CAS No. 1646321-63-2

Batch: Purity:99.97
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LNP023 (Iptacopan) Hydrochloride Chemical Structure
Chemical Structure
Check the LNP023 (Iptacopan) Hydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 4-[(2S,4S)-4-ethoxy-1-[(5-methoxy-7-methyl-1H-indol-4-yl)methyl]piperidin-2-yl]benzoic acid;hydrochloride
CAS Number 1646321-63-2
Molecular Formula

C25H31ClN2O4
Molecular Weight (MW) 458.98
InChIKey SEZXOFFLNHXEJE-CQERKEQDSA-N

Ordering Information

Biological Activity

LNP023 (Iptacopan) Hydrochloride is an orally bioavailable complement factor B inhibitor (IC=, Kd = that exhibits high selectivity over other proteases. By directly binding to factor B, it blocks the assembly of C3 and C5 convertases within the alternative complement pathway. This proximal pathway blockade suppresses membrane attack complex assembly, thereby preventing complement-mediated erythrocyte hemolysis and attenuating inflammatory tissue injury. [1][2]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 85 mg/mL (185.19 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 85 mg/mL
Water 5 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.