ISRIB is a potent eIF2B activator and integrated stress response (ISR) inhibitor. It affects PERK/eIF2α/ATF4 signaling by promoting eIF2B decamer assembly and blocking eIF2α-P-dependent downstream signaling, effectively restoring protein synthesis, suppressing stress granule formation, and mitigating ER stress-induced apoptosis.
ISRIB IC50 for Cell-based and Cell-free Assays
Comprehensive IC50 Values for ISRIB Across Cell-free Enzyme Inhibitory Profiles and Cell-based Functional Assays.