For research use only. Not for use in humans.

Lecanemab (Anti-Amyloid Beta)

Synonyms: BAN-2401 Cat.No.A3112 Purity:99%

Lecanemab (Anti-Amyloid Beta) is a humanized IgG1 monoclonal antibody targeting soluble aggregated amyloid beta (Aβ). It can be used for the research of Alzheimer's Disease. MW :147.06 KD.

1 Citation

17 Nobel Prize winners have used Selleck products

Shimon Sakaguchi

Nature Communications 2025,16, Article number:1325

David Baker

Dev Cell 2023, 58(20):2163-2180.e9.

David Julius

Cell 2017, 185-198.e16

Michael Houghton

Cell Chem Biol, 2020, 27(7):780-792.e5

Charles M. Rice

Cell 2018, 172(3):423-438.e25

Quality Control

Batch: Purity: 99% Protein concentration: 5.451mg/ml Endotoxin Level: ＜1EU/mg

Specificity

Name	Citation	Beta Amyloid	Others
DAPT	398	+++	Notch
RO4929097 (RG-4733)	123	+++	γ secretase,Notch
Semagacestat (LY450139)	22	+++	Notch
MK-0752	23	++++
Avagacestat (BMS-708163)	22	++++
LY2811376	19	++	BACE1
CRANAD-2	0	++
Hoechst 34580	1	+
Frentizole	0	+
Simufilam	0	✔
Ginsenoside Rg1	5	✔	NF-κB
Ginsenoside Re	1	✔	NF-κB,JNK
Tabersonine hydrochloride	0	✔
EUK 134	6	✔

Expand to Check More

1. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation. 2. "✔" indicates inhibitory effect, but without specific value.

Mechanism of Action

Description	Lecanemab (Anti-Amyloid Beta) is a humanized IgG1 monoclonal antibody targeting soluble aggregated amyloid beta (Aβ). It can be used for the research of Alzheimer's Disease. MW :147.06 KD.
References	https://pubmed.ncbi.nlm.nih.gov/36544184/

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID

Product Details

CAS No.	1260393-98-3
Isotype	Human IgG1
Source	CHO
Formulation	100 mM Pro-Ac, 20mM Arg, pH5.0
Storage (From the date of receipt)	Store the undiluted solution at -20°C in the dark to avoid freeze-thaw cycles.

Comparison of Clones for

^*Literature analysis of various clone (for this target) products available on the market shows that Selleck's selected clones are more frequently applied. (data until September 2024)

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