Nedisertib (M3814): Selectivity & Specificity
Nedisertib (M3814) is a potent inhibitor of DNA-PK (subnanomolar), PRKDC (43 nM), ATM (>30,000 nM), ATR (>30,000 nM), MTOR (550 nM), PIK3CA (800 nM), PIK3CB (170 nM), PIK3CG (1590 nM), PIK3CD (350 nM), PI3Kalpha –delta. Nedisertib (M3814) exhibits the greatest inhibitory potency toward PRKDC (IC50 = 43 nM).