CAS No. 241479-67-4
Batch:
Purity:99.99
Chemical Structure
Check the
Isavuconazole
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 4-[2-[(2R,3R)-3-(2,5-difluorophenyl)-3-hydroxy-4-(1,2,4-triazol-1-yl)butan-2-yl]-1,3-thiazol-4-yl]benzonitrile | |
|---|---|---|
| CAS Number | 241479-67-4 | |
| Molecular Formula |
C22H17F2N5OS |
|
| Molecular Weight (MW) | 437.47 | |
| SMILES | CC(C1=NC(=CS1)C2=CC=C(C=C2)C#N)C(CN3C=NC=N3)(C4=C(C=CC(=C4)F)F)O | |
| InChIKey | DDFOUSQFMYRUQK-RCDICMHDSA-N |
Isavuconazole (BAL-4815) is an extended-spectrum triazole antifungal agent that inhibits cytochrome P450-dependent 14α-lanosterol demethylation (CYP51). By blocking CYP51, it disrupts ergosterol biosynthesis in fungal cell membranes, leading to depletion of ergosterol and accumulation of toxic methylated sterol precursors. This impairs membrane integrity and cellular viability, demonstrating broad-spectrum activity against yeasts, molds, and dimorphic fungi. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
87 mg/mL
(198.87 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 87 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.