CAS No. 148849-67-6
Batch:
Purity:99.74
Chemical Structure
Check the
Ivabradine HCl
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 3-[3-[[(7S)-3,4-dimethoxy-7-bicyclo[4.2.0]octa-1,3,5-trienyl]methyl-methylamino]propyl]-7,8-dimethoxy-2,5-dihydro-1H-3-benzazepin-4-one;hydrochloride | |
|---|---|---|
| CAS Number | 148849-67-6 | |
| Molecular Formula |
C27H36N2O5.HCl |
|
| Molecular Weight (MW) | 505.05 | |
| SMILES | CN(CCCN1CCC2=CC(=C(C=C2CC1=O)OC)OC)CC3CC4=CC(=C(C=C34)OC)OC.Cl | |
| InChIKey | HLUKNZUABFFNQS-ZMBIFBSDSA-N |
Biological Activity
Ivabradine HCl is a selective hyperpolarization-activated cyclic nucleotide-gated (HCN) channel blocker that selectively inhibits the cardiac pacemaker If current. By targeting HCN channels in the sinoatrial node, it suppresses spontaneous diastolic depolarization and slows the pacemaker firing rate without altering cardiac contractility or ventricular repolarization pathways. This selective mechanism reduces heart rate through precise modulation of cardiac ionic currents. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
101 mg/mL
(199.98 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 101 mg/mL |
| Water | 82 mg/mL |
| DMSO |
100 mg/mL
(198.0 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 100 mg/mL |
| Ethanol | 100 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer longer shelf life compared to stock solutions.
Looking for a specific aliquot size? Contact your local sales representative or orders@selleckchem.com.
Reference
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Note: Technical data last updated: Sep 1, 2026.