Larotrectinib (LOXO-101): Selectivity & Specificity

Larotrectinib (LOXO-101) is a potent inhibitor of TRKA (5-11 nM), TRKB (5-11 nM), TRKC (5-11 nM), TRK (5-11 nM), ETV6-NTRK3 (17 nM), NTRK1, NTRK2, NTRK3, TNK2. Larotrectinib (LOXO-101) exhibits the greatest inhibitory potency toward TRKA (IC50 = 5-11 nM).