation
Radboud University Medical Center
 2019-03-18 PHASE2
NCT03565328 TERMINATED
Heart Failure
National Heart, Lung, and Blood Institute (NHLBI)
 2018-09-27 PHASE2
NCT03789175 COMPLETED
Cancer; Skin Fibroblasts; Muscle Weakness
National Heart, Lung, and Blood Institute (NHLBI)
 2019-03-25 PHASE1; PHASE2
NCT02942888 COMPLETED
Mild Cognitive Impairment; NAD
The University of Texas Health Science Center at San Antonio
 2017-11-30
NCT03423342 COMPLETED
Heart Failure, Systolic
University of Washington
 2016-05-19 PHASE1; PHASE2
NCT04843553 COMPLETED
Actinic Keratoses
Rhode Island Hospital
 2016-10-14 EARLY_PHASE1
NCT02835664 COMPLETED
Obesity; Insulin Resistance
Maastricht University Medical Center
 2016-12
NCT03727646 COMPLETED
Heart Failure，Congestive; Heart Failure New York Heart Association Class IV; Mitochondrial Alteration
University of Washington
 2018-09-26 EARLY_PHASE1
NCT02258074 COMPLETED
Chronic Kidney Disease
The Cleveland Clinic
 2015-03 PHASE2
NCT03176628 COMPLETED
Acute Kidney Injury
Massachusetts General Hospital
 2017-11-01
NCT02950441 UNKNOWN
Aging
University of Birmingham
 2016-06 PHASE2
NCT02812238 COMPLETED
Atherosclerosis; Diabetes; Coronary Artery Disease
National Heart, Lung, and Blood Institute (NHLBI)
 2016-06-23
NCT03136705 COMPLETED
Healthy
Northwestern University
 2016-02-03 PHASE1
NCT02838472 UNKNOWN
Glucocorticoids Deficiency
Hadassah Medical Organization
 2016-06
NCT02303483 COMPLETED
Obese
Aarhus University Hospital
 2016-01-04
NCT02712593 COMPLETED
Bioavailability
KGK Science Inc.
 2016-03-21 PHASE2
NCT03626298 COMPLETED
Acne Vulgaris
Rumah Sakit Pusat Angkatan Darat Gatot Soebroto
 2016-08-01 PHASE4
NCT02758990 TERMINATED
Obesity; Rhinitis; Rhinitis, Allergic; Respiratory Sounds; Dyspnea; Headache; Migraine Disorders; Arthritis; Arthralgia; Anxiety; Sleep Initiation and Maintenance Disorders; Sleep Deprivation
Verifomics LLC
 2016-03
NCT02921659 COMPLETED
Aging
University of Colorado, Boulder
 2015-04 PHASE1; PHASE2
NCT02213094 COMPLETED
Pregnancy Induced Hypertension; Superimposed Preeclampsia; Hypertension
University of North Carolina, Chapel Hill
 2014-01-01 PHASE1
NCT02689882 COMPLETED
Metabolic Disturbance
University of Washington
 2015-11 PHASE1
NCT01589809 UNKNOWN
Neurodegenerative Disorders
Imperial College London
 2012-06 PHASE2
NCT00580931 COMPLETED
Alzheimer's Disease
University of California, Irvine
 2008-01 PHASE1; PHASE2
NCT01011699 TERMINATED
Chronic Renal Failure; Hemodialysis
Centre Hospitalier Universitaire, Amiens
 2010-01 PHASE3
NCT01763424 COMPLETED
Psoriasis
Isfahan University of Medical Sciences
 2011-07 PHASE2; PHASE3
NCT01085981 UNKNOWN
Female Sexual Dysfunction
East Suburban Ob Gyn
 2010-04

(data from https://clinicaltrials.gov, updated on 2026-08-24)

Check the Nicotinamide (Niacinamide) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Compliance for Clinical Use

Mechanism and Biochemical Profile

Nicotinamide directly binds to and inhibits class III histone deacetylases (sirtuins), thereby preventing the deacetylation of key target proteins and altering cellular metabolism and stress response pathways. By regulating cellular energy homeostasis and inflammatory cascades, this compound demonstrates therapeutic relevance in attenuating neurodegenerative pathology in Parkinson's disease and suppressing cutaneous inflammatory responses in acne vulgaris.

Appendix RUO and cGMP Quality Standards

Quality Dimension RUO (Research Use Only) cGMP (Current Good Manufacturing Practice)
Clinical Applicability Prohibited in human clinical trials or medical diagnostics. Mandatory for human clinical trials (Phase I–III) and therapies.
Regulatory Status Non-regulated grade; exempt from drug manufacturing laws. Legally enforced by health authorities (e.g., FDA, EMA, NMPA).
Facility Environment Unclassified analytical or research laboratories. Validated Cleanrooms (ISO Class 5–8) with continuous monitoring.
Quality Control Basic purity and activity testing. Rigorous safety release testing (Sterility, Endotoxin, Mycoplasma).
Process Validation Basic equipment calibration; no process validation required. Full qualification (IQ/OQ/PQ) and complete batch records.
Quality Assurance Vendor self-declared without required formal QMS. Mandatory QA/QC unit, Change Control, CAPA, and vendor audits.
Regulatory Impact High risk of IND rejection if used as a critical raw material. Required for IND/NDA filings, supported by Drug Master Files (DMF).

Footnotes

Regulatory Note: Governed by FDA (21 CFR Parts 210/211/312), EMA (EudraLex Vol 4), ICH Guidelines (E6/Q7/Q9/Q10), and compendial standards (USP <71>/<85>/<1043>).

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Note: Technical data last updated: Sep 1, 2026.