CAS No. 1062368-24-4

Batch: Purity:99.43
Check CoA
LDN-193189 Chemical Structure
Chemical Structure
Check the LDN-193189 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline
CAS Number 1062368-24-4
Molecular Formula

C25H22N6
Molecular Weight (MW) 406.48
SMILES C1CN(CCN1)C2=CC=C(C=C2)C3=CN4C(=C(C=N4)C5=CC=NC6=CC=CC=C56)N=C3
InChIKey CDOVNWNANFFLFJ-UHFFFAOYSA-N

Ordering Information

Biological Activity

LDN-193189 is a selective bone morphogenetic protein (BMP) signaling inhibitor that targets BMP type I receptors, including ALK2 and ALK3. It blocks BMP-induced downstream SMAD phosphorylation and transcriptional activation, while also inhibiting non-Smad pathways such as p38, ERK1/2, and AKT in C2C12 cells. Through inhibition of BMP signaling, LDN-193189 suppresses ectopic ossification and demonstrates therapeutic potential in fibrodysplasia ossificans progressiva. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
🧮 Molarity Calculator

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
0.01M HCl 2.5 mg/mL
DMSO Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Aliquotting Service

Free Aliquotting Service

Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.

Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.

Jump to

Note: Technical data last updated: Sep 1, 2026.