MCC950 is a potent, highly selective NLRP3 inflammasome inhibitor. It affects NLRP3 and IL-1β signaling by binding to the NACHT domain to block ATP hydrolysis and oligomerization, effectively inhibiting inflammasome activation and subsequent inflammatory responses.
MCC950: Mechanism of Action
MCC950 MOA：Targeting NLRP3/Inflammasome Pathway for Neuroinflammation and Neurodegenerative Diseases