Eganelisib (IPI-549): Mechanism of Action

Eganelisib (IPI-549) MOA:Targeting PI3Kγ/PI3K-AKT Pathway for Solid Tumor Immunotherapy

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Eganelisib (IPI-549) is a selective PI3Kγ inhibitor. It affects PI3K/AKT/MAPK signaling by downregulating AKT phosphorylation, effectively promoting T cell expansion, driving M1 macrophage polarization, and alleviating MDSC-mediated immunosuppression.

Primary Applications and Mechanism of Action