Levofloxacin Clinical Trials

Size	Price	Qty
25mg	USD 147
100mg	USD 247

Clinical Trials

Numerous clinical trials, spanning Early Phase 1 through Phase 4, evaluate the therapeutic efficacy of levofloxacin across diverse indications. Sponsored by pharmaceutical corporations such as Sanofi and GlaxoSmithKline alongside academic centers like Shandong University and The First Hospital of Jilin University, research targets infectious diseases—including Helicobacter pylori, pneumonia, prostatitis, and resistant bacterial strains—and non-infectious conditions like acute ischemic stroke and cataract management. Across these studies, recruitment statuses vary from active recruitment and completion to withdrawal or termination.

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT07675954	NOT_YET_RECRUITING	Rifampicin-Resistant Tuberculosis	Seoul National University Hospital	2026-10-01	PHASE3
NCT06810583	RECRUITING	Leukemia; Acute Myeloid Leukemia; Lymphoblastic Leukemia in Children	St. Jude Children's Research Hospital	2025-05-22	PHASE1
NCT07585461	NOT_YET_RECRUITING	Opportunistic Infections, HIV Related; Disseminated Mycobacterium Avium Complex Infection	Shanghai Public Health Clinical Center	2026-04-30
NCT07788404	RECRUITING	Prosthetic Joint Infection; Osteomyelitis; Staphylococcal Infections	Groupe Hospitalier Diaconesses Croix Saint-Simon	2023-06-10
NCT06494072	RECRUITING	Community Acquired Pneumonia in Children	Medical College of Wisconsin	2024-08-22	PHASE4
NCT07528417	NOT_YET_RECRUITING	Myeldysplastic Syndrome (MDS); MYELOPROLIFERATIVE DISORDER (P Vera, CMML, ET); Acute Myeloid Leukemia	University of Manitoba	2026-09-01	PHASE2
NCT07240077	RECRUITING	Bacteremia; Streptococcus Infection	Mahidol University	2026-01-08	PHASE4
NCT07624422	NOT_YET_RECRUITING	Helicobacter Pylori Infection; Peptic Ulcer Disease; Gastritis	Damascus Hospital	2026-11-01	PHASE4
NCT07779629	NOT_YET_RECRUITING	Brucellosis; Osteoarthritis	The First Affiliated Hospital of Shihezi University	2026-09-01
NCT07126639	NOT_YET_RECRUITING	Efficacy and Safety	Wuhan Pulmonary Hospital	2025-09-01
NCT07198685	NOT_YET_RECRUITING	Treat to Target; Treatment Duration	Wuhan Pulmonary Hospital	2025-09-30
NCT06568484	RECRUITING	Tuberculosis, Latent	Johns Hopkins University	2026-05-08	PHASE2; PHASE3
NCT03828201	ACTIVE_NOT_RECRUITING	Tuberculosis, Multidrug-Resistant	Boston University	2022-06-07	PHASE2
NCT06498414	RECRUITING	Tuberculosis Infection, Latent	McGill University Health Centre/Research Institute of the McGill University Health Centre	2025-06-10	PHASE2; PHASE3
NCT06172010	RECRUITING	Prosthetic-joint Infection; Infection Hip; Infection; Knee, Joint	Leiden University Medical Center	2023-04-01	PHASE4
NCT06649721	ACTIVE_NOT_RECRUITING	Drug-resistant Tuberculosis; Pulmonary Tuberculosis; Rifampin-resistant Tuberculosis	Huashan Hospital	2024-11-27	PHASE3
NCT06065267	NOT_YET_RECRUITING	Helicobacter Pylori Infection	Damascus Hospital	2024-01-02	PHASE4
NCT06977347	NOT_YET_RECRUITING	Severe Community-acquired Pneumonia (sCAP)	CHOSEOK YOON	2025-06-15
NCT05398679	RECRUITING	Endocarditis Infective	Fundacion Clinic per a la Recerca Biomédica	2022-08-17	PHASE4
NCT07696819	NOT_YET_RECRUITING	Surgical Site Infection (SSI)	Sylhet M.A.G.Osmani Medical College	2026-08-01
NCT07069582	NOT_YET_RECRUITING	Tuberculosis Infection; Healthy Volunteer; Breastfeeding	McGill University Health Centre/Research Institute of the McGill University Health Centre	2026-04-01	PHASE1
NCT07574983	NOT_YET_RECRUITING	HELICOBACTER PYLORI INFECTIONS	University of Health Sciences Lahore	2026-06-01
NCT06081361	ACTIVE_NOT_RECRUITING	Pulmonary Tuberculosis; Rifampicin-resistant Tuberculosis	Beijing Chest Hospital	2023-12-22	PHASE3
NCT06200779	NOT_YET_RECRUITING	Helicobacter Pylori Infection	Manuel Coelho da Rocha	2025-09	PHASE4
NCT07179159	RECRUITING	HELICOBACTER PYLORI INFECTIONS	Yanqing Li	2025-09-09
NCT07320534	NOT_YET_RECRUITING	Neutropenic Fever; Acute Lymphoblastic Leukemia	Gadjah Mada University	2026-01-01	PHASE4
NCT06741917	UNKNOWN	Retrograde Intrarenal Surgery; Renal Stones	National Taiwan University Hospital	2024-12-04	PHASE4
NCT05061732	UNKNOWN	Helicobacter Pylori Infection	Shanghai Zhongshan Hospital	2021-09-30	PHASE4
NCT06209047	RECRUITING	Bronchiectasis With Acute Exacerbation	Assiut University	2023-10-15	PHASE4
NCT06787885	COMPLETED	Empyema, Pleural	Fayoum University	2024-05-01
NCT07344506	RECRUITING	H. Pylori Gastrointestinal Disease; H.Pylori Infection; H.Pylori Eradication Rate	Dow University of Health Sciences	2025-05-01	PHASE4
NCT05743101	UNKNOWN	Acute Ischemic Stroke	Yi Yang	2025-05-01
NCT07021729	NOT_YET_RECRUITING	Helicobacter Pylori Infection	Rehman Medical Institute - RMI	2025-12	PHASE4
NCT02735707	RECRUITING	Community-acquired Pneumonia, Influenza, COVID-19	UMC Utrecht	2016-04-11	PHASE3
NCT07040839	NOT_YET_RECRUITING	H Pylori	Rehman Medical Institute - RMI	2025-07	PHASE4
NCT06049758	NOT_YET_RECRUITING	Blood Loss; Intensive Care; Anastomotic Leakage; Lymph Node Disease; Survival; Blood Transfusion	General Committee of Teaching Hospitals and Institutes, Egypt	2024-01-02
NCT04951986	ACTIVE_NOT_RECRUITING	Disseminated Tuberculosis; HIV	University of Cape Town	2021-08-11	PHASE3
NCT06797544	RECRUITING	Cutaneous Leishmaniasis	Hayder Adnan Fawzi	2025-02-09	PHASE2
NCT05867654	UNKNOWN	Osteomyelitis of Jaw	University of Louisville	2024-07-31	PHASE4
NCT06650540	NOT_YET_RECRUITING	IVF	Peking University Third Hospital	2024-10-22
NCT06859450	NOT_YET_RECRUITING	Community Acquired Pneumonia (CAP)	Copenhagen Respiratory Research	2025-03-04	PHASE2; PHASE3
NCT05306223	UNKNOWN	Tuberculosis, Multidrug-Resistant	Beijing Chest Hospital	2022-05-10	PHASE4
NCT07150065	COMPLETED	Typhoid; Fever	Avicenna Medical College Lahore	2025-02-07	PHASE2
NCT06915688	NOT_YET_RECRUITING	COPD	Amina Aslam	2025-04-15
NCT06571097	UNKNOWN	Constipation	Haifeng Lan	2024-07-01
NCT07150286	COMPLETED	Immune Thrombocytopenic Purpura; HELICOBACTER PYLORI INFECTIONS	Al-Mustansiriyah University	2024-09-01
NCT05393505	UNKNOWN	Neutropenic Fever	The University of Hong Kong	2022-10-24	PHASE4
NCT04502095	COMPLETED	Bladder Carcinoma; Refractory Bladder Carcinoma; Urinary Tract Infection	Roswell Park Cancer Institute	2020-09-02	PHASE4
NCT05977868	TERMINATED	Endovascular Infection; Bone and Joint Infection; Skin and Soft Tissue Infection; Pulmonary Infection; Gastrointestinal Infection; Genitourinary Infection	West Virginia University	2023-08-04	PHASE4
NCT05741905	RECRUITING	Acute Ischemic Stroke	Yi Yang	2023-06-01
NCT07229755	COMPLETED	Urinary Tract Infection (Diagnosis)	Ain Shams University	2024-07-01	PHASE2; PHASE3
NCT05850117	UNKNOWN	Helicobacter Pylori Eradication	Kaohsiung Medical University	2020-02-10
NCT05799326	RECRUITING	Acute Ischemic Stroke	Yi Yang	2023-06-30
NCT05302531	UNKNOWN	Short Bowel Syndrome; Infection, Bacterial	Central Hospital, Nancy, France	2022-12-09	PHASE1
NCT06351891	UNKNOWN	Helicobacter Pylori Infection	Qilu Hospital of Shandong University	2024-04	PHASE4
NCT05156437	TERMINATED	Endocarditis	West Virginia University	2022-03-16	PHASE4
NCT06710977	COMPLETED	Cataract	Tan Tock Seng Hospital	2022-01-01	EARLY_PHASE1
NCT03850379	COMPLETED	Prophylaxis; Stem Cell Transplant Complications	Henry Ford Health System	2018-03-14	PHASE2
NCT02701608	COMPLETED	Infective Endocarditis	University Hospital, Tours	2016-02-29	PHASE3
NCT06684626	COMPLETED	Prostate Inflammation; Prostate Disease; Chronic Bacterial Prostatitis	Federico II University	2024-03-01	PHASE3
NCT03594149	COMPLETED	Myelodysplastic Syndromes; Acute Myeloid Leukemia	Centre Henri Becquerel	2018-07-18	PHASE3
NCT07355907	COMPLETED	Calculi, Renal; PCNL; Infectious Complications	Tanta University	2023-01-01
NCT05575427	UNKNOWN	Hospital Infections	Mahidol University	2022-11-24	PHASE4
NCT04062201	COMPLETED	Tuberculosis; Pre-XDR-TB; Extensively Drug-Resistant Tuberculosis; Multi Drug Resistant Tuberculosis; Rifampicin Resistant Tuberculosis	Wits Health Consortium (Pty) Ltd	2019-08-22	PHASE3
NCT05079620	TERMINATED	Aspiration; Aspiration Pneumonia	UConn Health	2021-11-30	PHASE4
NCT06414707	COMPLETED	Helicobacter Pylori Infection	Ain Shams University	2023-10-12	PHASE3
NCT05743101	Not yet recruiting	Acute Ischemic Stroke	Yi Yang\|The First Hospital of Jilin University	2024-04-01	Not Applicable
NCT06017479	COMPLETED	Urological System Complication of Procedure; Urinary Tract Infections	Indonesia University	2022-12-30	PHASE1; PHASE2
NCT03087656	UNKNOWN	Cholangitis	University of Southern California	2017-03-29	PHASE4
NCT06088316	UNKNOWN	Helicobacter Pylori Infection; Helicobacter Pylori Eradication	Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh	2023-02-10	PHASE4
NCT05549115	UNKNOWN	Helicobacter Pylori Infection	Liaocheng People's Hospital	2022-09-20
NCT04626193	UNKNOWN	Helicobacter Pylori Infection	Damascus Hospital	2020-10-31	PHASE4
NCT05313750	UNKNOWN	Acute Exacerbation of Bronchiectasis	Shanghai Pulmonary Hospital, Shanghai, China	2021-06-30	PHASE4
NCT05441930	WITHDRAWN	Cataract	PolyActiva Pty Ltd	2023-06-23	PHASE1
NCT06616922	COMPLETED	Conjunctivitis, Bacterial	NTC srl	2021-11-05	PHASE2
NCT05799326	Recruiting	Acute Ischemic Stroke	Yi Yang\|The First Hospital of Jilin University	2023-06-30	Not Applicable
NCT05741905	Recruiting	Acute Ischemic Stroke	Yi Yang\|The First Hospital of Jilin University	2023-06-01	Not Applicable
NCT05441930	Withdrawn	Cataract	PolyActiva Pty Ltd	2023-06-23	Phase 1
NCT02754765	COMPLETED	Tuberculosis, Multidrug-Resistant; Infection, Bacterial; Pulmonary Tuberculoses	Médecins Sans Frontières, France	2016-12	PHASE3
NCT04359966	UNKNOWN	Helicobacter Pylori Infection; Eradication Treatments	Slovenian Society for Gastroenterology and Hepatology	2020-05-10
NCT06199778	TERMINATED	Traumatic Brain Injury	Zeng Changhao	2022-06-01
NCT05728424	UNKNOWN	Helicobacter Pylori Infection	Aga Khan University	2022-09-20	PHASE3
NCT05741632	COMPLETED	Cataract	Indonesia University	2023-02-01	PHASE1
NCT03257423	UNKNOWN	Acute Appendicitis	Turku University Hospital	2017-04-04
NCT05023577	UNKNOWN	Helicobacter Pylori Infection	Shanghai Zhongshan Hospital	2021-08-26	PHASE4
NCT05250050	WITHDRAWN	Helicobacter Pylori Infection	Shanghai Zhongshan Hospital	2022-03-25	PHASE4
NCT02621359	UNKNOWN	Dyspepsia	Tanta University	2015-01	PHASE3
NCT04122287	UNKNOWN	Helicobacter Pylori Infection	Shandong University	2019-11-01	PHASE4
NCT04204382	UNKNOWN	Radiation-induced Oral Mucositis	Shanxi Zhendong Pharmacy Co., Ltd	2019-12-12	PHASE4
NCT03098485	COMPLETED	Microbiota; Anti-bacterial Agents	Washington University School of Medicine	2017-01
NCT02981615	COMPLETED	Prevention	Sheba Medical Center	2017-08-01	PHASE3
NCT05129176	UNKNOWN	Helicobacter Pylori Infection	Shandong University	2021-11-23	PHASE4
NCT05126121	UNKNOWN	Helicobacter Pylori Infection	Xiuli Zuo	2021-11-20
NCT04991584	UNKNOWN	Helicobacter Pylori Infection	Shandong University	2021-08-04
NCT02409290	COMPLETED	MDR-TB	IUATLD, Inc	2016-03	PHASE3
NCT05219877	COMPLETED	Urinary Tract Infections	Indonesia University	2022-02-04	PHASE1; PHASE2
NCT01918397	COMPLETED	Tuberculosis, Multidrug-Resistant	Boston University	2015-01	PHASE2
NCT03474198	COMPLETED	Tuberculosis, Pulmonary	University College, London	2018-03-21	PHASE2; PHASE3
NCT04212078	UNKNOWN	Endophthalmitis Postoperative	National University of Malaysia	2019-07-29	PHASE1; PHASE2
NCT03021590	WITHDRAWN	Helicobacter Pylori Gastrointestinal Tract Infection	Damascus Hospital	2017-06-01	PHASE4
NCT03779074	COMPLETED	Helicobacter Pylori Infection	Kaohsiung Veterans General Hospital.	2018-09-03	PHASE3
NCT05863858	COMPLETED	Helicobacter Pylori Infection; Helicobacter Pylori Infection, Susceptibility to	Iyad Naeem Muhammad, PhD	2020-06-01	PHASE3
NCT04682288	COMPLETED	Cataract	PolyActiva Pty Ltd	2021-01-04	PHASE1
NCT03555526	UNKNOWN	H Pylori Infection	National Taiwan University Hospital	2017-12-15	PHASE4
NCT04374188	UNKNOWN	Nephrolithiasis	Diaa Eldin Taha Ramadan Mohamed	2019-09-01
NCT02975570	WITHDRAWN	Tuberculosis Multi Drug Resistant Active	Boston University	2017-08	PHASE3
NCT04212429	UNKNOWN	Endophthalmitis Postoperative	National University of Malaysia	2019-09-23	PHASE1; PHASE2
NCT04214821	UNKNOWN	Endophthalmitis	National University of Malaysia	2019-09-23	PHASE1; PHASE2
NCT02619994	COMPLETED	Tuberculosis, Multidrug-Resistant	Seoul National University Hospital	2016-01	PHASE2
NCT04432233	UNKNOWN	Helicobacter Pylori Infection; Intravenous Drug Usage	Shanghai Jiao Tong University School of Medicine	2020-06-15	PHASE4
NCT02809131	COMPLETED	Sick Sinus Syndrome; Complete Heart Block; Syncope; Chronic Systolic Heart Failure	Vanderbilt University Medical Center	2016-04-01	PHASE3
NCT04107194	UNKNOWN	Helicobacter Pylori Infection; Antibiotic Resistant Infection; Antibiotic Resistant Strain	University of Bari	2020-01-14	PHASE3
NCT03673956	COMPLETED	Chronic Rhinosinusitis (Diagnosis)	Mayo Clinic	2018-09-26	PHASE1; PHASE2
NCT03698682	COMPLETED	Chronic Obstructive Pulmonary Disease	University of Monastir	2018-01-01	PHASE2
NCT02454205	COMPLETED	Tuberculosis; Multidrug Resistant Tuberculosis; Extensively-drug Resistant Tuberculosis	University of Cape Town	2015-11-12	PHASE2; PHASE3
NCT02618057	UNKNOWN	Mycoplasma Pneumoniae Pneumonia	Seoul National University Hospital	2016-06	PHASE4
NCT02958709	COMPLETED	Tuberculosis, Meningeal	Johns Hopkins University	2017-02-22	PHASE1; PHASE2
NCT02717871	COMPLETED	Keratitis; Infectious Disease (Manifestation)	University Hospital, Geneva	2016-03	PHASE3
NCT04348786	COMPLETED	Helicobacter Pylori Infection	Damascus Hospital	2019-02-01	PHASE4
NCT03832465	COMPLETED	Helicobacter Pylori Infection	Mackay Memorial Hospital	2019-06-14	PHASE4
NCT03613389	UNKNOWN	Oral Mucositis (Ulcerative) Due to Antineoplastic Therapy	Cairo University	2020-01-01
NCT03201796	COMPLETED	Chronic Bacterial Prostatitis	Aziende Chimiche Riunite Angelini Francesco S.p.A	2016-02-02	PHASE2
NCT02800785	COMPLETED	Appendicitis	University of Washington	2016-05
NCT04090021	UNKNOWN	Helicobacter Pylori Infection	Konstantopoulio-Patission General Hospital of Nea Ionia	2019-09-01	PHASE4
NCT03658746	COMPLETED	Helicobacter Pylori Infection	Shandong University	2019-01-01	PHASE4
NCT03571230	UNKNOWN	Helicobacter Pylori Infection; Antimicrobial Susceptibility Testing	Shandong University	2018-07-01	PHASE4
NCT04212403	COMPLETED	Urosepsis; Bladder Cancer; Prostate Hyperplasia; Antibiotic Resistant Strain; Antibiotic Resistant Infection; Antibiotic-associated Diarrhea; Antibiotic Toxicity	Jessa Hospital	2018-09-17
NCT02789579	UNKNOWN	Complication of Surgical Procedure	Xinhua Hospital, Shanghai Jiao Tong University School of Medicine	2016-09	EARLY_PHASE1
NCT03148366	COMPLETED	Helicobacter	National Taiwan University Hospital	2015-02	PHASE3
NCT03697993	TERMINATED	Urinary Tract Infection	National Institute of Allergy and Infectious Diseases (NIAID)	2018-11-07	PHASE4
NCT03708848	COMPLETED	Helicobacter Pylori Infection	Shanghai Jiao Tong University School of Medicine	2018-12-05	PHASE4
NCT03159845	COMPLETED	Stem Cell Transplant Complications	Azienda Ospedaliero, Universitaria Pisana	2014-01-01	PHASE2
NCT03472144	UNKNOWN	Chronic Sinusitis, Ethmoidal; Chronic Sinusitis - Ethmoidal Anterior; Chronic Sinusitis; Chronic Sinusitis - Ethmoidal, Posterior; Chronic Sinusitis, Sphenoidal; Chronic Sinusitis - Frontoethmoidal; Nasal Polyps; Nasal Polyp - Posterior	LifeBridge Health	2017-07-07	PHASE3
NCT03658291	UNKNOWN	Urinary Tract Infection Lower Acute	China Academy of Chinese Medical Sciences	2019-01-01	PHASE4
NCT03757234	COMPLETED	Acute Pyelonephritis	Paratek Pharmaceuticals Inc	2018-11-19	PHASE2
NCT02024555	COMPLETED	Sarcoidosis; Antimycobacterial Therapy	Vanderbilt University	2014-03	PHASE2
NCT02067780	COMPLETED	Chronic Obstructive Pulmonary Disease	University of Monastir	2017-05-01	PHASE3
NCT04039412	COMPLETED	Helicobacter Pylori Infection	Ayman Magd Eldin Mohammad Sadek	2018-06-01	PHASE4
NCT03739528	COMPLETED	Cataract	NTC srl	2018-09-03	PHASE3
NCT03740659	COMPLETED	Cataract	NTC srl	2018-09-04	PHASE2
NCT03003273	TERMINATED	Neutropenia, Febrile; Pediatric Cancer	All India Institute of Medical Sciences	2017-01	PHASE3
NCT02901288	UNKNOWN	Tuberculosis, Pulmonary	Beijing Chest Hospital	2016-08	PHASE4
NCT03391440	UNKNOWN	Pelvic Inflammatory Disease	Jiangsu Hansoh Pharmaceutical Co., Ltd.	2016-09	PHASE4
NCT02422706	UNKNOWN	Helicobacter-associated Gastritis	Sherief Abd-Elsalam	2015-01	PHASE3
NCT04456712	COMPLETED	QTc Prolongation, Hyperglycemia, Hypoglycemia	Beni-Suef University	2018-06-01	PHASE4
NCT04352062	COMPLETED	Melatonin Deficiency	Medical University of Lodz	2011-01-09
NCT03413020	COMPLETED	Helicobacter Pylori Infection	Shanghai Jiao Tong University School of Medicine	2018-01-03	PHASE4
NCT03397680	UNKNOWN	Helicobacter Pylori Infection	Thammasat University	2017-05-15	PHASE1
NCT04403334	COMPLETED	Cataract Senile; Endophthalmitis; Antibiotic Side Effect; Safety Issues	Peregrine Eye and Laser Institute	2018-01-02	PHASE4
NCT02741414	UNKNOWN	Gastritis	Taizhou Hospital	2016-06
NCT02757365	UNKNOWN	Prostate Cancer	West China Hospital	2014-04	PHASE4
NCT02789865	UNKNOWN	Acute Appendicitis	First Affiliated Hospital Xi'an Jiaotong University	2016-05	PHASE2
NCT02935010	COMPLETED	Helicobacter Pylori Infection	Shanghai Jiao Tong University School of Medicine	2017-02-05	PHASE4
NCT03160807	UNKNOWN	Urinary Tract Infection	Dr. Reddy's Laboratories Limited	2017-04-15	PHASE4
NCT03087162	COMPLETED	H Pylori Eradication	Ramathibodi Hospital	2017-01-01	PHASE4
NCT03038321	UNKNOWN	Non-Muscle-invasive Bladder Cancer (NMIBC); Bacillus Calmette-Guerin (BCG) Cystitis; Intra-vesical Instillation	Mansoura University	2017-02-01	PHASE4
NCT03032510	COMPLETED	Complicated Urinary Tract Infections	Tetraphase Pharmaceuticals, Inc	2017-01	PHASE3
NCT01988779	COMPLETED	Chronic Rhinosinusitis	University of Rochester	2013-10	PHASE3
NCT02978157	COMPLETED	Helicobacter Pylori Infection	Kaohsiung Veterans General Hospital.	2015-02
NCT02988089	UNKNOWN	Helicobacter Pylori Infection; Antimicrobial Susceptibility Testing	Shandong University	2017-04-20	PHASE4
NCT03139253	UNKNOWN	Antimicrobial Susceptibility Testing; Triple Therapy	Yanqing Li	2017-05-30	PHASE4
NCT03178292	UNKNOWN	Percutaneous Nephrolithotomy; Infection; Sepsis; Antibiotics	Mansoura University	2017-06-15
NCT03138785	UNKNOWN	Treatment	Farabi Eye Hospital	2015-01-01
NCT01371656	COMPLETED	Acute Leukemias of Ambiguous Lineage; Bacterial Infection; Diarrhea; Fungal Infection; Musculoskeletal Complications; Neutropenia; Recurrent Childhood Acute Lymphoblastic Leukemia; Recurrent Childhood Acute Myeloid Leukemia; Secondary Acute Myeloid Leukemia; Untreated Childhood Acute Myeloid Leukemia and Other Myeloid Malignancies	Children's Oncology Group	2011-09	PHASE3
NCT02205112	COMPLETED	Community-acquired Pneumonia	TaiGen Biotechnology Co., Ltd.	2014-06	PHASE3
NCT02573610	COMPLETED	Cataract Surgery	Santen Pharmaceutical Co., Ltd.	2015-09-21	PHASE3
NCT02693574	UNKNOWN	Helicobacter Pylori Gastrointestinal Tract Infection	Damascus Hospital	2015-12-01	PHASE4
NCT02486627	COMPLETED	Complicated Urinary Tract Infection; Acute Pyelonephritis	Achaogen, Inc.	2016-01-11	PHASE3
NCT02466919	COMPLETED	Helicobacter Pylori Infection	Chung-Tai Wu	2014-05	PHASE4
NCT02166476	COMPLETED	Urinary Tract Infection Complicated; Acute Pyelonephritis	Melinta Therapeutics, Inc.	2014-11-20	PHASE3
NCT02600806	UNKNOWN	Community-acquired Pneumonia	Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana	2005-05	PHASE4
NCT01618591	TERMINATED	Acute Watery Diarrhea; Dysentery/Febrile Diarrhea	Uniformed Services University of the Health Sciences	2012-09
NCT01537055	UNKNOWN	Eradication Rate for Helicobacter	National Taiwan University Hospital	2012-02	PHASE4
NCT02596620	COMPLETED	Helicobacter Pylori Infection	Chang Gung Memorial Hospital	2013-10
NCT01978938	COMPLETED	cUTI	Tetraphase Pharmaceuticals, Inc	2014-10-06	PHASE3
NCT02439632	COMPLETED	Acute Lower Urinary Tract Infection	Lee's Pharmaceutical Limited	2014-02	PHASE3
NCT02094703	UNKNOWN	Urinary Tract Infection	Dr Cipto Mangunkusumo General Hospital	2013-04	PHASE4
NCT01875263	TERMINATED	Staphylococcus	Fundación Pública Andaluza Progreso y Salud	2013-05	PHASE3
NCT02018081	COMPLETED	Intensive Care Unit Syndrome; Community-acquired Pneumonia	University Hospital, Toulouse	2012-03	PHASE4
NCT02699658	COMPLETED	Healthy Volunteers	Prince of Songkla University	2013-10	PHASE2
NCT02212795	COMPLETED	Healthy	Dong Wha Pharmaceutical Co. Ltd.	2014-05	PHASE1
NCT02157571	UNKNOWN	Acute Exacerbations of Chronic Bronchitis	Lee's Pharmaceutical Limited	2013-06	PHASE3
NCT02148016	UNKNOWN	Corneal Disease; Pterygium; Myopia; Hyperopia	Sun Yat-sen University	2012-12	PHASE1; PHASE2
NCT01524302	COMPLETED	Pneumonia, Bacterial; Community-acquired	Gary E. Stein, Pharm.D.	2012-02	PHASE4
NCT02884713	COMPLETED	GASTRITIS	King Faisal Specialist Hospital & Research Center	2013-06
NCT02726269	COMPLETED	Helicobacter Pylori Gastritis	Asofarma de México S.A de C.V.	2012-06	PHASE3
NCT01353339	COMPLETED	Disease Due to BK Polyomavirus; Kidney Transplant Infection	Ottawa Hospital Research Institute	2011-12-01	PHASE4
NCT01761201	TERMINATED	Latent Tuberculosis Infection; Infection in Solid Organ Transplant Recipients	Fundación Pública Andaluza para la gestión de la Investigación en Sevilla	2012-01	PHASE3
NCT01109823	COMPLETED	Infection	University Ghent	2010-05-19	PHASE3
NCT02128308	COMPLETED	Healthy	Seoul National University Hospital	2013-11	PHASE1
NCT01710488	COMPLETED	COPD Exacerbation	Fadoi Foundation, Italy	2009-05	PHASE4
NCT01345929	COMPLETED	Complicated Urinary Tract Infection; Pyelonephritis	Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)	2011-06-20	PHASE3
NCT01163435	COMPLETED	Helicobacter Infection	National Taiwan University Hospital	2010-08	PHASE4
NCT02028754	COMPLETED	Dry Eye Syndromes; Cataract	Allergan	2011-07	PHASE4
NCT01742429	COMPLETED	Cure Rate of Helicobacter Pylori Infection	Shanghai Jiao Tong University School of Medicine	2012-11	PHASE4
NCT01270347	COMPLETED	Cystic Fibrosis	Amgen	2011-01	PHASE3
NCT01667718	COMPLETED	Functional Dyspepsia; Peptic Ulcer	Shanghai Jiao Tong University School of Medicine	2012-05	PHASE4
NCT01529476	COMPLETED	Pneumonia	TaiGen Biotechnology Co., Ltd.	2011-04	PHASE3
NCT05339295	COMPLETED	Healthy; Pharmacokintetics	University of Karachi	2012-07-11	PHASE1
NCT01055145	TERMINATED	TB	Seoul National University Hospital	2010-03	PHASE3
NCT01467297	COMPLETED	COPD Exacerbation	University of Milan	2012-01	PHASE4
NCT01034176	COMPLETED	BK Viremia	Brigham and Women's Hospital	2009-02	PHASE4
NCT01180634	COMPLETED	Cystic Fibrosis	Amgen	2010-11-04	PHASE3
NCT01096849	COMPLETED	Complicated Urinary Tract Infection; Acute Pyelonephritis	Achaogen, Inc.	2010-07-13	PHASE2
NCT01081964	TERMINATED	Community Acquired Pneumonia	IASO Pharma Inc.	2010-03	PHASE2
NCT01500837	COMPLETED	Osteoarticular Infection	Assistance Publique - Hôpitaux de Paris	2010-10
NCT00789997	COMPLETED	COPD Exacerbation	Ottawa Hospital Research Institute	2008-11	PHASE2; PHASE3
NCT01131026	COMPLETED	Helicobacter Pylori Infection	Deva Holding A.S.	2010-06	PHASE3
NCT00873626	COMPLETED	Urinary Tract Infection; Fever	Assistance Publique - Hôpitaux de Paris	2009-06	PHASE4
NCT01168713	COMPLETED	Community-Acquired Bacterial Pneumonia	Melinta Therapeutics, Inc.	2010-08	PHASE2
NCT01544517	COMPLETED	Helicobacter Pylori Infection	University of Campania Luigi Vanvitelli	2011-01	PHASE3
NCT01537250	COMPLETED	Community-acquired Pneumonia	TaiGen Biotechnology Co., Ltd.	2009-08	PHASE2
NCT00906048	TERMINATED	Infection	Sanofi	2009-04	PHASE3
NCT00752947	UNKNOWN	Community-Acquired Pneumonia	Beijing Hospital	2008-09	PHASE4
NCT00840333	COMPLETED	Cystic Fibrosis	Amgen	2009-04	PHASE1
NCT01575899	TERMINATED	Helicobacter Pylori Infection	Buddhist Tzu Chi General Hospital	2007-12	PHASE4
NCT00840580	COMPLETED	Cataract Extraction	Alcon Research	2009-01	PHASE4
NCT00816140	COMPLETED	Helicobacter Infections	National Taiwan University Hospital	2007-06	PHASE4
NCT00659646	COMPLETED	Diabetic Foot Ulcer	Innocoll	2008-04	PHASE2
NCT00593567	COMPLETED	Diabetic Foot Ulcer	Innocoll	2007-12	PHASE2
NCT00764582	TERMINATED	Corneal Transplantation	Santen Inc.	2008-09	PHASE4
NCT00250718	TERMINATED	Non-Hodgkin's Lymphoma; Cancer	New Mexico Cancer Research Alliance	2004-10	PHASE2
NCT00752414	COMPLETED	Chronic Obstructive Pulmonary Disease	Amgen	2008-07	PHASE1
NCT00630019	COMPLETED	Cataract	Santen Inc.	2008-02	PHASE4
NCT00362869	TERMINATED	Escherichia Coli Infections	National Institute of Allergy and Infectious Diseases (NIAID)	2008-02	PHASE1
NCT00176306	COMPLETED	Obesity; Critical Illness	Joel Thompson, PhD	2005-01	PHASE4
NCT00703313	COMPLETED	Healthy	Santen Inc.	2008-05	PHASE4
NCT00453349	COMPLETED	Pelvic Inflammatory Disease	Bayer	2007-01	PHASE3
NCT00495339	COMPLETED	Tuberculosis, Pulmonary	Sanofi	2007-06	PHASE4
NCT00402688	COMPLETED	Prostatitis	Johnson & Johnson Pharmaceutical Research & Development, L.L.C.	2006-11	PHASE3
NCT00503490	COMPLETED	Cystic Fibrosis	Amgen	2007-06	PHASE1
NCT00516958	COMPLETED	Foot Ulcer, Diabetic	Oculus Innovative Sciences, Inc.	2007-05	PHASE2
NCT00396084	COMPLETED	Tuberculosis	National Institute of Allergy and Infectious Diseases (NIAID)	2004-02-10	PHASE1; PHASE2
NCT00253955	COMPLETED	Pneumonia	Sanofi	2003-06	PHASE3
NCT00169585	COMPLETED	Prostatic Hyperplasia; Prostatitis	GlaxoSmithKline	2005-03	PHASE3
NCT00079885	COMPLETED	Community Acquired Pneumonia; Bacterial Pneumonia; Cross Infection	Wyeth is now a wholly owned subsidiary of Pfizer	2003-11	PHASE3
NCT00431678	COMPLETED	Pneumonia	Bayer	2004-01	PHASE3
NCT00081575	COMPLETED	Community-Acquired Infections; Bacterial Pneumonia; Cross Infection	Wyeth is now a wholly owned subsidiary of Pfizer	2004-01	PHASE3
NCT00665327	COMPLETED	Pneumonia	Bayer	2002-11	PHASE4
NCT00645073	COMPLETED	Acute Bacterial Sinusitis	Abbott	2003-11	PHASE4
NCT00257036	COMPLETED	Skin Diseases, Infectious; Cellulitis	Johnson & Johnson Pharmaceutical Research & Development, L.L.C.	1991-07	PHASE2; PHASE3
NCT00392275	COMPLETED	Cataract	Indiana University	2002-11	PHASE4
NCT00000796	COMPLETED	HIV Infections; Tuberculosis	National Institute of Allergy and Infectious Diseases (NIAID)
NCT00643734	COMPLETED	Pneumonia	Pfizer	2003-04	PHASE3
NCT00643409	COMPLETED	Maxillary Sinusitis	Pfizer	2003-01	PHASE3
NCT00215007	UNKNOWN	Malignancy; Allogeneic Stem Cell Transplantation	Charite University, Berlin, Germany		PHASE2; PHASE3
NCT00136344	COMPLETED	Endophthalmitis	City, University of London	2003-09
NCT00249210	COMPLETED	Sinusitis; Maxillary Sinusitis	Johnson & Johnson Pharmaceutical Research & Development, L.L.C.	1993-08	PHASE3
NCT00249197	COMPLETED	Skin Diseases, Bacterial	Johnson & Johnson Pharmaceutical Research & Development, L.L.C.	1997-01	PHASE3
NCT00034736	COMPLETED	Pneumonia	Johnson & Johnson Pharmaceutical Research & Development, L.L.C.	2002-08	PHASE3
NCT00236522	COMPLETED	Sinusitis	Johnson & Johnson Pharmaceutical Research & Development, L.L.C.	2002-10	PHASE3
NCT00491049	COMPLETED	Conjunctival Bacterial Flora	Ludwig-Maximilians - University of Munich	2004-09	PHASE4
NCT00002249	COMPLETED	HIV Infections	R W Johnson Pharmaceutical Research Institute		PHASE1
NCT00258089	COMPLETED	Urinary Tract Infections; Bacteriuria; Urologic Diseases; Pyelonephritis; Neurogenic Bladder	Johnson & Johnson Pharmaceutical Research & Development, L.L.C.	1993-06	PHASE3
NCT00005590	COMPLETED	Brain and Central Nervous System Tumors; Breast Cancer; Extragonadal Germ Cell Tumor; Infection; Lung Cancer; Lymphoma; Ovarian Cancer; Small Intestine Cancer; Testicular Germ Cell Tumor; Unspecified Adult Solid Tumor, Protocol Specific	Cancer Research Campaign Clinical Trials Centre	1999-08	PHASE3
NCT00429975	TERMINATED	Pneumonia, Pneumococcal	Hospital Mutua de Terrassa	2004-08	PHASE4
NCT00001033	COMPLETED	HIV Infections; Tuberculosis	National Institute of Allergy and Infectious Diseases (NIAID)		PHASE3
NCT00602589	COMPLETED	Healthy	Johnson & Johnson Pharmaceutical Research & Development, L.L.C.	2002-10	PHASE1
NCT00821782	COMPLETED	Healthy Volunteer	Ortho-McNeil Janssen Scientific Affairs, LLC	2006-06	PHASE1
NCT00239161	TERMINATED	Acute Uncomplicated Pyelonephritis	University of Manitoba	2004-09	PHASE4
NCT00277511	COMPLETED	Prostatitis	Sanofi	2003-03	PHASE3
NCT00236834	COMPLETED	Nosocomial Pneumonia	Johnson & Johnson Pharmaceutical Research & Development, L.L.C.	1997-12	PHASE3
NCT00257049	COMPLETED	Pneumonia	Johnson & Johnson Pharmaceutical Research & Development, L.L.C.	1984-01	PHASE2; PHASE3
NCT00645437	COMPLETED	Renal Diseases	Johnson & Johnson Pharmaceutical Research & Development, L.L.C.	2004-10	PHASE1
NCT00269932	COMPLETED	Bronchitis, Chronic	Johnson & Johnson Pharmaceutical Research & Development, L.L.C.	1993-08	PHASE3
NCT00644449	COMPLETED	Bronchitis, Chronic	Pfizer	2003-01	PHASE3
NCT00000778	COMPLETED	HIV Infections; Tuberculosis	National Institute of Allergy and Infectious Diseases (NIAID)		PHASE1
NCT00565123	COMPLETED	Bacterial Conjunctivitis	Laser Microsurgery Centre, Poland	2004-09	PHASE2; PHASE3
NCT00051753	COMPLETED	Otitis Media	Johnson & Johnson Pharmaceutical Research & Development, L.L.C.	2002-11	PHASE3
NCT00601432	COMPLETED	Healthy	Johnson & Johnson Pharmaceutical Research & Development, L.L.C.	2002-10	PHASE1
NCT00236821	COMPLETED	Pneumonia	Johnson & Johnson Pharmaceutical Research & Development, L.L.C.	2001-03	PHASE3
NCT00236912	TERMINATED	Appendicitis	Johnson & Johnson Pharmaceutical Research & Development, L.L.C.	2003-07	PHASE4
NCT00236808	COMPLETED	Prostatitis	Johnson & Johnson Pharmaceutical Research & Development, L.L.C.	2000-05	PHASE3
NCT00376376	COMPLETED	Healthy Volunteers	Michigan State University	2006-09
NCT00210886	COMPLETED	Urinary Tract Infections; Pyelonephritis	Johnson & Johnson Pharmaceutical Research & Development, L.L.C.	2004-10	PHASE3
NCT00245791	TERMINATED	Complicated Urinary Infection	University of Manitoba	2004-10	PHASE4
NCT00258102	COMPLETED	Urinary Tract Infections; Bacterial Infections; Bacteriuria; Urologic Diseases	Johnson & Johnson Pharmaceutical Research & Development, L.L.C.	1993-01	PHASE3
NCT00257140	COMPLETED	Bronchitis; Bronchitis, Chronic	Johnson & Johnson Pharmaceutical Research & Development, L.L.C.	1931-06	PHASE2; PHASE3
NCT00257062	COMPLETED	Skin Diseases, Infectious	Johnson & Johnson Pharmaceutical Research & Development, L.L.C.	1993-01	PHASE3
NCT00042718	COMPLETED	Bronchitis; Chronic Bronchitis	Johnson & Johnson Pharmaceutical Research & Development, L.L.C.	2001-11	PHASE3
NCT00044473	COMPLETED	Otitis Media	Johnson & Johnson Pharmaceutical Research & Development, L.L.C.	2002-11	PHASE3
NCT00236652	COMPLETED	Maxillary Sinusitis	Johnson & Johnson Pharmaceutical Research & Development, L.L.C.	2003-11	PHASE3
NCT00035347	COMPLETED	Community-Acquired Pneumonia (CAP)	Pfizer	2001-01	PHASE4
NCT00020865	UNKNOWN	Fever, Sweats, and Hot Flashes; Infection; Leukemia; Lymphoma; Neutropenia; Unspecified Adult Solid Tumor, Protocol Specific	Jonsson Comprehensive Cancer Center	2001-09	PHASE3
NCT00164112	COMPLETED	Healthy	Bassett Healthcare	2004-11	PHASE4
NCT00434291	COMPLETED	Community-Acquired Pneumonia	TaiGen Biotechnology Co., Ltd.	2006-12	PHASE2

(data from https://clinicaltrials.gov, updated on 2026-06-30)

Check the Levofloxacin product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Compliance for Clinical Use

Mechanism and Biochemical Profile

Levofloxacin selectively binds to bacterial type II topoisomerases, specifically DNA gyrase and topoisomerase IV, where it inhibits the A subunits to disrupt DNA supercoiling and induce double-stranded chromosome breakage. This inhibition halts bacterial DNA replication and transcription, ultimately leading to bactericidal activity against pathogens evaluated in clinical studies for conditions such as Helicobacter pylori infection, pneumonia, and antibiotic-resistant bacterial infections.

Appendix RUO and cGMP Quality Standards

Quality Dimension	RUO (Research Use Only)	cGMP (Current Good Manufacturing Practice)
Clinical Applicability	Prohibited in human clinical trials or medical diagnostics.	Mandatory for human clinical trials (Phase I–III) and therapies.
Regulatory Status	Non-regulated grade; exempt from drug manufacturing laws.	Legally enforced by health authorities (e.g., FDA, EMA, NMPA).
Facility Environment	Unclassified analytical or research laboratories.	Validated Cleanrooms (ISO Class 5–8) with continuous monitoring.
Quality Control	Basic purity and activity testing.	Rigorous safety release testing (Sterility, Endotoxin, Mycoplasma).
Process Validation	Basic equipment calibration; no process validation required.	Full qualification (IQ/OQ/PQ) and complete batch records.
Quality Assurance	Vendor self-declared without required formal QMS.	Mandatory QA/QC unit, Change Control, CAPA, and vendor audits.
Regulatory Impact	High risk of IND rejection if used as a critical raw material.	Required for IND/NDA filings, supported by Drug Master Files (DMF).

Footnotes

Regulatory Note: Governed by FDA (21 CFR Parts 210/211/312), EMA (EudraLex Vol 4), ICH Guidelines (E6/Q7/Q9/Q10), and compendial standards (USP <71>/<85>/<1043>).