Cell-free Assays (IC50/Ki) for Larotrectinib (LOXO-101)
| Key Target | IC50 (Cell-free) | Description | Reference |
|---|---|---|---|
| TRKA, TRKB, TRKC | 5-11 nmol/L | in vitro 50% inhibitory constant | PMC6503327 |
| TRKA kinase | 0.067 µM | TrkA kinase analysis kit ([Vendor] BPS Bioscience), luminescence detection | Download PDF |
| TRK | 5-11 nm | in vitro | Download PDF |
Cell-based Assay (IC50) for Larotrectinib (LOXO-101)
| Cell Type | IC50 (Cell-based) | Description | Reference |
|---|---|---|---|
| TRKA, TRKB, TRKC | 2–20 nmol/L | Cellular potency assay | Download PDF |
| Ba/F3 cells expressing STRN3-NTRK3 | 12 nM | PrestoBlue cell viability assay | PMC10871756 |
| Ba/F3 cells expressing LMNA-NTRK1 | 21 nM | PrestoBlue cell viability assay | PMC10871756 |
| IRC-I-XL | 13.4 nM | Cell Viability Assays | Download PDF |
| Kor1 | 24.8 nM | Cell Viability Assays | Download PDF |
| Ba/F3 LMNA-NTRK1 | 21.8 nM | Cell Viability Assays | Download PDF |
| Ba/F3 ETV6-NTRK2 | 53.6 nM | Cell Viability Assays | Download PDF |
| Ba/F3 ETV6-NTRK3 | 14.2 nM | Cell Viability Assays | Download PDF |
| Ba/F3 LMNA-NTRK1-F589L | 614 nM | Cell Viability Assays | Download PDF |
| Ba/F3 ETV6-NTRK2-F633L | 3113 nM | Cell Viability Assays | Download PDF |
| Ba/F3 ETV6-NTRK3-F617L | 893 nM | Cell Viability Assays | Download PDF |
| Ba/F3 LMNA-NTRK1-G595R | 3204 nM | Cell Viability Assays | Download PDF |
| Ba/F3 ETV6-NTRK2-G639R | 3809 nM | Cell Viability Assays | Download PDF |
| Ba/F3 EVT6-NTRK3-G623R | 962 nM | Cell Viability Assays | Download PDF |
| Ba/F3 ETV6-NTRK3-G623E | 61.3 nM | Cell Viability Assays | Download PDF |
| Ba/F3 LMNA-NTRK1-G667A | 118 nM | Cell Viability Assays | Download PDF |
| Ba/F3 LMNA-NTRK1-G667C | 1368 nM | Cell Viability Assays | Download PDF |
| Ba/F3 LMNA-NTRK1-G667S | 3195 nM | Cell Viability Assays | Download PDF |
| Ba/F3 ETV6-NTRK2-G709C | 2788 nM | Cell Viability Assays | Download PDF |
| Ba/F3 ETV6-NTRK3-G696A | 45.7 nM | Cell Viability Assays | Download PDF |
| Ba/F3 ETV6-NTRK3-G696C | 780 nM | Cell Viability Assays | Download PDF |
| Ba/F3- LMNA-NTRK1-V573M | 45.4 nM | Cell Viability Assays | Download PDF |
| Ba/F3 LMNA-NTRK1-A608D | 19.7 nM | Cell Viability Assays | Download PDF |
| Ba/F3 ETV6-NTRK2-V689M | 13.9 nM | Cell Viability Assays | Download PDF |
Check the
Larotrectinib (LOXO-101)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Jump to
- Larotrectinib (LOXO-101) Mechanism of Action: TRK Inhibition in Tumor Cell Research
- Larotrectinib (LOXO-101) Clinical Trials
- Larotrectinib (LOXO-101) Working Concentration | Cell Culture | Treatment
- Larotrectinib (LOXO-101) Solubility in DMSO
- Larotrectinib (LOXO-101) Stock Solution
- Larotrectinib (LOXO-101) Storage
- Larotrectinib (LOXO-101) Stability
- Larotrectinib (LOXO-101) Combination Database
- Larotrectinib (LOXO-101) Molecular Weight
- Larotrectinib (LOXO-101) SMILES
- Larotrectinib (LOXO-101) CAS Number
- Larotrectinib (LOXO-101) Chemical Structure (2D and 3D)
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