CAS No. 474645-27-7

Batch: Purity:99.99
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MMAE (Monomethyl auristatin E) Chemical Structure
Chemical Structure
Check the MMAE (Monomethyl auristatin E) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (2S)-N-[(2S)-1-[[(3R,4S,5S)-1-[(2S)-2-[(1R,2R)-3-[[(1S,2R)-1-hydroxy-1-phenylpropan-2-yl]amino]-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl]-3-methoxy-5-methyl-1-oxoheptan-4-yl]-methylamino]-3-methyl-1-oxobutan-2-yl]-3-methyl-2-(methylamino)butanamide
CAS Number 474645-27-7
Molecular Formula
C39H67N5O7
 
Molecular Weight (MW) 717.98
SMILES CCC(C)C(C(CC(=O)N1CCCC1C(C(C)C(=O)NC(C)C(C2=CC=CC=C2)O)OC)OC)N(C)C(=O)C(C(C)C)NC(=O)C(C(C)C)NC
InChIKey DASWEROEPLKSEI-UIJRFTGLSA-N

Ordering Information

Biological Activity

MMAE (Monomethyl auristatin E) is a synthetic antineoplastic agent that acts as a potent tubulin inhibitor and microtubule-disrupting agent. By binding to tubulin, MMAE inhibits tubulin polymerization and disrupts microtubule dynamics within the mitotic spindle. This inhibition impairs cellular division, triggering G2/M phase cell cycle arrest and subsequently inducing apoptotic cell death in target cancer cells. [1]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (139.27 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 100 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.