CAS No. 1032350-13-2
Batch:
Purity:99.98
Chemical Structure
Check the
MK-2206 Dihydrochloride
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 8-[4-(1-aminocyclobutyl)phenyl]-9-phenyl-2H-[1,2,4]triazolo[3,4-f][1,6]naphthyridin-3-one;dihydrochloride | |
|---|---|---|
| CAS Number | 1032350-13-2 | |
| Molecular Formula |
C25H21N5O.2HCl |
|
| Molecular Weight (MW) | 480.39 | |
| SMILES | C1CC(C1)(C2=CC=C(C=C2)C3=C(C=C4C(=N3)C=CN5C4=NNC5=O)C6=CC=CC=C6)N.Cl.Cl | |
| InChIKey | HWUHTJIKQZZBRA-UHFFFAOYSA-N |
MK-2206 dihydrochloride is a selective, allosteric Akt inhibitor targeting Akt1, Akt2, and Akt3. By blocking Akt phosphorylation, MK-2206 disrupts downstream AKT pathway signaling, resulting in the inhibition of cancer cell proliferation, induction of autophagy, and promotion of apoptosis. Additionally, it acts synergistically with targeted and chemotherapeutic agents to enhance antitumor efficacy across various tumor models. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
96 mg/mL
(199.83 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 96 mg/mL |
| Ethanol | Insoluble |
| DMSO |
30 mg/mL
(62.44 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
96 mg/mL
(199.83 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
25 mg/mL
(52.04 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 2 mg/mL |
| Ethanol | Insoluble |
| DMSO |
96 mg/mL
(199.83 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 10 mg/mL |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- MK-2206 Dihydrochloride Mechanism of Action: AKT Inhibition in Tumor Cell Research
- MK-2206 Dihydrochloride Clinical Trials
- MK-2206 Dihydrochloride: Selectivity & Specificity
- MK-2206 Dihydrochloride Working Concentration | Cell Culture | Treatment
- MK-2206 Dihydrochloride Solubility in DMSO
- MK-2206 Dihydrochloride Stock Solution
- MK-2206 Dihydrochloride Storage
- MK-2206 Dihydrochloride Stability
- MK-2206 Dihydrochloride Combination Database
- MK-2206 Dihydrochloride Molecular Weight
- MK-2206 Dihydrochloride SMILES
- MK-2206 Dihydrochloride Chemical Structure (2D and 3D)
- MK-2206 Dihydrochloride IC50 for Cell-based and Cell-free Assays
- MK-2206 Dihydrochloride Sigma (AMBH2D6FB186)? Try a better option.
- MK-2206 Dihydrochloride MedChemExpress (HY-10358)? Try a better option.
- MK-2206 Dihydrochloride Cayman (11593)? Try a better option.
- MK-2206 Dihydrochloride Tocris (7850)? Try a better option.
- MK-2206 Dihydrochloride Abmole (M1837)? Try a better option.
- MK-2206 Dihydrochloride SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.