MCC950 is a potent, highly selective NLRP3 inflammasome inhibitor. It affects NLRP3 and IL-1β signaling by binding to the NACHT domain to block ATP hydrolysis and oligomerization, effectively inhibiting inflammasome activation and subsequent inflammatory responses.
MCC950 IC50 for Cell-based and Cell-free Assays
Comprehensive IC50 Values for MCC950 Across Cell-free Enzyme Inhibitory Profiles and Cell-based Functional Assays.