Lapatinib (GW572016) is a potent, reversible dual EGFR and HER2 tyrosine kinase inhibitor. It affects PI3K/AKT/mTOR and MAPK/ERK signaling pathways by blocking receptor autophosphorylation, inhibiting tumor cell proliferation and promoting apoptosis.
Lapatinib (GW572016) IC50 for Cell-based and Cell-free Assays
Comprehensive IC50 Values for Lapatinib (GW572016) Across Cell-free Enzyme Inhibitory Profiles and Cell-based Functional Assays.