Lapatinib (GW572016) Selectivity & Specificity

Target Selectivity of Lapatinib (GW572016)

Key Target	IC₅₀	Description	Reference
EGFR	3 nM	cell-free in vitro kinase assay	PMC9872313
HER2	9.2 nM	HER2 enzyme assay	PMC3950883
HER2	10.2 nM	Cell-based assays (SKBR3 L755S cell line)	PMC9279606
EGFR/HER1	10.8 nM	--	PMC4703392
HER2	15 nM	cell-free in vitro kinase assay	PMC9872313
HER2	0.037 µM	HER2 Kinase Assay Kit	PMC12299904
HER2	109 nM	in vitro IC50 for HER2 inhibition	PMC9357092
EGFR	0.13 µM	EGFR Kinase Assay Kit	PMC12299904
HER4	367 nM	--	PMC4703392
mPGES-1	0.8 µM	ELISA assay	PMC7311425
EGFR	1730 nM	Cell-based assays (MDA-MB-468 cell line)	PMC9279606
ER	3000 nM	Cell-based assays (MCF7 Parental cell line)	PMC9279606
β-haematin	5.43 µM	Detergent mediated assay for β-haematin inhibition, using the pyridine-ferrochrome method to measure unreacted haematin.	PMC7180468
mPGES-1	12 µM	ELISA assay	PMC7311425

Check the Lapatinib (GW572016) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.