(+)-JQ1: Selectivity & Specificity
(+)-JQ1 is a potent inhibitor of BRD4(1) (21 nM), BRD4 BD1 (105.7 nM), BRD2 (77 nM), BRD4 (33 nM), BRD3, BRDT, MYC, VEGF, IL6, TNF, NOS2, IL1RN, SLAMF1, IRF8, MXD1, IL19, IFITM1, GBP2, IFNB, DUSP2, SERPINE1, IL1B, IFNB1, ISG15, IFNG, RELA, E2F1, BATF3, IRF4, Tat, CDK9, SWI/SNF complex, ELL2, CCND1, CDK4, RB1, E2F3, CDKN1A, CDKN1B, TWIST1, SNAI1, SNAI2, P-TEFb complex, SIRT1, HEXIM1, CASP9, CYCS. (+)-JQ1 exhibits the greatest inhibitory potency toward BRD4(1) (IC50 = 21 nM).