DL-Lactic acid Clinical Trials

Size	Price	Qty
100mg	USD 79
1g	USD 397

Clinical Trials

Numerous clinical trials evaluate lactic acid or lactate monitoring across Early Phase 1 through Phase 4 as well as observational study designs. These investigations address conditions such as hyperlactatemia in septic shock, cardiac arrest, acute pancreatitis, paroxysmal nocturnal hemoglobinuria, and metabolic parameters in surgical or healthy populations. Supported by industry sponsors like NovelMed Therapeutics and academic institutions including the Mayo Clinic and the University of Manitoba, these trials encompass completed, active, recruiting, and not yet recruiting statuses.

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT06701760	NOT_YET_RECRUITING	Traumatic Brain Injury	University of California, Los Angeles	2028-01-10	PHASE2
NCT06950060	ACTIVE_NOT_RECRUITING	Stroke, Chronic; Aging; Cognitive Decline; Motor Dysfunction; Neuroplasticity	University of Alabama at Birmingham	2026-07-15
NCT07774520	RECRUITING	Non-small Cell Lung Cancer(NSCLC); EGFR Mutant	Samsung Medical Center	2026-05-26	PHASE2
NCT06558422	NOT_YET_RECRUITING	Insulin Resistance; Hyperinsulinemia; Metabolic Dysfunction Associated Steatotic Liver Disease; Non-Alcoholic Fatty Liver Disease; Prediabetic State; Obesity	Columbia University	2027-01-01	PHASE1
NCT07733206	NOT_YET_RECRUITING	Sepsis	University Hospital Center of Martinique	2026-09-15
NCT07160426	NOT_YET_RECRUITING	Sepsis	Beth Israel Deaconess Medical Center	2026-07-01	PHASE2
NCT03567824	NOT_YET_RECRUITING	Hypomagnesemia in Type 2 Diabetic Patients	Pharmalyte Solutions LLC	2026-03-01	PHASE2
NCT07635875	RECRUITING	Scar Conditions and Fibrosis of Skin; Scar Quality Assessment and Safety; Scar Tissue	Rigshospitalet, Denmark	2026-04-16	PHASE1; PHASE2
NCT07756476	RECRUITING	Acute Pancreatitis (AP)	University of Southern California	2026-03-19
NCT07426172	RECRUITING	Hyperlactatemia; Metabolic Syndrome (MetS); Lipolysis; Exercise	Ricardo Mora	2026-01-20
NCT07619729	ENROLLING_BY_INVITATION	Diabetes Type 2; Periodontal Disease; Caries	Colgate Palmolive	2026-05-26	PHASE4
NCT07731451	NOT_YET_RECRUITING	Aging Well; Aging	Northern Arizona University	2027-01-01	EARLY_PHASE1
NCT06168175	NOT_YET_RECRUITING	Major Depressive Disorder	Centre Hospitalier Universitaire Vaudois	2024-01	PHASE2
NCT05004610	RECRUITING	Cardiac Arrest; Ischemia Reperfusion Injury; Anoxic Brain Injury	Erasme University Hospital	2025-02-19	PHASE2
NCT07202559	RECRUITING	Pancreatitis, Chronic; Pancreatitis, Acute; Pancreatic Duct Stones	Changhai Hospital	2025-10-13
NCT06541535	RECRUITING	Diabetic Keto-acidosis	Centre Hospitalier Universitaire de Nice	2025-11-26	PHASE4
NCT07212595	RECRUITING	Acute Kidney Injury; Mechanical Ventilation	Dana Fuhrman	2026-07-08	PHASE2
NCT06634069	RECRUITING	Septic Shock; Intracranial Hypertension	University Hospital Pilsen	2024-11-24	PHASE2
NCT04623502	RECRUITING	Kidney Cancer; Renal Cell Carcinoma; Clear Cell Carcinoma; Urothelial Carcinoma; Metastatic Kidney Cancer; Metastatic Urothelial Carcinoma; Papillary Renal Cell Carcinoma; Chromophobe Renal Cell Carcinoma; Fumarate Hydratase Deficiency; Succinate Dehydrogenase-Deficient Renal Cell Carcinoma; HLRCC; Hereditary Leiomyomatosis and Renal Cell Cancer	University of Texas Southwestern Medical Center	2019-09-30
NCT06482463	RECRUITING	Nosocomial Infection	University Hospital, Toulouse	2025-02-12
NCT07329660	NOT_YET_RECRUITING	Transcatheter Aortic Valve Replacement; Hemodynamic Stability; Anesthesia Induction	Air Force Military Medical University, China	2026-02-16
NCT07729943	RECRUITING	Healthy Subjects With Low Energy Levels	Applied Food Sciences Inc.	2026-03-15
NCT06107335	NOT_YET_RECRUITING	Pre-Eclampsia	The University of Texas Health Science Center, Houston	2025-07-01	PHASE4
NCT07683650	RECRUITING	TMJ Disc Displacement With Reduction	Mansoura University	2026-01-06
NCT03704766	RECRUITING	Joint Infection; Infection of Hip Joint (Disorder); Infection of Shoulder Joint; Septic Arthritis	Hospital for Special Surgery, New York	2016-06-28
NCT07738640	NOT_YET_RECRUITING	Endurance Running Performance; Exercise Training Adaptation	Shuqi Jia	2026-08
NCT05036122	WITHDRAWN	Healthy	Mayo Clinic	2026-01
NCT06671106	RECRUITING	Gingivitis	Università degli Studi di Ferrara	2025-01-07
NCT07488078	RECRUITING	Laparoscopic Cholecystectomy	King Edward Medical University	2025-12-01	PHASE1
NCT07035509	NOT_YET_RECRUITING	Septic Shock; Pediatric Critical Illness	Fundación Cardioinfantil Instituto de Cardiología	2025-07-01	PHASE4
NCT07306845	NOT_YET_RECRUITING	Postoperative Outcome; Whipple Procedures	Alexandria University	2025-12-25
NCT07224282	NOT_YET_RECRUITING	Exogenous Ketosis	University of Oklahoma	2025-11-17	EARLY_PHASE1
NCT07124130	RECRUITING	Induced Labor	Eastern Virginia Medical School	2025-09	PHASE4
NCT07263698	COMPLETED	Gingivitis; Plaque, Dental	Colgate Palmolive	2025-12-01	PHASE3
NCT07174128	COMPLETED	Cut-Off Value; Plethysmographic Variability Index; Intraoperative; Fluid Therapy; Serum Lactate; Excision; Supra-Tentorial Brain Tumors	Cairo University	2025-09-20
NCT06030609	COMPLETED	Electrolyte Imbalance; Kidney Transplant; Complications	King Chulalongkorn Memorial Hospital	2024-09-01	PHASE3
NCT07439523	COMPLETED	Recovery Strategies After Simulated 400-meter Sprint in University Athletes	Surabaya State University	2026-02-18
NCT06626984	UNKNOWN	Sepsis; Fluid Overload; Endothelial Dysfunction; Microcirculation	Belfast Health and Social Care Trust	2024-12-01	PHASE1; PHASE2
NCT06602336	ACTIVE_NOT_RECRUITING	Coronary Artery Bypass; Coronary Artery Bypass Graft; Coronary Artery Bypass Graft Surgery (CABG); Valve Replacement; Valve Surgery; Cardiovascular; CABG	Queen Mary University of London	2025-05-20
NCT06487299	UNKNOWN	Iron Deficiency Anemia in Childbirth	The Second Hospital of Nanjing Medical University	2024-07-25	PHASE2
NCT06668714	RECRUITING	Pre Diabetes; Metabolic Syndrome	University of Aarhus	2024-08-22
NCT06063772	NOT_YET_RECRUITING	Hypertension	University of California, San Diego	2025-01	PHASE4
NCT02776488	WITHDRAWN	Brain Injuries, Traumatic	University of California, Los Angeles	2020-09	PHASE2
NCT06126354	WITHDRAWN	Insulin Resistance; Prediabetic State; Non-Alcoholic Fatty Liver Disease; Overweight and Obesity	Columbia University	2024-07-01	PHASE1
NCT06597253	ACTIVE_NOT_RECRUITING	Cardiovascular; Coronary Artery Bypass; Valve Replacement	Queen Mary University of London	2025-02-14
NCT05724134	COMPLETED	Insulin Resistance; Prediabetic State; Hyperinsulinemia; Non-Alcoholic Fatty Liver Disease; Obesity	Columbia University	2023-08-29	PHASE1
NCT07723391	COMPLETED	Donor Hepatectomy; Serum Lactate; Preoperative Carbohydrate Loading	Shifa International Hospital	2024-12-01
NCT07137611	COMPLETED	Exercise Training; BDNF; Cognitive Functions; Lactate Blood Increase	Aksaray University Training and Research Hospital	2025-06-15
NCT06222021	UNKNOWN	Surgical Procedure, Unspecified; Postoperative Complications; Hyperlactatemia; Abdomen Disease	Fondazione Policlinico Universitario Agostino Gemelli IRCCS	2024-02
NCT06370975	UNKNOWN	Fluid Resuscitation	Assiut University	2024-08-01	PHASE1; PHASE2
NCT07146490	COMPLETED	Irisin; Lactate; Cognitive Function; Exercise Training	Aksaray University Training and Research Hospital	2025-06-10
NCT07133061	COMPLETED	Effect of Supplementation on Performance	University of South Bohemia	2024-11-15
NCT06110429	UNKNOWN	Intra Cerebral Hypertension; Lactate Sodium Solution	University Hospital, Geneva	2024-01	PHASE3
NCT05731050	Not yet recruiting	PNH - Paroxysmal Nocturnal Hemoglobinuria	NovelMed Therapeutics	2025-06	Phase 2
NCT07149272	COMPLETED	Fatigue; Lactate; Frailty; Sarcopenia in Elderly; Quality of Life	Dr Cipto Mangunkusumo General Hospital	2024-02-16
NCT07596511	COMPLETED	Healthy Adult Male	Trabzon University	2025-04-15
NCT06835023	RECRUITING	Acute Pancreatitis (AP); Acute Pancreatic Fluid Collection; Fluid Resuscitation	Satu Mare County Emergency Hospital	2022-01-10
NCT06775314	NOT_YET_RECRUITING	Acne Vulgaris	Dr.dr.Irma Bernadette, SpKK (K)	2025-03-01	PHASE3
NCT06466655	COMPLETED	Middle-aged Adults; Major Depressive Disorder	University of Delaware	2024-05-30
NCT06365320	COMPLETED	Lactate; Sports Performance; Metabolomics; Proteomics	Fundació Eurecat	2024-10-04
NCT05646563	Not yet recruiting	Paroxysmal Nocturnal Hemoglobinuria	NovelMed Therapeutics	2025-03	Phase 2
NCT04893382	TERMINATED	Burns	Centre hospitalier de l'Université de Montréal (CHUM)	2021-10-17
NCT06654687	COMPLETED	Pregnancy; Cesarean Delivery; Spinal Anesthesia Induced Hypotension; Cardiac Output Measurement; Volume Status	Sameh Fathy	2024-10-27
NCT05489952	UNKNOWN	Hip Fractures; Fragility Fracture; Osteoporotic Fractures	He Qifei	2022-09-15	PHASE4
NCT05036122	Not yet recruiting	Healthy	Mayo Clinic	2025-02	Not Applicable
NCT06121323	COMPLETED	Heart Failure, Systolic	Henrik Wiggers	2023-11-22
NCT06384469	Not yet recruiting	Rhinoplasty\|Nasal Skin-soft Tissue Envelope Metabolism\|Lactic Acid\|Autologous Cartilage Grafting	University Hospital Sestre Milosrdnice	2025-01-02	--
NCT05646524	Not yet recruiting	Paroxysmal Nocturnal Hemoglobinuria	NovelMed Therapeutics	2025-01	Phase 2
NCT06589856	NOT_YET_RECRUITING	Metabolic Syndrome	University of Aarhus	2024-10
NCT06670742	NOT_YET_RECRUITING	Marathon Runner	National Taiwan Sport University	2024-11-08
NCT06521645	COMPLETED	Endovascular Procedures	Air Force Military Medical University, China	2024-10-30
NCT05917873	COMPLETED	Obesity	University of Aarhus	2023-09-07
NCT02785224	Not yet recruiting	Cardiac Arrest	University of Athens\|University of Thessaly	2024-12	--
NCT06856811	COMPLETED	TMJ Disorder	Sana'a University	2023-08-01
NCT06918314	COMPLETED	Blood Flow Restriction Training; Muscle Oxygenation; Physiological Adaptations	Eastern Mediterranean University	2024-07-01
NCT05381428	COMPLETED	Pancreatitis, Acute	Azienda USL Reggio Emilia - IRCCS	2022-05-13	PHASE3
NCT06221813	COMPLETED	Nipah Virus Infection	Public Health Vaccines LLC	2024-01-26	PHASE1
NCT06265337	COMPLETED	PreDiabetes; Metabolic Syndrome; Insulin Resistance	University of Aarhus	2024-04-11
NCT03117972	TERMINATED	Metastatic Colorectal Cancer	Centre Hospitalier Universitaire de Besancon	2017-08-04	PHASE2
NCT06379815	UNKNOWN	Appetitive Behavior	Wilfrid Laurier University	2024-05-01
NCT06466408	UNKNOWN	Overtraining Syndrome	Shu-Cheng Lin	2024-06-25
NCT07777510	COMPLETED	Supplement	Kocatepe University	2024-05-06
NCT05832047	COMPLETED	Pancreatic Disease	Do Hyun Park	2023-06-19	PHASE4
NCT05355974	COMPLETED	Respiratory Failure; Hypotension and Shock; Hypotension on Induction; Intubation Complication; Anesthesia Intubation Complication	Wright State University	2022-08-09	PHASE3
NCT05924230	UNKNOWN	Post Induction Hypotension	Tata Main Hospital	2023-04-01
NCT06400355	UNKNOWN	Orthognathic Surgery	National Cancer Institute, Egypt	2024-03-01
NCT06508203	COMPLETED	Temporomandibular Joint Disorders	Ain Shams University	2024-01-01
NCT06461390	COMPLETED	Septic Shock; Sepsis	Indonesia University	2024-03-25	PHASE2; PHASE3
NCT05146570	UNKNOWN	Bacterial Meningitis; Fungal Meningitis; Implant Infection	Charite University, Berlin, Germany	2021-06-01
NCT05777135	UNKNOWN	Anesthesia; Ringer's Lactate	National Medical College Birgunj	2023-04-01	PHASE4
NCT03066440	TERMINATED	Diabetic Ketoacidosis	State University of New York at Buffalo	2018-09-01	PHASE4
NCT06196099	COMPLETED	Healthy	Hyunjoong Kim	2023-12-30
NCT05594641	UNKNOWN	Liver Surgery; Remote Ischaemic Preconditioning	Fondazione Policlinico Universitario Agostino Gemelli IRCCS	2022-11-16
NCT05932160	UNKNOWN	Postoperative Nausea and Vomiting	Weifang Medical University	2023-06-01
NCT04046861	COMPLETED	Hyperlactatemia; Cardiac Disease; Bypass Complication; Valve Disease, Heart; Vitamin C	University Medical Centre Maribor	2023-03-01
NCT05318066	ACTIVE_NOT_RECRUITING	Critically Ill Adults in the ICU, Requiring Endotracheal Intubation	Tata Memorial Centre	2022-07-15
NCT03841708	COMPLETED	Cardiac Arrest With Successful Resuscitation	Stefano Malinverni, MD	2019-03-01
NCT05649358	COMPLETED	Hyperlactatemia	University of Alberta	2022-12-05
NCT05810662	UNKNOWN	Fluid and Electrolyte Imbalance	National Cancer Institute, Egypt	2022-09-04
NCT05984186	COMPLETED	Dyspnea; Lactic Acidosis; Muscle; Breathlessness; Exercise; Recovery	Vapotherm, Inc.	2023-03-06
NCT05994092	COMPLETED	Blood Lactate Decrease	Institute of Sport - National Research Institute, Poland	2023-06-10
NCT03679780	COMPLETED	Cardiovascular Diseases; Cardiovascular Risk Factor; Vasoconstriction	The University of Texas at Arlington	2018-10-01	PHASE1
NCT05052619	UNKNOWN	Postoperative Infection; Lactate; Antibiotics	Peking Union Medical College Hospital	2021-07-01
NCT04488874	COMPLETED	Sodium Lactate; Intracranial Hypertension; Brain Relaxation	Centre Hospitalier Universitaire de Besancon	2020-09-29	PHASE3
NCT05703100	COMPLETED	Energy Metabolism	Technical University of Madrid	2023-01-28
NCT04619732	UNKNOWN	Transplant;Failure,Kidney	Accunea Ltd.	2021-07-01
NCT05628571	UNKNOWN	Oral Bacterial Infection	Hospital Israelita Albert Einstein	2023-02-01	PHASE3
NCT05424510	COMPLETED	Hypotension on Induction	Mount Sinai Hospital, Canada	2022-07-05
NCT03528213	COMPLETED	Septic Shock	University Hospital, Lille	2019-10-04	PHASE2; PHASE3
NCT05629780	COMPLETED	Septic Shock	Karolinska University Hospital	2022-09-29
NCT04926740	COMPLETED	Diabetic Ketoacidosis	London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's	2021-10-12
NCT01048138	TERMINATED	Traumatic Brain Injury	Federal University of São Paulo	2018-01-31	PHASE3
NCT04112862	COMPLETED	GLUT1 Deficiency Syndrome; GLUT1DS1; GLUT1DS2; Epilepsy; Lactic Acid Blood Increased; Ketogenic Dieting	Radboud University Medical Center	2022-05-20	EARLY_PHASE1
NCT04432675	COMPLETED	Cesarean Section; Spinal Anesthesia; Parturition	China International Neuroscience Institution	2022-01-30	PHASE4
NCT05098067	COMPLETED	Hyperemesis Gravidarum; Nausea Gravidarum; Vomiting of Pregnancy	Women and Infants Hospital of Rhode Island	2022-05-24	PHASE2
NCT05916352	COMPLETED	Sportive Performance; Caffeine	Cyprus International University	2022-07-04
NCT03129776	TERMINATED	Uterine Cervical Neoplasms	Sunnybrook Health Sciences Centre	2017-11-13	PHASE1
NCT05241054	UNKNOWN	Patient With Nasolacrimal Duct Obstruction; External Dacryocystorhinostomy Operation	Mansoura University	2022-03
NCT03734497	WITHDRAWN	Meniscus Disorder	Diskapi Teaching and Research Hospital	2022-07
NCT04927988	WITHDRAWN	Placenta Accreta Spectrum	Maternal and Child Health Hospital of Foshan	2021-10
NCT05816291	COMPLETED	Lactate Blood Increase; Exhaustion - Physiological	Lindenwood University	2022-03-30
NCT04652375	COMPLETED	Coronary Artery Bypass Graft Surgery; Aortic Valve Replacement	Yale University	2021-07-01
NCT03507062	COMPLETED	SID; Acid-Base Imbalance	Fondazione Policlinico Universitario Agostino Gemelli IRCCS	2017-12-10
NCT04956302	TERMINATED	Recurrent Plasma Cell Myeloma; Refractory Plasma Cell Myeloma	Abdullah Khan	2021-09-27	PHASE1
NCT04141371	TERMINATED	Subarachnoid Hemorrhage, Aneurysmal	Centre Hospitalier Universitaire de Nice	2022-02-14	PHASE3
NCT04230603	UNKNOWN	Tissue Perfusion; Tumor; Inflammation; Inflammatory Bowel Diseases	University of Leipzig	2019-06-06
NCT05958056	COMPLETED	Athletes	University of Jordan	2021-03-01
NCT04983498	WITHDRAWN	Enhanced Recovery Pathway; Endoscopy	Northwestern University	2021-09-01	PHASE4
NCT04381169	TERMINATED	Acute Pancreatitis	Enrique de-Madaria	2020-05-28	PHASE3
NCT05821712	COMPLETED	Plaque; Gum Disease	Colgate Palmolive	2021-03-08	PHASE3
NCT03576534	TERMINATED	Congenital Heart Disease	Boston Children's Hospital	2019-10-03
NCT04238611	UNKNOWN	Exercise; Lactate	Imperial College London	2021-03-01
NCT04710875	COMPLETED	Hyperlactatemia; Healthy; Lactate	University of Aarhus	2021-03-10
NCT03269409	TERMINATED	Osteonecrosis	Mayo Clinic	2017-11-15	PHASE1
NCT04449757	UNKNOWN	Septic Shock; Fluid Resuscitation; Crystalloid Solution; Intensive Care Unit	Zhongnan Hospital	2020-07-01
NCT03685214	UNKNOWN	Sepsis; Acute Kidney Injury; Septic Shock; Sepsis, Severe	ZhiYong Peng	2019-03-01
NCT04051580	COMPLETED	Myocardial Injury	Mahidol University	2019-08-05
NCT04037644	UNKNOWN	Circulatory Failure	University of Milan	2019-07-24	PHASE2; PHASE3
NCT03923816	UNKNOWN	Hepatic Complication	Assiut University	2019-10-01	PHASE1; PHASE2
NCT03325452	COMPLETED	Cardio-respiratory Arrest, Prolactin	Centre Hospitalier Universitaire de Nice	2017-12-19
NCT04299815	COMPLETED	Lactate; Healthy; Hyperlactatemia	University of Aarhus	2020-04-01
NCT04512950	COMPLETED	Fluid Therapy	Ottawa Hospital Research Institute	2016-08-15	PHASE4
NCT03563378	UNKNOWN	Biliary Atresia Intrahepatic Syndromic Form	RenJi Hospital	2018-07-28
NCT06217549	COMPLETED	Ozone Therapy; Exercise Performance	Istanbul University	2019-08-12
NCT03764085	COMPLETED	Sepsis; Intoxication; Septic	Yuria-Pharm	2016-12-06	PHASE4
NCT03822052	COMPLETED	Induction of Labor Affected Fetus / Newborn	Ascension Health	2019-03-15
NCT03980678	UNKNOWN	Exercise-Induced Lactic Acidemia; Lactate Blood Increase	University College Dublin	2019-06
NCT03697330	COMPLETED	Intraoperative Complications	Assiut University	2018-01-28	PHASE2
NCT03565367	COMPLETED	Malignant Central Nervous System Neoplasm; Metastatic Malignant Neoplasm in the Central Nervous System	Daniel M. Spielman	2018-11-06	PHASE1
NCT04291989	COMPLETED	Blood Lactic Acid Increased; Hip Fractures	University Hospitals, Leicester	2018-07-18
NCT03478618	UNKNOWN	Hypotension Drug-Induced	Assiut University	2018-03	EARLY_PHASE1
NCT03537898	COMPLETED	Critical Illness; Acidosis, Metabolic	Vanderbilt University Medical Center	2018-06-01
NCT03782961	UNKNOWN	Vaginal Dryness; Menopausal Women	Farmoquimica S.A.	2019-01-14	PHASE4
NCT01770912	COMPLETED	Pain	University of Florida	2013-03	PHASE2
NCT02866552	UNKNOWN	Systemic Sclerosis	Assistance Publique Hopitaux De Marseille	2017-01	PHASE2
NCT03649009	UNKNOWN	Hyperlactatemia	Universiti Kebangsaan Malaysia Medical Centre	2018-01-01
NCT02558543	TERMINATED	Scleroderma, Systemic	Assistance Publique Hopitaux De Marseille	2015-09	PHASE2
NCT03723993	WITHDRAWN	Lactic Acidosis	Fayoum University	2018-01-15
NCT03700346	COMPLETED	Septic Shock	Military Hospital of Tunis	2018-01-01
NCT03054922	COMPLETED	Anesthesia	Nationwide Children's Hospital	2017-02-23	PHASE3
NCT03118362	COMPLETED	Severe Burns; Fluid Resuscitation	Assistance Publique - Hôpitaux de Paris	2017-08-09	PHASE3
NCT03340805	COMPLETED	Shock, Septic	Children's Hospital of Philadelphia	2018-01-24	PHASE1
NCT03215862	NOT_YET_RECRUITING	Post-ERCP Acute Pancreatitis	University of South Florida	2017-08-01
NCT02807727	UNKNOWN	Reperfusion Injury	Nkanyiso Hadebe	2017-01	PHASE2; PHASE3
NCT03115060	UNKNOWN	Acid-Base Balance Disorder	Post Graduate Institute of Medical Education and Research, Chandigarh	2015-04-01	PHASE4
NCT03078712	COMPLETED	Septic Shock; Hyperlactatemia; Peripheral Perfusion	Pontificia Universidad Catolica de Chile	2017-03-01
NCT02709044	UNKNOWN	Pancreatitis	University Hospital Rijeka	2016-02	PHASE2; PHASE3
NCT02327611	COMPLETED	Thoracoabdominal Aortic Aneurysms	Scientific Institute San Raffaele	2015-02	PHASE4
NCT02721485	COMPLETED	Fluid Therapy	Ottawa Hospital Research Institute	2016-07
NCT02726620	COMPLETED	Hypotension	Vanderbilt University Medical Center	2017-01-05
NCT02365363	COMPLETED	Diabetes Prevention; Obesity Prevention	University of Manitoba	2016-10
NCT01573507	COMPLETED	Traumatic Brain Injury; Subarachnoid Hemorrhage	Centre Hospitalier Universitaire Vaudois	2012-03
NCT03103373	UNKNOWN	Anesthesia	Federal University of Juiz de Fora	2017-02-01
NCT02727881	UNKNOWN	Age-related Macular Degeneration	Ohr Pharmaceutical Inc.	2016-04-12	PHASE3
NCT03133767	COMPLETED	Fluid Loss; Symptom Complex, Triple; Emergencies	Nicholas M Mohr	2017-05-23	PHASE4
NCT02895659	COMPLETED	Critical Illness	Insel Gruppe AG, University Hospital Bern	2016-12-01	PHASE4
NCT03680638	COMPLETED	Cardiovascular Diseases; Cardiovascular Risk Factor; Vasodilation	The University of Texas at Arlington	2016-09-07	PHASE1
NCT02782520	COMPLETED	Right Ventricular Impaired Function; Hypovolemia	University Hospital, Grenoble	2016-08	PHASE3
NCT03043131	UNKNOWN	Cardiopulmonary Bypass	Post Graduate Institute of Medical Education and Research, Chandigarh	2017-02-10	PHASE3
NCT02727946	UNKNOWN	Multiple Trauma	Assiut University	2016-05
NCT03221920	UNKNOWN	Diet Modification; Colorectal Adenocarcinoma; Systemic Inflammation; TNF Alpha; Lactate	Dr. Soetomo General Hospital	2017-08-05
NCT02370927	COMPLETED	Diabetes Prevention; Obesity Prevention	University of Manitoba	2016-05
NCT03761979	COMPLETED	Low Bone Density; Osteopenia; Osteoporosis, Postmenopausal	BioLink Life Sciences, Inc.	2017-03-09
NCT02467387	COMPLETED	Non-Ischemic Heart Failure	CardioCell LLC	2014-06-01	PHASE2
NCT03286816	COMPLETED	Type 1 Diabetes Mellitus With Hypoglycemia	Radboud University Medical Center	2016-11
NCT02418663	UNKNOWN	Actual Impaired Fluid Volume	McGill University Health Centre/Research Institute of the McGill University Health Centre	2015-06
NCT02657278	COMPLETED	Peripheral Arterial Disease	Liverpool University Hospitals NHS Foundation Trust	2016-01
NCT02821546	COMPLETED	Pancreatitis	Mahidol University	2014-08	PHASE3
NCT02368795	UNKNOWN	Pancreatitis	Tehran University of Medical Sciences	2015-02
NCT02449928	UNKNOWN	Severe Sepsis With Septic Shock; Lactate	Peking Union Medical College Hospital	2015-09
NCT01337934	COMPLETED	Septic Shock; Severe Sepsis	University of Sao Paulo	2013-10	PHASE3
NCT02638623	COMPLETED	Osteoarthritis	West Virginia University	2015-10
NCT01980459	COMPLETED	Non-Insulin Dependent Diabetes Mellitus	George Washington University	2013-10	PHASE1
NCT02609360	UNKNOWN	Acute Respiratory Failure	Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico	2013-05
NCT02641561	COMPLETED	Post-ERCP Acute Pancreatitis	The Cooper Health System	2014-10	PHASE3
NCT02028208	COMPLETED	Contact Dermatitis	Allerderm	2013-11-04	PHASE2
NCT02634255	UNKNOWN	Inguinal Hernia; Acute Appendicitis	Diskapi Yildirim Beyazit Education and Research Hospital	2015-12	PHASE3
NCT02643693	COMPLETED	Smoking	Philip Morris Products S.A.	2015-11
NCT02308293	COMPLETED	Type 1 Diabetes Mellitus; Hypoglycemia Unawareness	Radboud University Medical Center	2015-01
NCT02631356	UNKNOWN	Blood Viscosity	First Affiliated Hospital, Sun Yat-Sen University	2015-11	PHASE4
NCT02575170	COMPLETED	Hypothermia	B.P. Koirala Institute of Health Sciences	2013-06
NCT02511613	WITHDRAWN	Age-Related Macular Degeneration	Ohr Pharmaceutical Inc.	2015-07	PHASE2
NCT02791984	COMPLETED	Cardiovascular System	Hospices Civils de Lyon	2015-04
NCT02361736	COMPLETED	Total Fluid Volume Increased	Yuanyuan Zhang	2015-03
NCT01524913	COMPLETED	Temporomandibular Joint Dysfunction; Pain; Arthrocentesis	Emory University	2012-01	PHASE4
NCT01497392	COMPLETED	Adenocarcinoma of the Pancreas; Stage III Pancreatic Cancer; Stage IV Pancreatic Cancer; Unspecified Adult Solid Tumor, Protocol Specific	Roswell Park Cancer Institute	2012-03-29	PHASE1
NCT01634815	TERMINATED	Chronic Critical Ischemia	University Hospital, Strasbourg, France	2013-02-04
NCT02308891	COMPLETED	Post-ERCP Acute Pancreatitis	Dankook University	2014-11
NCT02270723	UNKNOWN	Hemorrhage; Complicating Delivery, Coagulation Defect	Kirsten Cleemann Rasmussen	2014-08	PHASE4
NCT00981305	COMPLETED	Sexual Dysfunction; Breast Cancer Survivors	Seoul National University Hospital	2009-09	PHASE3
NCT01242293	COMPLETED	Labor Stage, First; Labor Stage, Second	HaEmek Medical Center, Israel	2010-11
NCT01428050	UNKNOWN	Pancreaticoduodenectomy	Thomas Jefferson University	2011-05	PHASE2
NCT02108782	WITHDRAWN	Gastrinoma; Glucagonoma; Insulinoma; Pancreatic Polypeptide Tumor; Recurrent Islet Cell Carcinoma; Somatostatinoma	Academic and Community Cancer Research United	2014-10	PHASE2
NCT01678963	COMPLETED	Neovascular Age Related Macular Degeneration	Ohr Pharmaceutical Inc.	2012-11	PHASE2
NCT02569008	COMPLETED	Post Cardiac Surgery	St George's, University of London	2014-01
NCT02314429	COMPLETED	Vaginosis, Bacterial	University Ghent	2014-09	PHASE1
NCT02566460	COMPLETED	Septic Shock	Peking Union Medical College Hospital	2013-01
NCT02614937	COMPLETED	Retinal Vein Occlusion; Macular Edema	Ohr Pharmaceutical Inc.	2013-04	PHASE1; PHASE2
NCT01692769	COMPLETED	Trauma	London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's	2013-05	PHASE4
NCT01769183	COMPLETED	Retinal Neovascularization	Elman Retina Group	2013-02	PHASE2
NCT02318355	COMPLETED	Hemodilution; Hemorrhage; Shock; Wounds and Injuries	Wake Forest University Health Sciences	2013-11
NCT01610986	COMPLETED	Normal Physiology on Healthy Subjects	University of Lausanne	2012-05
NCT01587963	TERMINATED	Shock	Rutgers, The State University of New Jersey	2013-02	PHASE2
NCT02379936	COMPLETED	Neonatal; Asphyxia	National Children's Hospital, Vietnam	2013-08
NCT00752453	COMPLETED	Acute Renal Failure	University Hospital, Ghent	2008-07-31
NCT02064075	COMPLETED	Subarachnoid Hemorrhage	University of Debrecen	2013-02	PHASE4
NCT01624519	UNKNOWN	Blood Lactate Analysis	University of California, Los Angeles	2012-08
NCT01825720	COMPLETED	Valvular Heart Disease	Yonsei University	2013-03
NCT01444508	UNKNOWN	Bloodloss	K. C. Rasmussen	2011-09	PHASE4
NCT01110005	COMPLETED	Ketosis	Milton S. Hershey Medical Center	2010-04
NCT01088997	TERMINATED	Persistent Fetal Circulation Syndrome	Children's Hospital of Philadelphia	2010-06
NCT01515969	TERMINATED	Non-small Cell Lung Cancer (NSCLC), Recurrent; Non-small Cell Lung Cancer (NSCLC), Stage IV	Heather Wakelee	2012-07	PHASE1
NCT00860704	COMPLETED	Goal Directed Fluid Therapy	Medical University of Vienna	2007-11	PHASE4
NCT00797589	COMPLETED	Valve Surgery; Coronary Artery Bypass Grafting	University of Helsinki	2009-01	PHASE4
NCT00787176	TERMINATED	Pregnancy; Labor Pain	Northwestern University	2007-09
NCT01236833	UNKNOWN	Intestinal Disease; Feeding Disorder Neonatal	McGill University Health Centre/Research Institute of the McGill University Health Centre	2010-11	PHASE2
NCT01473537	COMPLETED	Dental Caries	Karolinska Institutet	2011-10	PHASE1
NCT01483092	COMPLETED	Iron Absorption; Gut Bacteria	Swiss Federal Institute of Technology	2011-08
NCT01445990	COMPLETED	Postoperative Complications	Narcisse Zwetyenga	2010-01
NCT01344499	COMPLETED	Laparoscopic Hysterectomy	University Hospital, Gasthuisberg	2009-08
NCT01108601	UNKNOWN	Hearing Loss	McGill University Health Centre/Research Institute of the McGill University Health Centre	2008-04	PHASE1; PHASE2
NCT01119170	COMPLETED	Acidosis	Société des Produits Nestlé (SPN)	2010-05
NCT01334658	COMPLETED	Cataract	Grupo de Estudos em Oftalmologia Clínica e Cirúrgica	2010-08
NCT01293266	COMPLETED	Metabolic Acidosis	University Hospital Schleswig-Holstein	2009-06
NCT00991627	COMPLETED	Pregnancy; Cesarean Section; Anesthesia,Spinal; Hypotension	University of Parma	2009-09	PHASE4
NCT01102634	UNKNOWN	Healthy Subjects	The Hong Kong Polytechnic University	2010-04
NCT01004198	COMPLETED	Shock, Hemorrhagic; Shock, Traumatic; Acidosis, Lactic	Sangart	2009-12	PHASE2
NCT01455376	COMPLETED	Traumatic Brain Injury	Universitas Padjadjaran	2010-03
NCT01111123	COMPLETED	Plaque Psoriasis	Icahn School of Medicine at Mount Sinai	2009-01	PHASE4
NCT01013090	COMPLETED	Cesarean Section	Nanjing Medical University	2009-07
NCT01116609	COMPLETED	Healthy	University of Aarhus	2004-10
NCT01310790	COMPLETED	Shock, Septic	Chinese Septic Shock Network	2006-10	PHASE4
NCT00431743	UNKNOWN	Breast Surgery	Rigshospitalet, Denmark	2009-04	PHASE4
NCT00467922	COMPLETED	Crohn's Disease; Ulcerative Colitis; Rectal Cancer; Colon Cancer; Colon Polyps; Rectal Polyps; Diverticulitis	Corewell Health West	2007-05	PHASE3
NCT00973414	COMPLETED	Cesarean Section	Nanjing Medical University	2009-03
NCT00973791	COMPLETED	Cesarean Section	Nanjing Medical University	2008-10
NCT01654653	COMPLETED	Coronary Heart Disease	Innogene Kalbiotech Pte. Ltd	2008-07	PHASE4
NCT00549419	COMPLETED	Major Abdominal Surgery	Klinikum Ludwigshafen	2007-10	PHASE4
NCT00905502	COMPLETED	Morbid Obesity; Acidosis; Intra-Abdominal Abscess; Hemorrhage; Reflux; Vomiting	Tel-Aviv Sourasky Medical Center	2007-04
NCT00372502	COMPLETED	Severe Sepsis; Septic Shock	National Institute of General Medical Sciences (NIGMS)	2007-01
NCT00202228	COMPLETED	HIV Infections; AIDS; Lactic Acidosis; Lipodystrophy	Queen's University	2002-07	PHASE4
NCT00801359	COMPLETED	Cataract	University of Sao Paulo	2008-01	PHASE2
NCT01388907	COMPLETED	Uterine Fibroids; Fertility Disorders	Medtronic - MITG	2006-05	PHASE4
NCT00282659	COMPLETED	Coronary Artery Disease; Hypertension; Dyslipidemia; Diabetes	Hartford Hospital	2006-01	PHASE4
NCT00270673	COMPLETED	Tissue Hypoxia; Hyperlactatemia	Erasmus Medical Center	2006-02	PHASE3
NCT00425334	COMPLETED	Blood Loss, Surgical; Prostate Cancer; Surgery	Sangart	2005-07	PHASE2
NCT00244920	WITHDRAWN	Prostate Cancer	OHSU Knight Cancer Institute	2002-01	PHASE2
NCT00094120	TERMINATED	Macular Degeneration	Genaera Corporation	2004-10	PHASE2
NCT00494949	COMPLETED	Hypotension; Hypoxia	Sangart	2003-04	PHASE1; PHASE2
NCT01647997	COMPLETED	Sepsis	University of Lausanne	2002-04
NCT00031057	COMPLETED	HIV Infections	National Institute of Allergy and Infectious Diseases (NIAID)
NCT07621627	COMPLETED	Chronic Renal Failure (CRF); Dialysis Dependent Chronic Kidney Disease	Karolinska Institutet	1997-09-09	PHASE3
NCT00037063	WITHDRAWN	HIV Infections	National Institute of Allergy and Infectious Diseases (NIAID)
NCT00139282	TERMINATED	"Wet" Age-Related Macular Degeneration	Genaera Corporation	2005-06	PHASE3
NCT00319345	TERMINATED	Severe Trauma Brain Injury; Intracranial Hypertension	Institut d'Anesthesiologie des Alpes Maritimes	2003-11	PHASE2; PHASE3
NCT00333476	TERMINATED	Macular Degeneration	Genaera Corporation	2006-05	PHASE2
NCT00529711	COMPLETED	Low Cardiac Output	Innogene Kalbiotech Pte. Ltd	2005-07	PHASE3
NCT00542516	COMPLETED	Hip Replacement Arthroplasty	University of Sao Paulo	2006-09	PHASE4
NCT00929461	COMPLETED	Gastric Surgery	Ege University
NCT00197886	COMPLETED	Septic Shock	Herlev Hospital	2004-10
NCT00282620	UNKNOWN	Arrhythmia; Quality of Life; Hypomagnesemia	Hartford Hospital	2006-01	PHASE4
NCT00021385	UNKNOWN	Ovarian Cancer	Jonsson Comprehensive Cancer Center	2001-05	PHASE2
NCT00005764	COMPLETED	HIV Infections; Lipodystrophy	Glaxo Wellcome	2000-05	PHASE4

(data from https://clinicaltrials.gov, updated on 2026-01-16)

Check the DL-Lactic acid product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Compliance for Clinical Use

Mechanism and Biochemical Profile

As an essential metabolic product of anaerobic glycolysis, DL-lactic acid acts as a key biochemical substrate and cellular signal that modulates intracellular pH, energy balance, and redox states. Systemic monitoring and regulation of lactate dynamics reflect tissue perfusion and oxygenation status, serving as a critical diagnostic and hemodynamic indicator in clinical conditions such as hyperlactatemia, tissue hypoxia, and cardiac arrest.

Appendix RUO and cGMP Quality Standards

Quality Dimension	RUO (Research Use Only)	cGMP (Current Good Manufacturing Practice)
Clinical Applicability	Prohibited in human clinical trials or medical diagnostics.	Mandatory for human clinical trials (Phase I–III) and therapies.
Regulatory Status	Non-regulated grade; exempt from drug manufacturing laws.	Legally enforced by health authorities (e.g., FDA, EMA, NMPA).
Facility Environment	Unclassified analytical or research laboratories.	Validated Cleanrooms (ISO Class 5–8) with continuous monitoring.
Quality Control	Basic purity and activity testing.	Rigorous safety release testing (Sterility, Endotoxin, Mycoplasma).
Process Validation	Basic equipment calibration; no process validation required.	Full qualification (IQ/OQ/PQ) and complete batch records.
Quality Assurance	Vendor self-declared without required formal QMS.	Mandatory QA/QC unit, Change Control, CAPA, and vendor audits.
Regulatory Impact	High risk of IND rejection if used as a critical raw material.	Required for IND/NDA filings, supported by Drug Master Files (DMF).

Footnotes

Regulatory Note: Governed by FDA (21 CFR Parts 210/211/312), EMA (EudraLex Vol 4), ICH Guidelines (E6/Q7/Q9/Q10), and compendial standards (USP <71>/<85>/<1043>).