Clinical Trials

Numerous clinical trials spanning Early Phase 1 through Phase 4 evaluate ivabradine across various cardiovascular and autonomic conditions, including congestive heart failure, atrial fibrillation, inappropriate sinus tachycardia, and postural tachycardia syndrome. Supported by academic institutions such as Yale University and pharmaceutical sponsors like Institut de Recherches Internationales Servier, these protocols encompass completed, recruiting, active, and terminated statuses. These investigations evaluate ivabradine's therapeutic impact across diverse patient populations, including comparative trials against beta-blocker therapy.

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT07268170 ENROLLING_BY_INVITATION
Coronary Arterial Disease (CAD); Ischemic Heart Disease (IHD)
Gødstrup Hospital
 2025-12-15 PHASE2; PHASE3
NCT07135258 NOT_YET_RECRUITING
Atrial Fibrillation (Permanent); Atrial Fibrillation (AF)
The University of Hong Kong
 2025-10-01 PHASE4
NCT07714746 RECRUITING
Cardiogenic Shock Post Myocardial Infarction
National Institute of Cardiovascular Diseases, Pakistan
 2026-04-20 PHASE3
NCT07797946 NOT_YET_RECRUITING
Hemodynamic Instability
Minia University
 2026-08-01
NCT05882708 RECRUITING
Sepsis; Ivabradine; Hemodynamics; Heart Rate Control
Second Affiliated Hospital of Guangzhou Medical University
 2023-06-01 PHASE4
NCT07717710 NOT_YET_RECRUITING
Healthy Adult
University of British Columbia
 2026-08-01 EARLY_PHASE1
NCT04031573 COMPLETED
Septic Shock
Assistance Publique - Hôpitaux de Paris
 2021-02-26 PHASE3
NCT04186286 RECRUITING
Postural Tachycardia Syndrome
University of Calgary
 2021-02-01 PHASE2
NCT06305806 COMPLETED
Long COVID; Long Covid19; Long Covid-19
Kanecia Obie Zimmerman
 2024-03-11 PHASE2
NCT06305780 COMPLETED
Long COVID; Long Covid19; Long Covid-19
Kanecia Obie Zimmerman
 2024-03-11 PHASE2
NCT04853797 COMPLETED
Headache; Migraine Without Aura
Danish Headache Center
 2021-05-11
NCT06505668 UNKNOWN
Treatment Resistant Schizophrenia; Clozapine Adverse Reaction; Heart Rate Variability; Tachycardia
All India Institute of Medical Sciences, Bhubaneswar
 2023-08-01
NCT06742164 NOT_YET_RECRUITING
Heart Rhythm Disorder
Ain Shams University
 2024-12-30
NCT05279651 ACTIVE_NOT_RECRUITING
Myocardial Injury After Noncardiac Surgery (MINS); Myocardial Ischemia
Jagiellonian University
 2022-06-13 PHASE3
NCT04111133 UNKNOWN
Cirrhotic Cardiomyopathy; Left Ventricular Dysfunction; Cirrhosis, Liver; Portal Hypertension
Post Graduate Institute of Medical Education and Research, Chandigarh
 2020-01-01
NCT05481177 UNKNOWN
Long Haul COVID; Postural Orthostatic Tachycardia Syndrome
Uniformed Services University of the Health Sciences
 2023-06-14 PHASE4
NCT06371222 COMPLETED
Mitral Stenosis
Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
 2023-02-01 PHASE4
NCT01868880 WITHDRAWN
Heart Rate Control in ICD Patients With Heart Failure
Policlinico Casilino ASL RMB
 2016-02 PHASE4
NCT06670690 COMPLETED
Intraoperative Bleeding
Menoufia University
 2023-09-01
NCT05594342 UNKNOWN
Heart Failure; Cardiogenic Shock; Ischemic Heart Disease
The Young Investigator Group of Cardiovascular Research
 2022-07-01 PHASE3
NCT02973594 COMPLETED
Dilated Cardiomyopathies, Idiopathic; Heart Failure, Systolic; Ventricular Remodeling; Electrical Remodeling
University of Colorado, Denver
 2016-11 PHASE4
NCT05348057 UNKNOWN
Cardiovascular Diseases
Qian geng
 2021-08-01 PHASE4
NCT05261464 UNKNOWN
Heart Rate; Coronary Computed Tomography Angiography
Mahidol University
 2021-01-30 PHASE4
NCT05141071 COMPLETED
Septic Shock
Cairo University
 2021-11-25 PHASE2
NCT03718273 COMPLETED
Atrial Fibrillation; Heart Diseases
Adolfo Fontenla
 2018-10-19 PHASE3
NCT04436016 COMPLETED
Myocardial Injury; Myocardial Ischemia
University Hospital, Geneva
 2020-10-05 PHASE4
NCT03650205 UNKNOWN
Neoplasms; Heart Failure; Cardiotoxicity; Chemotherapy Effect; Oncology
University of Sao Paulo
 2019-01-22
NCT03631654 WITHDRAWN
Heart Failure NYHA Class IV
University of Maryland, Baltimore
 2020-10-01 PHASE4
NCT03105219 WITHDRAWN
Diabetic Kidney Disease
Nanjing First Hospital, Nanjing Medical University
 2017-07-01 PHASE3
NCT04448899 COMPLETED
Congestive Heart Failure
Damanhour University
 2020-06-01 PHASE4
NCT04580342 UNKNOWN
Hypotension
Ahmed talaat ahmed aly
 2020-10-15 PHASE2
NCT04405804 UNKNOWN
Acute Heart Failure; Dilated Cardiomyopathy
Bambino Gesù Hospital and Research Institute
 2020-06-20 PHASE2
NCT03367026 UNKNOWN
Sepsis, Severe
Peking Union Medical College Hospital
 2018-01-01
NCT04308031 UNKNOWN
Atrial Fibrillation; Ivabradine; Heart Failure
Chun-Yao Huang
 2018-08-26 PHASE3
NCT03137537 TERMINATED
Lymphoma; Autonomic Imbalance; Cancer Survivorship
Dana-Farber Cancer Institute
 2018-02-27 PHASE2
NCT03168529 TERMINATED
Heart Failure
Phillip Levy
 2018-07-01 PHASE4
NCT04030546 UNKNOWN
Patients With Cancer
Vilnius University
 2019-06-01 PHASE3
NCT03182725 COMPLETED
Postural Orthostatic Tachycardia Syndrome
University of California, San Diego
 2018-02-06 PHASE3
NCT04208594 UNKNOWN
Ivabradine; Propranolol; Hypotensive Anesthesia
Alexandria University
 2019-12-11
NCT03619187 WITHDRAWN
Heart Transplantation, Elevated Resting Heart Rate
Amgen
 2018-11-02 PHASE3
NCT03387605 UNKNOWN
Heart Failure; Cardiogenic Shock; Tachycardia
Loyola University
 2018-03-15 PHASE4
NCT03701880 UNKNOWN
Heart Failure With Reduced Ejection Fraction; Decompensated Heart Failure
Ain Shams University
 2018-09-16
NCT03830957 UNKNOWN
Heart Failure; CT Angiography; Ischemic Cardiomyopathy; Non-ischemic Cardiomyopathy; Heart Failure, Systolic; Heart Failure，Congestive; Heart Failure, Diastolic; Heart Rate Low
Rajaie Cardiovascular Medical and Research Center
 2018-11-26
NCT03405831 UNKNOWN
Cardiac Allograft Vasculopathy; Transplanted Heart Complication
Finn Gustafsson
 2018-04-17 PHASE4
NCT03437369 UNKNOWN
Cardiogenic Shock
Hospital Universitario Ramon y Cajal
 2018-05 PHASE4
NCT03987204 COMPLETED
Atrial Fibrillation; Atrial Fibrillation, Persistent
Yale University
 2019-06-15 PHASE1
NCT02584439 COMPLETED
Healthy; Vascular Stiffness; Aging
University Hospital, Rouen
 2015-12-03 PHASE3
NCT03456856 COMPLETED
Heart Failure (HF)
Amgen
 2017-09-28 PHASE4
NCT02827500 COMPLETED
Heart Failure
Duke University
 2016-07 PHASE4
NCT03485482 COMPLETED
Cardiovascular Diseases
Ain Shams University
 2018-03-01 PHASE3
NCT02188082 UNKNOWN
Chronic Systolic Heart Failure
Jiangsu HengRui Medicine Co., Ltd.
 2014-05 PHASE2; PHASE3
NCT02623569 UNKNOWN
Angina Pectoris
Xintong Pharmacy Company
 2014-10 PHASE2
NCT03866395 COMPLETED
Angina Pectoris, Stable
Azienda Policlinico Umberto I
 2015-03-05 PHASE4
NCT02236247 UNKNOWN
Decompensated Heart Failure
University of Sao Paulo
 2013-05 PHASE1; PHASE2
NCT01657136 COMPLETED
Inappropriate Sinus Tachycardia
Policlinico Casilino ASL RMB
 2013-09 PHASE3
NCT03245996 COMPLETED
Aortic Blood Pressure
Tartu University Hospital
 2015-06 PHASE4
NCT02294292 COMPLETED
Diastolic Dysfunction; Chronic Liver Disease
Institute of Liver and Biliary Sciences, India
 2014-07-01
NCT02166060 UNKNOWN
Heart Failure
Medical University of Warsaw
 2014-08 PHASE4
NCT04285736 COMPLETED
NSTEMI
Cairo University
 2014-12 PHASE2; PHASE3
NCT02507050 WITHDRAWN
Coronary Artery Disease; Angina
Liverpool Heart and Chest Hospital NHS Foundation Trust
 2016-03 PHASE4
NCT02247245 COMPLETED
Chronic Heart Failure; Atrial Fibrillation; Arrhythmia, Sinus
University of Leeds
 2014-09
NCT02086422 UNKNOWN
Chronic Heart Failure
The Leeds Teaching Hospitals NHS Trust
 2013-07
NCT02681978 COMPLETED
Coronary Artery Disease
Campus Bio-Medico University
 2014-02 PHASE4
NCT01755663 UNKNOWN
Coronary Artery Disease
Col. Suthee Panichkul
 2014-12 PHASE4
NCT01768585 UNKNOWN
Coronary Artery Disease; Coronary Arteriosclerosis
University Hospital, Saarland
 2012-12 PHASE4
NCT02046044 UNKNOWN
Heart Failure
Kocaeli University
 2014-01 PHASE4
NCT02446990 COMPLETED
Coronary Artery Disease
Institut de Recherches Internationales Servier
 2009-09 PHASE3
NCT02354573 COMPLETED
Heart Failure
University of Oxford
 2011-12
NCT00757055 WITHDRAWN
Diastolic Heart Failure
St Vincent's University Hospital, Ireland
 2012-12 PHASE2
NCT01039389 COMPLETED
Coronary Artery Disease
Insel Gruppe AG, University Hospital Bern
 2009-10
NCT01761825 UNKNOWN
Postural Tachycardia Syndrome
Tel-Aviv Sourasky Medical Center
 2012-12 PHASE2
NCT01425164 UNKNOWN
Coronary Heart Disease; Angina; Hemodialysis
University of Campania Luigi Vanvitelli
 2011-01 PHASE4
NCT01699776 COMPLETED
Cardiac Failure
Cocco, Giuseppe, M.D.
 2008-04 PHASE4
NCT01029223 WITHDRAWN
Blood Pressure
Bayside Health
 2008-10 PHASE4
NCT00825123 TERMINATED
Central Arterial Pressure
Bayside Health
 2008-10 PHASE4
NCT01186783 UNKNOWN
Multiple Organ Dysfunction Syndrome
Martin-Luther-Universität Halle-Wittenberg
 2010-05 PHASE2
NCT00815100 COMPLETED
Acute Coronary Syndromes
Hospital Universitario de Canarias
 2009-04 PHASE4
NCT01365286 COMPLETED
Asthma, Chronic Obstructive Pulmonary Disease (COPD)
Medical University of Lodz
 2009-05 PHASE4
NCT01373619 COMPLETED
Heart Failure
University of Campania Luigi Vanvitelli
 2010-01 PHASE4
NCT01364077 UNKNOWN
High Heart Rate
University of Campania Luigi Vanvitelli
 2010-01 PHASE4
NCT00865917 UNKNOWN
Postural Orthostatic Tachycardia Syndrome
Hannover Medical School
 2008-11 PHASE2
NCT01022463 COMPLETED
Mitral Stenosis
Govind Ballabh Pant Hospital
 2009-11 PHASE3
NCT01178528 COMPLETED
Heart Failure
IRCCS San Raffaele
 2009-09 PHASE3
NCT02441218 COMPLETED
Chronic Heart Failure
Institut de Recherches Internationales Servier
 2006-09 PHASE3
NCT00143507 COMPLETED
Coronary Disease; Ventricular Dysfunction, Left
Institut de Recherches Internationales Servier
 2004-12 PHASE3
NCT01804010 COMPLETED
Healthy Individual
Asan Medical Center
 2007-05 PHASE1
NCT00202579 COMPLETED
Heart Failure, Congestive
Institut de Recherches Internationales Servier
 2004-09 PHASE2
NCT00202566 COMPLETED
Angina Pectoris
Institut de Recherches Internationales Servier
 2005-06 PHASE3

(data from https://clinicaltrials.gov, updated on 2025-12-17)

Check the Ivabradine HCl product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Compliance for Clinical Use

Mechanism and Biochemical Profile

Ivabradine HCl selectively binds to and inhibits hyperpolarization-activated cyclic nucleotide-gated ($I_f$) channels in the sinoatrial node, blocking the ionic pacemaker current responsible for cardiac automaticity. This channel blockade slows the rate of spontaneous diastolic depolarization in sinoatrial pacemaker cells, reducing heart rate and providing clinical utility in conditions such as congestive heart failure, inappropriate sinus tachycardia, and atrial fibrillation without altering myocardial contractility.

Appendix RUO and cGMP Quality Standards

Quality Dimension RUO (Research Use Only) cGMP (Current Good Manufacturing Practice)
Clinical Applicability Prohibited in human clinical trials or medical diagnostics. Mandatory for human clinical trials (Phase I–III) and therapies.
Regulatory Status Non-regulated grade; exempt from drug manufacturing laws. Legally enforced by health authorities (e.g., FDA, EMA, NMPA).
Facility Environment Unclassified analytical or research laboratories. Validated Cleanrooms (ISO Class 5–8) with continuous monitoring.
Quality Control Basic purity and activity testing. Rigorous safety release testing (Sterility, Endotoxin, Mycoplasma).
Process Validation Basic equipment calibration; no process validation required. Full qualification (IQ/OQ/PQ) and complete batch records.
Quality Assurance Vendor self-declared without required formal QMS. Mandatory QA/QC unit, Change Control, CAPA, and vendor audits.
Regulatory Impact High risk of IND rejection if used as a critical raw material. Required for IND/NDA filings, supported by Drug Master Files (DMF).

Footnotes

Regulatory Note: Governed by FDA (21 CFR Parts 210/211/312), EMA (EudraLex Vol 4), ICH Guidelines (E6/Q7/Q9/Q10), and compendial standards (USP <71>/<85>/<1043>).

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Note: Technical data last updated: Sep 1, 2026.