CAS No. 100986-85-4
| IUPAC Name | (2S)-7-fluoro-2-methyl-6-(4-methylpiperazin-1-yl)-10-oxo-4-oxa-1-azatricyclo[7.3.1.05,13]trideca-5(13),6,8,11-tetraene-11-carboxylic acid | |
|---|---|---|
| CAS Number | 100986-85-4 | |
| Molecular Formula |
C18H20FN3O4 |
|
| Molecular Weight (MW) | 361.37 | |
| SMILES | CC1COC2=C3N1C=C(C(=O)C3=CC(=C2N4CCN(CC4)C)F)C(=O)O | |
| InChIKey | GSDSWSVVBLHKDQ-JTQLQIEISA-N |
Levofloxacin is a synthetic fluoroquinolone antibiotic that targets bacterial type II topoisomerases, specifically DNA gyrase and topoisomerase IV. By inhibiting the subunit components of these enzymes, levofloxacin suppresses the supercoiling and unlinking activities required for bacterial genomic DNA processing. This inhibition leads to double-stranded DNA breakage, blocking DNA replication and transcription, which ultimately results in bacterial cell death.
|
Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
18 mg/mL
(49.81 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 18 mg/mL |
| Ethanol | 2 mg/mL |
| DMSO |
55 mg/mL
(152.19 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 17 mg/mL |
| Ethanol | 9 mg/mL |
| DMSO |
24 mg/mL
(66.41 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 21 mg/mL |
| Water | 11 mg/mL |
| DMSO |
72 mg/mL
(199.24 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 8 mg/mL |
| Ethanol | 2 mg/mL |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.