ISRIB is a potent eIF2B activator and integrated stress response (ISR) inhibitor. It affects PERK/eIF2α/ATF4 signaling by promoting eIF2B decamer assembly and blocking eIF2α-P-dependent downstream signaling, effectively restoring protein synthesis, suppressing stress granule formation, and mitigating ER stress-induced apoptosis.
ISRIB: Mechanism of Action
ISRIB MOA：Targeting eIF2B/Integrated Stress Response for Cognitive Impairment and Traumatic Brain Injury