CAS No. 783348-36-7
Batch:
Purity:99.99
Chemical Structure
Check the
MLN120B
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N-(6-chloro-7-methoxy-9H-pyrido[3,4-b]indol-8-yl)-2-methylpyridine-3-carboxamide | |
|---|---|---|
| CAS Number | 783348-36-7 | |
| Molecular Formula |
C19H15ClN4O2 |
|
| Molecular Weight (MW) | 366.80 | |
| SMILES | COC1=C(NC(=O)C2=CC=CN=C2C)C3=C(C=C1Cl)C4=C([NH]3)C=NC=C4 | |
| InChIKey | ZNOLRTPMNMPLHY-UHFFFAOYSA-N |
MLN120B is a potent, selective, and ATP-competitive inhibitor of IKKβ. By blocking IKKβ activity, MLN120B prevents the phosphorylation and degradation of IκBα, thereby suppressing downstream NF-κB pathway activation and nuclear translocation. This inhibition leads to the downregulation of anti-apoptotic proteins, suppression of pro-inflammatory cytokine secretion, and inhibition of cell proliferation in multiple myeloma cells. [1]
|
Concentration
Volume
Mass
|
1 mg | 5 mg | 10 mg |
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
73 mg/mL
(199.01 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 5 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.