CAS No. 127-07-1
Batch:
Purity:100.0
Chemical Structure
Check the
Hydroxyurea
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | hydroxyurea | |
|---|---|---|
| CAS Number | 127-07-1 | |
| Molecular Formula |
CH4N2O2 |
|
| Molecular Weight (MW) | 76.05 | |
| SMILES | C(=O)(N)NO | |
| InChIKey | VSNHCAURESNICA-UHFFFAOYSA-N |
Hydroxyurea is an antineoplastic agent that inhibits ribonucleoside diphosphate reductase by inactivating its M2 subunit. By quenching the tyrosyl free radical at the active site, it selectively impairs DNA synthesis and damages DNA repair mechanisms, leading to S-phase cell cycle arrest, apoptosis, and autophagy. Additionally, hydroxyurea elevates fetal hemoglobin levels through nitric oxide-mediated activation of soluble guanylyl cyclase. [1][2]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
15 mg/mL
(197.23 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 15 mg/mL |
| Ethanol | Insoluble |
| DMSO |
15 mg/mL
(197.23 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 15 mg/mL |
| Ethanol | Insoluble |
| DMSO |
15 mg/mL
(197.23 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 15 mg/mL |
| Ethanol | Insoluble |
| DMSO |
15 mg/mL
(197.23 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 15 mg/mL |
| Ethanol | Insoluble |
| DMSO |
15 mg/mL
(197.23 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 15 mg/mL |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- Hydroxyurea Mechanism of Action: Ribonucleotide Reductase Inhibition in Erythroid Precursor Cell Research
- Hydroxyurea Clinical Trials
- Hydroxyurea: Selectivity & Specificity
- Hydroxyurea Working Concentration | Cell Culture | Treatment
- Hydroxyurea Solubility in DMSO
- Hydroxyurea Stock Solution
- Hydroxyurea Storage
- Hydroxyurea Stability
- Hydroxyurea Combination Database
- Hydroxyurea Molecular Weight
- Hydroxyurea SMILES
- Hydroxyurea Chemical Structure (2D and 3D)
- Hydroxyurea IC50 for Cell-based and Cell-free Assays
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- Hydroxyurea SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.