CAS No. 1268524-70-4
| IUPAC Name | tert-butyl 2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]acetate | |
|---|---|---|
| CAS Number | 1268524-70-4 | |
| Molecular Formula |
C23H25ClN4O2S |
|
| Molecular Weight (MW) | 456.99 | |
| SMILES | CC1=C(SC2=C1C(=NC(C3=NN=C(N32)C)CC(=O)OC(C)(C)C)C4=CC=C(C=C4)Cl)C | |
| InChIKey | DNVXATUJJDPFDM-KRWDZBQOSA-N |
(+)-JQ1 is a potent BET bromodomain inhibitor that selectively targets bromodomains within the BET family, including BRD4, while sparing non-BET bromodomains. By competitively binding to acetyl-lysine recognition pockets, (+)-JQ1 displaces BET proteins from chromatin and disrupts transcriptional gene regulation. Downstream, (+)-JQ1 downregulates oncogenic target genes, suppresses cell proliferation, and induces autophagy across various cancer models. [1]
|
Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
91 mg/mL
(199.12 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 91 mg/mL |
| Water | Insoluble |
| DMSO |
91 mg/mL
(199.12 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 91 mg/mL |
| Water | Insoluble |
| DMSO |
91 mg/mL
(199.12 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 91 mg/mL |
| Water | Insoluble |
| DMSO |
91 mg/mL
(199.12 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 91 mg/mL |
| Water | Insoluble |
| DMSO |
91 mg/mL
(199.12 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 91 mg/mL |
| Water | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- (+)-JQ1 Mechanism of Action: BRD4 Inhibition in Tumor Cell Research
- (+)-JQ1: Selectivity & Specificity
- (+)-JQ1 Working Concentration | Cell Culture | Treatment
- (+)-JQ1 Solubility in DMSO
- (+)-JQ1 Stock Solution
- (+)-JQ1 Storage
- (+)-JQ1 Stability
- (+)-JQ1 Combination Database
- (+)-JQ1 Molecular Weight
- (+)-JQ1 SMILES
- (+)-JQ1 Chemical Structure (2D and 3D)
- (+)-JQ1 IC50 for Cell-based and Cell-free Assays
- (+)-JQ1 Sigma (SML1524)? Try a better option.
- (+)-JQ1 MedChemExpress (HY-13030)? Try a better option.
- (+)-JQ1 Tocris (4499)? Try a better option.
- (+)-JQ1 Cell Signaling Technology (84566)? Try a better option.
- (+)-JQ1 Abcam (ab141498)? Try a better option.
- (+)-JQ1 SDS｜MSDS