CAS No. 120685-11-2
Batch:
Purity:99.98
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Chemical Structure
Check the
Midostaurin (PKC412)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N-[(2S,3R,4R,6R)-3-methoxy-2-methyl-16-oxo-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8,10,12,14,19,21,23,25,27-nonaen-4-yl]-N-methylbenzamide | |
|---|---|---|
| CAS Number | 120685-11-2 | |
| Molecular Formula |
C35H30N4O4 |
|
| Molecular Weight (MW) | 570.64 | |
| SMILES | CC12C(C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)N(C)C(=O)C9=CC=CC=C9)OC | |
| InChIKey | BMGQWWVMWDBQGC-IIFHNQTCSA-N |
Midostaurin (PKC412) is a broad-spectrum, multi-targeted kinase inhibitor active against FLT3, c-Kit, PKC isoforms, PDGFRβ, and VEGFR1/2 with IC50 values ranging from 80 to. By inhibiting these kinases, it suppresses receptor autophosphorylation and disrupts downstream STAT5, AKT, and MAPK signaling pathways. This inhibition results in G1 phase cell cycle arrest and induces apoptosis in FLT3-mutated leukemia cell lines. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(175.24 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 2 mg/mL |
| Water | Insoluble |
| DMSO |
100 mg/mL
(175.24 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 100 mg/mL |
| Water | Insoluble |
| DMSO |
100 mg/mL
(175.24 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 32 mg/mL |
| Water | Insoluble |
| DMSO |
100 mg/mL
(175.24 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 20 mg/mL |
| Water | Insoluble |
| DMSO |
100 mg/mL
(175.24 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 39 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- Midostaurin (PKC412) Mechanism of Action: FLT3 Inhibition in Leukemic Blast Cells Research
- Midostaurin (PKC412) Clinical Trials
- Midostaurin (PKC412) Solubility in DMSO
- Midostaurin (PKC412) Stock Solution
- Midostaurin (PKC412) Storage
- Midostaurin (PKC412) Stability
- Midostaurin (PKC412) Molecular Weight
- Midostaurin (PKC412) SMILES
- Midostaurin (PKC412) Chemical Structure (2D and 3D)
- Midostaurin (PKC412) Sigma (569397)? Try a better option.
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- Midostaurin (PKC412) Cayman (10459)? Try a better option.
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- Midostaurin (PKC412) SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.