LDN-193189 is a potent, ATP-competitive BMP receptor (ALK1/2/3) inhibitor. It affects the BMP/Smad signaling pathway by blocking Smad1/5/8 phosphorylation, effectively inhibiting tumor progression and osteoblast differentiation while promoting stem cell neural differentiation.
LDN-193189 IC50 for Cell-based and Cell-free Assays
Comprehensive IC50 Values for LDN-193189 Across Cell-free Enzyme Inhibitory Profiles and Cell-based Functional Assays.