Larotrectinib is a potent ATP-competitive TRK inhibitor. It affects ERK/AKT signaling by blocking TRK, inhibiting tumor growth.
Comprehensive IC50 Values for Larotrectinib (LOXO-101) Across Cell-free Enzyme Inhibitory Profiles and Cell-based Functional Assays.
Larotrectinib is a potent ATP-competitive TRK inhibitor. It affects ERK/AKT signaling by blocking TRK, inhibiting tumor growth.