Eltanexor (KPT-8602) is a selective XPO1 inhibitor. It affects MAPK, STAT3, and p53 signaling pathways by binding to XPO1 and blocking nuclear export, effectively inhibiting cancer cell proliferation and promoting apoptosis.
Comprehensive IC50 Values for Eltanexor (KPT-8602) Across Cell-free Enzyme Inhibitory Profiles and Cell-based Functional Assays.
Eltanexor (KPT-8602) is a selective XPO1 inhibitor. It affects MAPK, STAT3, and p53 signaling pathways by binding to XPO1 and blocking nuclear export, effectively inhibiting cancer cell proliferation and promoting apoptosis.