Clinical Trials

Numerous clinical trials evaluate heparin across Early Phase 1 through Phase 4, focusing on cardiovascular and thromboembolic disorders, severe respiratory conditions including COVID-19, and catheter-related infections, alongside complications like heparin-induced thrombocytopenia. Sponsored by both pharmaceutical companies and academic medical centers, these studies encompass diverse recruitment statuses ranging from active and completed to terminated or suspended.

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06494878 RECRUITING
Venous Thromboembolism; Postpartum Period; Aspirin; Low Molecular Weight Heparin
University of Calgary
 2026-06-04 PHASE3
NCT07140211 RECRUITING
Venous Thromboembolism (VTE); Postpartum
Marc Blondon
 2025-10-15 PHASE3
NCT07783880 NOT_YET_RECRUITING
Myocardial Infarction; Percutaneous Coronary Intervention (PCI); Medical Treatment; Coronary Computed Tomographic Angiography; Computed Tomography; Optical Coherence Tomography (OCT)
3W-Research Collaboration Group
 2026-10-01
NCT06753786 RECRUITING
Venous Thromboembolism; Pulmonary Embolism; Intracerebral Hemorrhage; Deep Vein Thrombosis
Pirogov Russian National Research Medical University
 2024-10-21
NCT06381661 RECRUITING
Sepsis
Assistance Publique - Hôpitaux de Paris
 2026-07-09 PHASE2
NCT06714864 RECRUITING
Catheter-Related Infections
CorMedix Therapeutics
 2025-07-08 PHASE4
NCT06453876 RECRUITING
Pulmonary Embolism
Jesper Kjaergaard
 2026-06-17 PHASE3
NCT05848713 RECRUITING
Community-acquired Pneumonia
University of Manitoba
 2023-10-10 PHASE3
NCT06861374 NOT_YET_RECRUITING
ST-segment Elevation Myocardial Infarction (STEMI)
First Affiliated Hospital Xi'an Jiaotong University
 2025-05
NCT06869291 ENROLLING_BY_INVITATION
Xanthelasma Palpebrarum
Fuzhou First General Hospital Skin Disease Prevention and Control Hospital
 2025-02-01
NCT05701917 RECRUITING
Venous Thromboembolism; Deep Venous Thrombosis; Post-Thrombotic Syndrome
Inari Medical
 2023-01-06
NCT06676085 RECRUITING
ECMO
Beijing Chao Yang Hospital
 2024-11-01
NCT07383155 NOT_YET_RECRUITING
Percutaneous Coronary Intervention; High Bleeding Risk; Acute Coronary Syndromes; Anticoagulant Therapy
Shenyang Northern Hospital
 2026-02-01 PHASE4
NCT03244020 ENROLLING_BY_INVITATION
Sarcoma; Soft Tissue Sarcoma; Bone Sarcoma; Bone Metastases; Venous Thromboembolism; Hematoma; Anticoagulant-induced Bleeding
Massachusetts General Hospital
 2018-02-16 PHASE4
NCT06937372 NOT_YET_RECRUITING
Hip Fractures; Venous Thromboembolism (VTE)
Queen Mary University of London
 2026-08-01
NCT06080074 RECRUITING
Heart Failure; Cardiogenic Shock; Congenital Heart Disease; Cardiomyopathies
Stanford University
 2025-04-15 PHASE2
NCT07228663 NOT_YET_RECRUITING
Hip Fracture Surgery; Cardiovascular Prevention; Venous Thromboembolism (VTE)
McMaster University
 2025-12-01 PHASE3
NCT07352800 RECRUITING
Peripheral Arterial Occlusive Disease; Chronic Limb-Threatening Ischemia
Aplagon Oy
 2026-01-29 PHASE2
NCT05879835 RECRUITING
Pediatric Intestinal Failure
SterileCare Inc.
 2024-06-21
NCT06215378 RECRUITING
Aortic Valve Stenosis; Heart Valve Diseases
Assistance Publique - Hôpitaux de Paris
 2025-05-25 PHASE3
NCT04725201 RECRUITING
Amputation; Traumatic, Hand
Centre hospitalier de l'Université de Montréal (CHUM)
 2021-05-24 PHASE4
NCT07250763 ACTIVE_NOT_RECRUITING
Pulmonary Embolism; Deep Vein Thrombosis; Atrial Fibrillation; Acute Cardiac Syndrome; Mechanical Heart Valve Recipients
Inova Health Care Services
 2023-09-20 PHASE4
NCT06442267 RECRUITING
Respiratory Insufficiency; Circulatory Failure; Thromboembolism; Bleeding
Medical University of Vienna
 2024-07-30 PHASE4
NCT04273607 RECRUITING
Extracorporeal Membrane Oxygenation Complication
Damian Ratano
 2022-09-01 PHASE2; PHASE3
NCT07286409 NOT_YET_RECRUITING
Respiratory Distress Syndrome; Mechanical Ventilation Complication
Tanta University
 2026-01
NCT05117450 RECRUITING
Renal Insufficiency
CHU de Reims
 2021-11-17
NCT07609771 NOT_YET_RECRUITING
Acute Pancreatitis (AP)
Allied Hospital Faisalabad
 2026-06 PHASE4
NCT07361679 RECRUITING
Preeclampsia Severe; Toxemia Of Pregnancy; Preeclampsia; Pregnancy Complications; Hypertension, Pregnancy-Induced; Gestational Hypertension
Alexandra Hospital, Athens, Greece
 2023-01-18 PHASE4
NCT04374799 RECRUITING
Cardiac Disease
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
 2020-10-05 PHASE3
NCT06981624 RECRUITING
Radial Artery Occlusion
Olivier F. Bertrand
 2025-05-13
NCT04762992 ENROLLING_BY_INVITATION
Fetal Growth Retardation; Prematurity; Pre-Eclampsia
Centro Hospitalar de Lisboa Central
 2022-07-18 PHASE3
NCT05959252 RECRUITING
Extracorporeal Membrane Oxygenation Complication
Sydney Local Health District
 2024-05-01 PHASE2
NCT07477977 RECRUITING
Open Heart Surgery
Sohag University
 2026-03-01
NCT05737121 RECRUITING
Interstitial Cystitis; Bladder Pain Syndrome
Vaneltix Pharma, Inc.
 2023-05-22 PHASE2
NCT07270263 RECRUITING
Lymphoma; Leukemia; Multiple Myeloma (MM), Lymphoma, Large B-Cell, Diffuse (DLBCL), Lymphoma; Venous Thromboembolic Disease; VTE (Venous Thromboembolism); PE - Pulmonary Embolism; Hematologic Malignacies
Medical University of Gdansk
 2024-11-22
NCT06033300 RECRUITING
Heparin-induced Thrombocytopenia; HIT; Platelet Activation; Platelets; Leukocytes; Platelet/Leukocyte Aggregates; HITSTREAM; Flow Cytometry
Centre Hospitalier Universitaire, Amiens
 2023-04-17
NCT07388927 NOT_YET_RECRUITING
Ecchymosis After Periorbital Rejuvenation With Botulinum Toxin Type A; Crow's Feet Lines; Lateral Canthal Lines, LCL
DKSH Management (Thailand) Limited
 2026-02 PHASE4
NCT05257213 RECRUITING
Intrauterine Adhesion
Nadezhda Women's Health Hospital
 2022-02-14
NCT06281028 COMPLETED
Dialysis Membrane Reaction
GCS Ramsay Santé pour l'Enseignement et la Recherche
 2024-11-20
NCT07162064 COMPLETED
Acute Ischemic Stroke
Xiang Luo
 2025-08-04 PHASE3
NCT06776159 RECRUITING
CVD - Cardiovascular Disease; Bruise; Pain
The Hong Kong Polytechnic University
 2025-06-24
NCT02246270 COMPLETED
Recurrent Urinary Tract Infections
University of Oklahoma
 2017-11-28 EARLY_PHASE1
NCT05984537 RECRUITING
Coronary Microvascular Dysfunction
Peking University First Hospital
 2023-07-01 PHASE4
NCT04561648 UNKNOWN
Radial Artery Occlusion
Instituto Nacional de Cardiologia Ignacio Chavez
 2020-08-01
NCT06150742 RECRUITING
Acute Kidney Injury
Talphera, Inc
 2024-08-15
NCT05634057 RECRUITING
Sepsis
Chen Ying
 2024-01-25
NCT05785819 TERMINATED
Thrombocytopenia, Immune; Heparin Induced Thrombocytopenia
Veralox Therapeutics
 2023-09-26 PHASE2
NCT06112262 NOT_YET_RECRUITING
Haemodialysis
Basma Rabiey
 2023-12-20 EARLY_PHASE1
NCT05148026 COMPLETED
ARDS, Human; Acute Kidney Injury
University of Milano Bicocca
 2021-11-14
NCT06020560 UNKNOWN
Anticoagulant; Venous Thromboembolism; Prophylaxis; Treatment
Herlev Hospital
 2023-03-23 PHASE4
NCT04496362 ACTIVE_NOT_RECRUITING
ECMO; Heparin; Respiratory Failure
Baylor Research Institute
 2018-10-10 PHASE4
NCT05247424 COMPLETED
STEMI - ST Elevation Myocardial Infarction
University Medical Centre Ljubljana
 2022-03-10 PHASE4
NCT07124819 COMPLETED
Arthroplasty, Replacement, Hip; Arthroplasty, Replacement, Knee; Venous Thromboembolism (VTE); Prevention
Avexima Diol LLC
 2024-07-22 PHASE3
NCT05382481 UNKNOWN
Venous Thromboembolism
Xuanwu Hospital, Beijing
 2022-05-16
NCT03302195 RECRUITING
Cardiopulmonary Bypass; Obesity
Laval University
 2015-08-21
NCT05204550 COMPLETED
COVID-19
Murdoch Childrens Research Institute
 2023-01-30 PHASE2; PHASE3
NCT06517563 COMPLETED
Coagulation Disorder
VarmX B.V.
 2024-08-14 PHASE1
NCT06355258 RECRUITING
COVID 19 Associated Coagulopathy
Westlake University
 2023-12-15 PHASE1
NCT05953675 UNKNOWN
Hemodialysis Catheter-Associated Bacteremia; Hemodialysis Complication
Zealand University Hospital
 2018-08-01
NCT07366372 COMPLETED
Taurolidine; Lock Solution; Prevention; Central Venous Catheter Infection; Intensive Care Unit
Tanta University
 2023-05-01
NCT04049591 RECRUITING
Cardiovascular Diseases; Percutaneous Coronary Intervention
Population Health Research Institute
 2022-03-02
NCT05555641 UNKNOWN
Critical Illness; Anticoagulation
Xiaobo Yang, MD
 2022-12-20 PHASE2
NCT06829407 COMPLETED
Pain, Acute; Injection Site
Trakya University
 2024-08-20
NCT05226442 COMPLETED
Extracorporeal Membrane Oxygenation Complication; Anticoagulants and Bleeding Disorders
Medical University of Vienna
 2021-12-01 PHASE2; PHASE3
NCT05886998 COMPLETED
Smoke Inhalation Injury; Acute Lung Injury
Ain Shams University
 2023-06-01 PHASE3
NCT06469112 COMPLETED
Pain; Asthma; Pulmonary Disease; Chest Disorder
Uludag University
 2023-12-01
NCT04545541 COMPLETED
Covid19; Respiratory Failure
Australian National University
 2020-11-01 PHASE2; PHASE3
NCT06154018 COMPLETED
Cardiac Surgery; CAD; Valve Heart Disease; Coagulation Disorder
University of Ioannina
 2023-03-18
NCT04061798 TERMINATED
Abdominal Aortic Aneurysm; Surgery; Arterial Disease
Dijklander Ziekenhuis
 2020-03-02 PHASE4
NCT05749393 UNKNOWN
Intracranial Aneurysm
The First Affiliated Hospital with Nanjing Medical University
 2023-04-30
NCT04645550 COMPLETED
Cirrhosis; Splenectomy; Status; Venous Thrombosis; Hypertension, Portal
Northern Jiangsu People's Hospital
 2020-11-22 PHASE4
NCT05604859 UNKNOWN
Severe Fever With Thrombocytopenia Syndrome
Qin Ning
 2022-08-19 PHASE4
NCT04925167 COMPLETED
Respiratory Failure
Beijing Chao Yang Hospital
 2021-07-06
NCT04861922 UNKNOWN
Sepsis; Gram-Negative Bacterial Infections; Heparin
The Third Xiangya Hospital of Central South University
 2021-05-11 PHASE3
NCT02653092 ACTIVE_NOT_RECRUITING
Obesity; Infertility; Hypogonadotropic Hypogonadotropism; Hyperinsulinemia
University of Colorado, Denver
 2016-06
NCT03261284 UNKNOWN
Extracorporeal Membrane Oxygenation Complication; Thrombosis; Hemorrhage; Heparin Overdose
Wuhan Asia Heart Hospital
 2019-03-01
NCT05184101 WITHDRAWN
COVID-19
Australian National University
 2023-08 PHASE2; PHASE3
NCT05740150 UNKNOWN
Central Line-associated Bloodstream Infection (CLABSI)
Princess Maxima Center for Pediatric Oncology
 2020-10-27
NCT03297359 TERMINATED
Cancer; Venous Thromboembolism; Obesity
Ottawa Hospital Research Institute
 2018-03-21 PHASE2
NCT05586854 UNKNOWN
Dialysis; Complications; Heparin-induced Thrombocytopenia; Chronic Renal Failure
GCS Ramsay Santé pour l'Enseignement et la Recherche
 2022-11-20
NCT04635241 COMPLETED
Covid19
Australian National University
 2020-06-01 PHASE2; PHASE3
NCT05239637 UNKNOWN
Extracorporeal Membrane Oxygenation
Second Affiliated Hospital of Zhengzhou University
 2022-02-15
NCT05707936 UNKNOWN
Port-a-cath Occlusion; Normal Saline; Heparin Lock
Chang Gung Memorial Hospital
 2023-02-01
NCT05329155 COMPLETED
STEMI; Primary PCI
Renmin Hospital of Wuhan University
 2022-07-20
NCT05788900 UNKNOWN
Anticoagulant
Blau Farmaceutica S.A.
 2023-06-01 PHASE1
NCT05304455 COMPLETED
Cirrhosis; Splenectomy; Venous Thrombosis; Hypertension, Portal
Northern Jiangsu People's Hospital
 2022-04-01
NCT06076434 COMPLETED
Stroke
Kastamonu University
 2022-11-01
NCT05029596 COMPLETED
Cancer
University of Texas Southwestern Medical Center
 2020-02-12 EARLY_PHASE1
NCT05998421 COMPLETED
Acupuncture; Recurrent Spontaneous Abortion; Ultrasound Therapy; Coagulation
Jianmei Xia
 2022-03-01
NCT05188339 UNKNOWN
Central Venous Catheter Thrombosis; Renal Dialysis
Chang Gung Memorial Hospital
 2022-07-20 PHASE2; PHASE3
NCT04485429 WITHDRAWN
COVID-19
D'Or Institute for Research and Education
 2020-07-20 PHASE3
NCT06367036 COMPLETED
Pain; Ecchymosis
Uskudar University
 2022-01-02
NCT04466618 COMPLETED
Healthy; Type 2 Diabetes
Adrian Vella
 2021-04-15 PHASE3
NCT04139525 UNKNOWN
End Stage Renal Disease; Haemodialysis; Anticoagulation
Marija Malgaj Vrečko
 2020-09-15
NCT02144064 UNKNOWN
Recurrent Pregnancy Loss
Benha University
 2019-06-23 PHASE3
NCT05742126 COMPLETED
Healthy
Haisco Pharmaceutical Group Co., Ltd.
 2022-04-11 PHASE1
NCT04215588 COMPLETED
Cardiopulmonary Bypass
Aristotle University Of Thessaloniki
 2019-12-20
NCT05681338 COMPLETED
Thyroidectomy; Colon Surgery; Cholecystectomy; Inguinal Hernia
Uludag University
 2022-03-17
NCT03324139 COMPLETED
Intrauterine Growth Restriction
Fundació Sant Joan de Déu
 2018-01-25 PHASE3
NCT04772209 COMPLETED
Catheter Blockage; Catheter-Related Infections; Dialysis Catheter; Thrombosis; Catheter Infection; Catheter Related Complication; Catheter Dysfunction
Zonguldak Ataturk State Hospital
 2021-02-01
NCT05237726 COMPLETED
Burns
King Abdullah International Medical Research Center
 2020-04-05
NCT02984384 COMPLETED
Blood Clot; Trauma
Major Extremity Trauma Research Consortium
 2017-04-24 PHASE3
NCT06505616 COMPLETED
End Stage Renal Disease on Dialysis
Fundación Senefro
 2022-01-17
NCT04741295 UNKNOWN
Adenomyosis; Assisted Reproductive Technology
Nanjing University
 2020-02-01
NCT04511923 COMPLETED
Covid19; ARDS, Human; Lung Injury, Acute; Ventilation Perfusion Mismatch
University College Hospital Galway
 2020-12-23 PHASE1; PHASE2
NCT04397510 TERMINATED
Covid-19; ARDS, Human; Acute Lung Injury
Frederick Health
 2020-06-01 PHASE4
NCT04466670 UNKNOWN
COVID-19
University of Sao Paulo General Hospital
 2020-07-11 PHASE2
NCT03148912 UNKNOWN
Heparin-induced Thrombocytopenia (HIT)
Ottawa Hospital Research Institute
 2018-11-23
NCT04743011 COMPLETED
Covid19
UPECLIN HC FM Botucatu Unesp
 2021-06-01 PHASE1; PHASE2
NCT05279391 UNKNOWN
COVID-19 Severe Respiratory Failure
Democritus University of Thrace
 2020-10-25
NCT03363035 COMPLETED
Acute Coronary Syndrome; Myocardial Infarction; Myocardial Ischemia; Unstable Angina
Second Xiangya Hospital of Central South University
 2018-01-15 PHASE4
NCT03772613 COMPLETED
Coronary Artery Disease; Ischemic Heart Disease; Anticoagulant-induced Bleeding; Coronary Syndrome
Mayo Clinic
 2019-02-08 PHASE2
NCT02981472 COMPLETED
Thrombosis
Bristol-Myers Squibb
 2017-01-19 PHASE2
NCT03318393 COMPLETED
Extracorporeal Membrane Oxygenation Complication; Pediatric ALL; Anticoagulants
University of Texas Southwestern Medical Center
 2018-03-25 PHASE4
NCT03752437 COMPLETED
Extracorporeal Circulation; Complications
Astes
 2019-10-01 PHASE4
NCT04707560 UNKNOWN
Endoscopic Ultrasonography; EUS-FNA; Pancreatic Neoplasms
National Cheng-Kung University Hospital
 2020-01-01
NCT04842292 TERMINATED
Covid19
Brittany Bissell
 2021-05-20 PHASE2
NCT04380818 UNKNOWN
Pneumonia, Viral
Grupo de Investigación Clínica en Oncología Radioterapia
 2020-06-05
NCT03671174 UNKNOWN
Undifferentiated Connective Tissue Disease; Recurrent Pregnancy Loss
RenJi Hospital
 2019-08-02
NCT04256525 UNKNOWN
Venous Thrombosis Due to Central Venous Access Device (Disorder); Prophylactic Anticoagulation; Patients With Tumor
Second Affiliated Hospital, Zhejiang University, School of Medicine
 2020-05-01 PHASE4
NCT04723563 COMPLETED
Covid19; Pneumonia, Viral
Frederick Health
 2021-02-22 PHASE4
NCT03090880 TERMINATED
Venous Thromboembolism; Lung Neoplasm
Assistance Publique - Hôpitaux de Paris
 2018-09-14 PHASE3
NCT04528888 UNKNOWN
Covid19; SARS-CoV Infection; Pneumonia, Viral; Coagulopathy
Massimo Girardis
 2020-11-25 PHASE3
NCT04419493 COMPLETED
Healthy
Boehringer Ingelheim
 2020-06-23 PHASE1
NCT06365398 COMPLETED
Cerebral Angiography; Heparinization
Xuanwu Hospital, Beijing
 2018-01-01 PHASE4
NCT03562754 COMPLETED
Hemodialysis
Centre Hospitalier Universitaire de Nīmes
 2019-03-11
NCT04372589 COMPLETED
COVID-19; Pneumonia
University of Manitoba
 2020-05-20 PHASE2; PHASE3
NCT04367831 COMPLETED
COVID-19; Venous Thromboses; Arterial Thrombosis
Columbia University
 2020-05-02 PHASE4
NCT02435732 UNKNOWN
Kidney Failure
University of Wisconsin, Madison
 2020-12 PHASE1
NCT06646328 TERMINATED
Acute Kidney Injury
Fernando Sanchez
 2018-06-09 PHASE4
NCT04764396 TERMINATED
Pancreas; Mass Lesion
University of Michigan
 2021-03-12
NCT04486508 COMPLETED
Covid19
Rajaie Cardiovascular Medical and Research Center
 2020-07-30 PHASE3
NCT04487990 COMPLETED
Acute Kidney Injury; Covid19
University of Sao Paulo General Hospital
 2020-06-29
NCT04394377 COMPLETED
Coronavirus Infection
Brazilian Clinical Research Institute
 2020-06-21 PHASE4
NCT04269954 UNKNOWN
Cerebral Venous Sinus Thrombosis; Batroxobin
Capital Medical University
 2020-03-01 PHASE4
NCT03125187 SUSPENDED
Heparin
União Química Farmacêutica Nacional S/A
 2021-02-20 PHASE1
NCT04865510 COMPLETED
Acute Kidney Injury; Citrate; Cytokines; Hemodynamic Responses
Bangkok Metropolitan Administration Medical College and Vajira Hospital
 2019-02-04
NCT04462614 UNKNOWN
Chronic Hemolysis; VKA; Anticoagulants / Administration & Dosage; Coated Materials; Biocompatible; Heparin / Administration & Dosage; Membranes Artificial; Prospective Studies; Renal Dialysis / Methods; Renal Insufficiency / Therapy
CHU de Reims
 2020-08
NCT04982055 COMPLETED
Critical Illness
Clinique Saint Pierre Ottignies
 2015-04-08 PHASE4
NCT03965208 UNKNOWN
Extracorporeal Membrane Oxygenation Complication; Anticoagulants
Legacy Health System
 2019-05-23 PHASE4
NCT04185077 UNKNOWN
STEMI - ST Elevation Myocardial Infarction
Second Xiangya Hospital of Central South University
 2019-11-30 PHASE4
NCT04394182 SUSPENDED
Pneumonia, Viral; Cytokine Storm
Fundacion GenesisCare
 2020-04-21
NCT04195997 UNKNOWN
Evaluate the Safety and Efficacy of Bivalirudin in Decreasing Bleeding Risk
Shanghai Zhongshan Hospital
 2020-02-01 PHASE4
NCT02379806 COMPLETED
Venous Thromboembolism
University Hospital, Brest
 2015-09-03 PHASE3
NCT04584580 UNKNOWN
Coronavirus Disease (COVID)19
Ain Shams University
 2020-08-01 PHASE4
NCT04530578 UNKNOWN
Covid19; Pneumonia
Clinica San Camilo, Argentina
 2020-06-01 PHASE4
NCT03894904 COMPLETED
Pediatrics; Anesthesia; Vasospasm
The University of Texas Health Science Center, Houston
 2019-04-01 PHASE4
NCT02529774 UNKNOWN
Resected Liver Metastases From Colorectal Cancer
Ye Xu
 2015-09 PHASE2; PHASE3
NCT04069429 COMPLETED
Eosinophilic Esophagitis
University of Utah
 2016-07 EARLY_PHASE1
NCT01220245 COMPLETED
Cardiovascular Diseases
Rijnstate Hospital
 2010-10
NCT04344756 UNKNOWN
COVID19 Pneumonia
Assistance Publique - Hôpitaux de Paris
 2020-04-20 PHASE2
NCT04046029 UNKNOWN
Acute Coronary Syndrome; Percutaneous Coronary Intervention; Aging; Anticoagulants and Bleeding Disorders
The First Affiliated Hospital of Dalian Medical University
 2019-07-08 PHASE4
NCT02834559 COMPLETED
Rhegmatogenous Retinal Detachment; High-risk for Proliferative Vitreoretinopathy (PVR)
Universitätsklinikum Köln
 2016-10-27 PHASE3
NCT03757481 COMPLETED
Post Thrombotic Syndrome; Deep Vein Thrombosis; Chronic Thromboembolic Pulmonary Hypertension
University Hospital, Montpellier
 2018-01-01
NCT04054128 UNKNOWN
End Stage Renal Disease; Vascular Access Complication; Catheter Complications; Hemodialysis Access Failure; Hemodialysis Catheter Infection
Hospital General "Dr. Miguel Silva" de Morelia
 2019-09-11 PHASE4
NCT03787641 UNKNOWN
Cardiac Surgery With Cardiopulmonary Bypass
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
 2018-09-20
NCT03350737 COMPLETED
Refractory Angina; Chronic Stable Angina
Clinical Centre of Serbia
 2013-02-01
NCT03633994 UNKNOWN
Lower Urinary Tract Symptoms; Postoperative Urinary Tract Infection
The Christ Hospital
 2018-08-20 PHASE2
NCT03672006 COMPLETED
Central Venous Catheter Thrombosis; Central Venous Catheter Associated Bloodstream Infection
Medical College of Wisconsin
 2019-04-22 PHASE2
NCT03483207 UNKNOWN
Mesenteric Vein Thrombosis
Assiut University
 2018-04-01
NCT03594045 TERMINATED
Heparin-induced Thrombocytopenia; Heparin-induced Thrombocytopenia and Thrombosis
Massachusetts General Hospital
 2018-12-18 PHASE2
NCT02986594 UNKNOWN
Thrombophilia With Recurrent Pregnancy Loss
Shanghai First Maternity and Infant Hospital
 2016-11 PHASE4
NCT03081169 WITHDRAWN
TBI (Traumatic Brain Injury); VTE (Venous Thromboembolism)
Loyola University
 2017-04-03 PHASE4
NCT03723187 COMPLETED
Cancer
Chang Gung Memorial Hospital
 2016-08-01
NCT02271295 SUSPENDED
Cirrhosis
Assistance Publique - Hôpitaux de Paris
 2015-07-27 PHASE3
NCT03516656 COMPLETED
Deep Vein Thrombosis; Pulmonary Embolism; Venous Thromboembolism
University of Utah
 2018-03-23 EARLY_PHASE1
NCT02583191 TERMINATED
Venous Thromboembolism; Cancer
AIO-Studien-gGmbH
 2016-03-23 PHASE3
NCT03171727 UNKNOWN
Liver Cirrhosis; Portal Hypertension
West China Hospital
 2017-06-01
NCT05223244 COMPLETED
Interstitial Cystitis; Painful Bladder Syndrome
Endeavor Health
 2011-10-01 PHASE4
NCT00432796 UNKNOWN
Stroke
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
 2006-12 PHASE3
NCT03591471 UNKNOWN
Henoch-Schönlein Purpura Nephritis
Henan University of Traditional Chinese Medicine
 2014-09 PHASE1; PHASE2
NCT03426982 UNKNOWN
Myocardial Infarction; Venous Thromboembolism; Stroke; Bleeding
Wuhan Asia Heart Hospital
 2018-03-01 PHASE4
NCT02651428 COMPLETED
Kidney Failure, Chronic; Catheter-Related Infections
CorMedix Therapeutics
 2015-12 PHASE3
NCT02334007 COMPLETED
Venous Thromboembolism; Lung Neoplasms; Pulmonary Embolism
McMaster University
 2015-09 PHASE1; PHASE2
NCT01084993 UNKNOWN
Coronary Artery Disease
Laval University
 2010-03 PHASE4
NCT03114722 UNKNOWN
Occlusion
National University Hospital, Singapore
 2017-07-31 PHASE2
NCT03143569 COMPLETED
Left Sided Heart Failure; Left Ventricular Assist Device; Anticoagulant Therapy; Gastro Intestinal Bleeding; Thrombosis, LVAD; Anti-factor Xa; aPTT; Heparin
Washington University School of Medicine
 2017-05-20
NCT02098993 TERMINATED
Acute Chest Syndrome; Sickle Cell Disease
Craig Seaman
 2014-05 PHASE2
NCT02591199 TERMINATED
Interstitial Cystitis; Bladder Pain Syndrome
Urigen
 2015-09 PHASE2
NCT02746185 COMPLETED
Neoplasm; Venous Thromboembolism
Assistance Publique - Hôpitaux de Paris
 2016-09 PHASE3
NCT02531165 COMPLETED
Acute Myocardial Infarction
Centre Hospitalier Universitaire Vaudois
 2015-09
NCT03465085 COMPLETED
Acute Respiratory Distress Syndrome; Severe Acute Respiratory Syndrome
Beni-Suef University
 2016-02-18 PHASE3
NCT02164097 TERMINATED
Recurrent Solid Tumor; Refractory Solid Tumor; Sarcoma; Wilms' Tumor; Neuroblastoma
New York Medical College
 2015-01 PHASE1
NCT02414802 UNKNOWN
Venous Thrombosis
Xuzhou Medical University
 2014-12
NCT02923830 TERMINATED
Obstruction; Catheter, Infusion Catheter (Vascular); Catheter; Complications (Indwelling Catheter)
TriHealth Inc.
 2016-04 PHASE4
NCT02970409 COMPLETED
Catheter-Related Infections
Hospital General Universitario Gregorio Marañon
 2015-10-17
NCT03000673 COMPLETED
Antithrombotic
Bristol-Myers Squibb
 2017-05-23 PHASE1; PHASE2
NCT02787317 UNKNOWN
Coronary Disease
Chinese PLA General Hospital
 2016-05 PHASE4
NCT03333395 COMPLETED
Mechanically Ventilated Patients
Ain Shams University
 2017-02-01 PHASE4
NCT02073682 COMPLETED
Venous Thromboembolism (VTE); Deep Vein Thrombosis (DVT); Pulmonary Embolism (PE); Cancer
Daiichi Sankyo
 2015-07-16 PHASE3
NCT04778917 COMPLETED
Pneumonia
Capital Institute of Pediatrics, China
 2014-12 PHASE4
NCT02036255 COMPLETED
Patency; Infection
Universitair Ziekenhuis Brussel
 2015-05 PHASE3
NCT03120715 UNKNOWN
Infertility
Nanfang Hospital, Southern Medical University
 2016-07-01 PHASE4
NCT02897037 UNKNOWN
Acute Myocardial Infarction
Shenzhen Salubris Pharmaceuticals Co., Ltd.
 2016-11 PHASE3
NCT02674906 COMPLETED
Intra Operative Bleeding, Blood Salvage
Ziekenhuis Oost-Limburg
 2016-02
NCT02910518 COMPLETED
Type1 Diabetes Mellitus
Sanofi
 2017-02-17 PHASE1
NCT02375646 UNKNOWN
Post Polypectomy Bleeding in Anticoagulated Patients; Gastrointestinal Hemorrhage
Hadassah Medical Organization
 2015-05
NCT02774265 COMPLETED
Venous Thromboembolism; Pulmonary Embolism
University of Maryland, Baltimore
 2016-01 PHASE3
NCT05771285 COMPLETED
Injection Site Bruising; Bruising; Pain
Yuksek Ihtisas University
 2017-01
NCT02890875 TERMINATED
Catheter-Related Infections
Stanford University
 2016-08
NCT02311231 COMPLETED
ST-segment Elevation Myocardial Infarction; Non ST-segment Elevation Myocardial Infarction
Uppsala University
 2014-06 PHASE4
NCT02326051 COMPLETED
Recurrent Miscarriage; Antiphospholipid Syndrome
Mohamed Sayed Abdelhafez
 2014-12 PHASE4
NCT02165761 TERMINATED
End Stage Renal Disease
W.L.Gore & Associates
 2014-07
NCT03233321 COMPLETED
Pain; Bruise
Maharishi Markendeswar University (Deemed to be University)
 2015-11
NCT02675647 COMPLETED
Cardiac Surgery; Cardiopulmonary Bypass; Obese Patients (BMI ≥ 30 kg/m²)
University Hospital, Strasbourg, France
 2015-12 PHASE4
NCT02785575 UNKNOWN
Cardiac Surgery; Bleeding; Transfusion; Protamine Sulfate; Heparin
Karolinska University Hospital
 2016-04 PHASE4
NCT01472965 COMPLETED
Central Line-Associated Bloodstream Infection
St. Jude Children's Research Hospital
 2011-12-29 PHASE3
NCT01823393 TERMINATED
Aortic Stenosis, Non-rheumatic
University Hospital, Montpellier
 2013-01-24 PHASE4
NCT01773083 TERMINATED
Inhalation Injury; Burn Injury
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
 2013-10 PHASE3
NCT02227329 TERMINATED
Catheter-related Bloodstream Infection (CRBSI) Nos; Bloodstream Infection Due to Central Venous Catheter; Bloodstream Infection Due to Hickman Catheter
Mayo Clinic
 2014-07 PHASE1; PHASE2
NCT01840683 COMPLETED
Non-exudative (Dry) Age-related Macular Degeneration (AMD)
B.Braun Avitum AG
 2013-05
NCT00475098 COMPLETED
Lung Cancer; Non Small Cell Lung Cancer
Assistance Publique - Hôpitaux de Paris
 2007-06 PHASE3
NCT02658838 UNKNOWN
LOVASTATIN/TICAGRELOR [VA Drug Interaction]
Beijing Anzhen Hospital
 2015-04 PHASE4
NCT03841396 COMPLETED
Injection Site Reaction
Aspen Global Incorporated
 2016-06-02 PHASE4
NCT01390051 COMPLETED
Fetal Growth Retardation
University of Aarhus
 2011-07 PHASE4
NCT02577718 COMPLETED
Catheter-Associated Infections; Catheter-Related Infections
Novel Anti-Infective Technologies, LLC
 2015-11 PHASE1; PHASE2
NCT02565147 TERMINATED
Acute Myocardial Infarction
The Medicines Company
 2014-12-19 PHASE3
NCT01315093 COMPLETED
Infertility
National and Kapodistrian University of Athens
 2010-11 PHASE2; PHASE3
NCT01318811 TERMINATED
Acute Kidney Injury; Acute Renal Failure; Heart Failure
Vanderbilt University
 2011-03 PHASE4
NCT01913483 TERMINATED
Peripheral Endovascular Interventions; Bleeding
The Medicines Company
 2013-09-24 PHASE3
NCT02604238 WITHDRAWN
Pulmonary Embolism
Azienda U.S.L. 1 di Massa e Carrara
 2016-03 PHASE3
NCT02159287 UNKNOWN
Embolic Stroke
Shiraz University of Medical Sciences
 2014-01 PHASE2
NCT02477072 COMPLETED
Peripheral Revascularisation
Centre hospitalier de l'Université de Montréal (CHUM)
 2015-09
NCT02497326 UNKNOWN
Second Degree Burns
King Edward Medical University
 2015-04
NCT01855516 COMPLETED
Thrombosis
Centre hospitalier de l'Université de Montréal (CHUM)
 2013-09
NCT01935557 COMPLETED
Coagulation; Intravascular
Yong Seog Oh
 2012-12 PHASE3
NCT02355873 COMPLETED
Critical Ill Patients; Patients Needing Continuous Renal Replacement Therapy
Peking University First Hospital
 2015-02 PHASE4
NCT01651780 COMPLETED
Severe Aortic Stenosis; Transcatheter Aortic Valve Replacement; Aortic Valve Replacement
The Medicines Company
 2012-10 PHASE3
NCT02240927 UNKNOWN
Pregnancy; Heart; Complications, Valve, Prosthesis
Kartal Kosuyolu Yuksek Ihtisas Education and Research Hospital
 2010-01
NCT02325479 COMPLETED
Infertility
The Egyptian IVF-ET Center
 2015-01 PHASE1
NCT01976988 COMPLETED
Venous Thromboembolism
Cedars-Sinai Medical Center
 2013-09 PHASE3
NCT02132689 COMPLETED
Pulmonary Embolism
University Hospital Ostrava
 2011-03 PHASE4
NCT01862978 UNKNOWN
Acute Ischemic Stroke
University Hospital, Martin
 2013-05 PHASE4
NCT01843634 COMPLETED
Acute Myeloid Leukemia
Jazz Pharmaceuticals
 2013-08 EARLY_PHASE1
NCT01648712 TERMINATED
Acquired Platelet Function Disorder
Hôpital Necker-Enfants Malades
 2013-03
NCT02991950 TERMINATED
Infertility; Low Molecular Weight Heparin
Istituto Clinico Humanitas
 2011-07 PHASE3
NCT02056782 COMPLETED
Acute Myeloid Leukemia
Jazz Pharmaceuticals
 2013-12 PHASE1
NCT01817257 TERMINATED
Cancer; Thrombosis; Venous Thromboembolism; Deep Vein Thrombosis; Pulmonary Embolus
Cardiff University
 2013-12 PHASE2
NCT01363193 UNKNOWN
Obesity; Morbid Obesity; Venous Thromboembolism; Atrial Fibrillation; Angina; Chest Pain
Nazareth Hospital
 2011-07
NCT02348190 COMPLETED
Other Fatty Acid Oxidation Disorders; Diabetes Mellitus; Insulin Resistance
Temple University
 2003-06
NCT01598883 COMPLETED
Cardiopulmonary Bypass; Altered Heparin Response
Massachusetts General Hospital
 2012-06 PHASE1
NCT01970280 UNKNOWN
Hemodialysis Patients
Dr. Sidney Ben Chetrit
 2013-09 PHASE4
NCT01989091 TERMINATED
Dialysis Catheter Infections
Great Lakes Pharmaceuticals Inc.
 2012-07 PHASE3
NCT02026765 COMPLETED
Inflammatory Reaction
Wenzhou Medical University
 2013-11
NCT01780987 COMPLETED
Deep Vein Thrombosis; Pulmonary Embolism
Pfizer
 2013-01 PHASE3
NCT01729559 COMPLETED
Venous Thromboembolic Disease; Deep Vein Thrombosis; Pulmonary Embolism
Scripps Health
 2012-11 PHASE4
NCT01794767 SUSPENDED
Infection of Intravenous Catheter; Phlebitis; Extravasation of Diagnostic and Therapeutic Materials
University of Florence
 2013-01 PHASE4
NCT01164046 TERMINATED
Venous Thromboembolism; Neoplasms
University Medical Center Groningen
 2010-08 PHASE3
NCT02135770 COMPLETED
Severe Sepsis With Septic Shock; Severe Sepsis Without Septic Shock
Indonesia University
 2013-01 PHASE3
NCT01382888 TERMINATED
Haemodialysis
Cyathus Exquirere Pharmaforschungsgmbh
 2011-07 PHASE2
NCT01532544 TERMINATED
Pneumonia
Thrombologic ApS
 2012-06 PHASE2
NCT01547728 TERMINATED
Thrombophilia Due to Acquired Antithrombin III Deficiency
Mayo Clinic
 2012-02 PHASE4
NCT01274637 COMPLETED
Venous Thromboembolism; Postpartum
Ottawa Hospital Research Institute
 2011-03 PHASE3
NCT01662908 COMPLETED
Deep Vein Thrombosis; Venous Thrombosis
Daiichi Sankyo
 2012-08 PHASE2
NCT01626911 UNKNOWN
Acute Pancreatitis
Nanjing University School of Medicine
 2011-09
NCT01956955 UNKNOWN
This Study Will Provide Data Comparing Safety of LMWH Versus UFH in the Treatment of Acute PE Cases Who Require Thrombolytic Treatment.
Ataturk University
 2011-01 PHASE4
NCT01029821 UNKNOWN
Deep Venous Thrombosis
University of Tennessee
 2010-02
NCT01516840 COMPLETED
Deep Vein Thrombosis
Bayer
 2012-03 PHASE3
NCT01520454 COMPLETED
Obesity; Leptin Resistance
Beth Israel Deaconess Medical Center
 2011-11
NCT01917799 UNKNOWN
Pregnancy; Miscarriage
University of Khartoum
 2009-01 PHASE4
NCT01692158 COMPLETED
Healthy
Azidus Brasil
 2013-03 PHASE1
NCT02094157 TERMINATED
Cardiac Arrhythmias; Hemorrhage; Thromboembolism
McMaster University
 2007-12 PHASE3
NCT01692171 COMPLETED
Healthy
Azidus Brasil
 2013-02-28 PHASE1
NCT01356992 TERMINATED
Non ST Segment Elevation Myocardial Infarction; Unstable Angina
Eurofarma Laboratorios S.A.
 2012-07 PHASE3
NCT01696110 COMPLETED
Acute Myocardial Infarction; Percutaneous Coronary Intervention
Shenyang Northern Hospital
 2012-08 PHASE4
NCT00789308 COMPLETED
Diabetes Mellitus, Type I
National Institute of Allergy and Infectious Diseases (NIAID)
 2008-07-11 PHASE2
NCT01651923 UNKNOWN
Healthy
Azidus Brasil
 2013-02 PHASE1
NCT01652638 UNKNOWN
Healthy
Azidus Brasil
 2013-02 PHASE1
NCT00800137 TERMINATED
Hematoma
Ottawa Heart Institute Research Corporation
 2008-12 PHASE4
NCT00489437 COMPLETED
Heparin-Induced Thrombocytopenia
McMaster University
 2007-12 PHASE1
NCT01466959 COMPLETED
Chronic Kidney Disease
University of Calgary
 2011-11
NCT01589146 UNKNOWN
The Primary Study Objective is to Assess the Efficacy and; Safety of Extended 4-week Heparin Prophylaxis Compared to; Prophylaxis Given for 8±2 Days After Planned Laparoscopic; Surgery for Colorectal Cancer.; The Clinical Benefit Will be Evaluated as the Difference in; the Incidence of VTE or VTE-related Death Occurring Within 30 Days; From Surgery in the Two Study Groups.
University Of Perugia
 2010-09 PHASE3
NCT01694459 UNKNOWN
Stable Angina; Angina, Unstable; Non-ST Elevation (NSTEMI) Myocardial Infarction
San Filippo Neri General Hospital
 2010-01 PHASE4
NCT01461915 TERMINATED
Metastatic Pancreatic Cancer
Jazz Pharmaceuticals
 2011-11 PHASE2
NCT01465503 COMPLETED
Bleeding
Clinica Mediterranea
 2008-01 PHASE3
NCT00771563 COMPLETED
Non-Small Cell Lung Cancer
University Hospital, Antwerp
 2008-06 PHASE3
NCT00735813 COMPLETED
Bacteremia; Neoplasms
Aarhus University Hospital
 2008-04 PHASE3
NCT01454869 WITHDRAWN
Heparin
Tehran University of Medical Sciences
 2012-02 PHASE3
NCT01086046 UNKNOWN
Thrombosis
Third Military Medical University
 2009-01
NCT01312935 TERMINATED
Percutaneous Coronary Intervention; Coronary Artery Disease (CAD); Angioplasty
PolyMedix, Inc.
 2011-04 PHASE2
NCT00882635 COMPLETED
Acute Myocardial Infarction
Robert Welsh
 2008-10 PHASE3
NCT01645774 TERMINATED
Pain; Bruising
Mashhad University of Medical Sciences
 2011-01 PHASE2; PHASE3
NCT01070875 COMPLETED
Thrombosis
Centre hospitalier de l'Université de Montréal (CHUM)
 2010-04
NCT00209378 COMPLETED
Acute Kidney Injury
Universitair Ziekenhuis Brussel
 2005-05
NCT01343680 TERMINATED
Childhood Cancer; Aplastic Anemia; Metabolic Disorders
Alberta Children's Hospital
 2011-04 PHASE3
NCT01112371 COMPLETED
Scars
Merz Pharmaceuticals GmbH
 2011-02 PHASE4
NCT01513200 COMPLETED
Healthy Volunteers
Stealth BioTherapeutics Inc.
 2012-01 PHASE1
NCT01229592 TERMINATED
Catheter Related Infection
Hospital General Universitario Gregorio Marañon
 2009-12
NCT01228292 UNKNOWN
Acute Kidney Injury; Hemodialysis
University Hospital, Antwerp
 2011-01 PHASE4
NCT01019655 UNKNOWN
Pregnancy and Thrombophilia
Medical University of Vienna
 2010-01 PHASE3
NCT01050153 COMPLETED
Venous Thromboembolism
Denver Health and Hospital Authority
 2010-03
NCT01346215 UNKNOWN
Chronic Renal Failure
Laboratório Químico Farmacêutico Bergamo Ltda.
 2011-10 PHASE3
NCT00894829 COMPLETED
Cardiac Surgery
Azidus Brasil
 2009-06 PHASE3
NCT01343381 COMPLETED
Coronary Artery Disease
McMaster University
 2011-06 PHASE4
NCT00673439 TERMINATED
Heparin-Induced Thrombocytopenia
University of Louisville
 2007-11 PHASE2
NCT01246011 TERMINATED
Coronary Artery Bypass Graft Surgery; Presence of Heparin/Platelet Factor 4 Antibody
Massachusetts General Hospital
 2010-11 PHASE4
NCT00994136 COMPLETED
Oncology, Medical; Hematologic Disease
Universitaire Ziekenhuizen KU Leuven
 2009-01 PHASE4
NCT00680459 TERMINATED
Bloodstream Infection
Baystate Medical Center
 2008-05 PHASE3
NCT00373451 COMPLETED
Myocardial Infarction; Coronary Disease
Deutsches Herzzentrum Muenchen
 2006-07 PHASE4
NCT00879957 WITHDRAWN
Infant, Premature; Anticoagulants; Thrombosis
The University of Texas Health Science Center at San Antonio
 2010-01
NCT00928213 UNKNOWN
Preeclampsia
Ben-Gurion University of the Negev
 2009-08 PHASE2; PHASE3
NCT01634438 COMPLETED
Coronary Angiograph
University of Alberta
 2008-07 PHASE4
NCT01094886 COMPLETED
Arthritis; Osteoarthritis, Knee; Osteoarthritis, Hip; Thromboembolism
Ortho-McNeil Janssen Scientific Affairs, LLC
 2010-03 PHASE3
NCT00464087 COMPLETED
Acute Coronary Syndromes
Medstar Health Research Institute
 2007-06 PHASE3
NCT00934167 UNKNOWN
Venous Thromboembolism
Azidus Brasil
 2010-05 PHASE2; PHASE3
NCT00818753 COMPLETED
Heart Catheterization
Boehringer Ingelheim
 2009-01 PHASE2
NCT00790907 COMPLETED
Acute Coronary Syndrome
GlaxoSmithKline
 2009-02 PHASE4
NCT00718471 COMPLETED
Primary PCI - STEMI
Assistance Publique - Hôpitaux de Paris
 2008-08 PHASE3
NCT00571259 COMPLETED
Bacteremia
Satellite Healthcare
 2003-09 PHASE4
NCT00718354 COMPLETED
Gastric Cancer; Gastroesophageal Cancer
Thrombosis Research Institute
 2008-07 PHASE3
NCT00199602 COMPLETED
Cancer
University Hospital, Limoges
 1999-08 PHASE3
NCT00911157 COMPLETED
Thrombosis, Venous
GlaxoSmithKline
 2008-06 PHASE3
NCT00790439 WITHDRAWN
Diabetes Mellitus, Type I
National Institute of Allergy and Infectious Diseases (NIAID)
 2008-07 PHASE2
NCT00894998 COMPLETED
Cardiac Surgery
Azidus Brasil
 2009-06 PHASE3
NCT00894959 COMPLETED
Cardiac Surgery
Azidus Brasil
 2009-07 PHASE3
NCT01214772 COMPLETED
Pregnancy; Thrombophilia
Yazd Medical University
 2009-05 PHASE4
NCT00794560 COMPLETED
Thromboembolism
University Hospital, Basel, Switzerland
 2007-06 PHASE4
NCT00457951 TERMINATED
Chronic Obstructive Pulmonary Disease
Jazz Pharmaceuticals
 2007-04 PHASE2
NCT00451412 COMPLETED
Thromboembolism
Novartis
 2007-01 PHASE3
NCT00543400 COMPLETED
Coronary Artery Disease (CAD)
Momenta Pharmaceuticals, Inc.
 2007-09 PHASE2
NCT00473109 COMPLETED
Contra-Indication to the Use of Low Molecular Weight Heparin
Assistance Publique - Hôpitaux de Paris
 2007-05 PHASE3
NCT00450645 UNKNOWN
Deep Vein Thrombosis; Cancer
Azienda Ospedaliera Universitaria Policlinico
 2005-03 PHASE4
NCT00614679 COMPLETED
End-Stage Renal Disease; Hemodialysis Catheter-associated Infection
University of California, San Diego
 2006-10 PHASE1
NCT00435487 TERMINATED
Angina, Unstable; Myocardial Infarction
Pfizer
 2007-06 PHASE4
NCT00329433 COMPLETED
Deep Venous Thrombosis
Washington University School of Medicine
 2006-05 PHASE2; PHASE3
NCT00526058 COMPLETED
Hypercholesterolemia
B. Braun Medical Inc.
 2007-08
NCT00358735 COMPLETED
Deep Vein Thrombosis of Lower Limb; Pulmonary Embolism (PE); Bleeding
Medical Compression Systems
 2006-06
NCT00494156 WITHDRAWN
Carotid Artery Injury; Vertebral Artery Injury
C. Clay Cothren, MD
 2003-07
NCT01229072 SUSPENDED
Chronic Renal Failure
Azidus Brasil
 2008-07 PHASE2; PHASE3
NCT00628680 UNKNOWN
End Stage Renal Disease
Ash Access Technology
 2006-07 PHASE3
NCT00448461 COMPLETED
Coronary Artery Disease
Careggi Hospital
 2007-03 PHASE4
NCT00669721 UNKNOWN
Renal Failure; Hemodialysis
IRCCS Azienda Ospedaliero-Universitaria di Bologna
 2008-03
NCT00618579 COMPLETED
Healthy
ThromboGenics
 2008-02 PHASE1
NCT00433966 COMPLETED
Myocardial Infarction
Cardiovascular Research Foundation, New York
 2005-03 PHASE3
NCT00701623 WITHDRAWN
Burns
Azidus Brasil
 2008-06 PHASE2; PHASE3
NCT00750451 COMPLETED
Infertility; Fertilization in Vitro; Recurrent Implantation Failure
V.K.V. American Hospital, Istanbul
 2006-01
NCT00473603 COMPLETED
Hyperandrogenism; Glucocorticoid Metabolism
Charite University, Berlin, Germany
 2006-12
NCT00828776 COMPLETED
Chronic Renal Failure
Azidus Brasil
 2007-09 PHASE2; PHASE3
NCT00262054 COMPLETED
Coronary Disease; Angina Pectoris
Deutsches Herzzentrum Muenchen
 2005-11 PHASE4
NCT00133250 COMPLETED
Myocardial Infarction
Deutsches Herzzentrum Muenchen
 2003-06 PHASE4
NCT00848796 COMPLETED
Coronary Artery Bypass Grafting
Southlake Health
 2006-09
NCT00629733 COMPLETED
Healthy
Rovi Pharmaceuticals Laboratories
 2007-12 PHASE1
NCT00311753 COMPLETED
Embolism
Novartis Pharmaceuticals
 2006-02 PHASE3
NCT00681785 COMPLETED
Thrombophylaxis in Transurethral Surgery
University Hospital, Basel, Switzerland
 2006-06
NCT00779558 COMPLETED
Thrombosis
Stanford University
 2005-11
NCT00377091 WITHDRAWN
Pulmonary Embolism
University of Minnesota
 2007-06 PHASE4
NCT00587444 COMPLETED
Postoperative Hemorrhage
Mayo Clinic
 2001-06 PHASE3
NCT00386451 COMPLETED
Neoplasms
University Hospital, Ghent
 2006-11
NCT00951574 COMPLETED
Advanced Cancer; Metastatic Cancer
Italfarmaco
 2003-10 PHASE3
NCT00252005 COMPLETED
Deep-Vein Thrombosis
Bristol-Myers Squibb
 2005-11 PHASE2
NCT00361348 COMPLETED
Healthy Volunteers
Swedish Orphan Biovitrum
 2005-12 PHASE1
NCT00198588 COMPLETED
Heparin-Induced Thrombocytopenia
Ministry of Health, Labour and Welfare, Japan
 2005-06 PHASE3
NCT00796692 COMPLETED
Pulmonary Embolism; Thromboembolism; Vascular Diseases; Thrombosis
Beijing Chao Yang Hospital
 2002-06 PHASE4
NCT00067093 COMPLETED
Deep Vein Thrombosis
Sanofi
 2003-05 PHASE3
NCT00077844 COMPLETED
Percutaneous Coronary Intervention
Sanofi
 2004-01 PHASE2; PHASE3
NCT00420667 COMPLETED
Coronary Disease; Coronary Artery Bypass Grafting
G. d'Annunzio University
 2004-11
NCT00077818 COMPLETED
Acute Coronary Syndrome
Sanofi
 2002-06 PHASE4
NCT00628576 COMPLETED
Deep Venous Thrombosis
Aalborg University Hospital
 1993-10 PHASE3
NCT00577096 COMPLETED
Multiple Myeloma
University of Arkansas
 2001-10
NCT01945879 COMPLETED
Pancreatic Cancer
CONKO-Studiengruppe
 2003-01 PHASE1; PHASE2
NCT00251576 COMPLETED
Acute Coronary Syndrome
Organon and Co
 1999-11-01 PHASE3
NCT00043940 COMPLETED
Heparin-Induced Thrombocytopenia; Thrombosis
The Medicines Company
 1999-04 PHASE3
NCT02181998 COMPLETED
Myocardial Infarction
Boehringer Ingelheim
 2000-07 PHASE3
NCT02181985 COMPLETED
Myocardial Infarction
Boehringer Ingelheim
 2000-05 PHASE3
NCT01713309 COMPLETED
Acute Respiratory Failure; Critically Ill
Helsinki University Central Hospital
 1996-01 PHASE2; PHASE3
NCT00427310 COMPLETED
Colorectal Cancer
NSABP Foundation Inc
 1984-03 PHASE3
NCT00238667 COMPLETED
Cervical Artery Dissection; Carotid Artery Dissection; Vertebral Artery Dissection; Stroke
St George's, University of London
 2005-11 PHASE3
NCT00000119 UNKNOWN
Cataract; Uveitis
National Eye Institute (NEI)
 1994-03 PHASE2
NCT00182364 COMPLETED
Critically Ill; Deep Venous Thrombosis
Hamilton Health Sciences Corporation
 2003-02 PHASE3
NCT00000472 COMPLETED
Angina Pectoris; Cardiovascular Diseases; Coronary Disease; Heart Diseases; Myocardial Infarction; Myocardial Ischemia
National Heart, Lung, and Blood Institute (NHLBI)
 1989-04 PHASE3
NCT00395824 COMPLETED
Dialysis
Universitaire Ziekenhuizen KU Leuven
 2005-01 PHASE3
NCT00242398 UNKNOWN
Kidney Failure; Critically Ill; Hemorrhage
Centre Hospitalier Départemental
 2005-10 PHASE3
NCT00203580 COMPLETED
Thrombosis; Thromboembolism; Venous Thrombosis
University of Calgary
 1994-12 PHASE4
NCT00196417 UNKNOWN
Heparin-Induced Thrombocytopenia
University Medicine Greifswald
 2003-01 PHASE4
NCT00074620 COMPLETED
Chronic Kidney Failure; Vascular Graft Occlusion
Speedel Pharma Ltd.
 2003-11 PHASE2
NCT00395772 COMPLETED
Venous Thromboembolism
Bayer
 2004-12 PHASE2
NCT00135863 TERMINATED
Inflammation; Nutrition; Peritoneal Dialysis
Ribe County Hospital
 2004-05
NCT00474591 UNKNOWN
Coronary Bypass Graft Failure/Occlusion
Hamilton Health Sciences Corporation
 PHASE3
NCT00637468 TERMINATED
Retinal Artery Occlusion; Fibrinolysis; Visual Acuity; Stroke; Hemodilution
University Hospital Freiburg
 2002-09 PHASE3
NCT00093158 COMPLETED
Unstable Angina; Myocardial Infarction; Acute Disease
The Medicines Company
 2003-08 PHASE3
NCT00484822 TERMINATED
Long-term Oral Anticoagulant Therapy
Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
 2007-02 PHASE3
NCT00439855 COMPLETED
Coronary Artery Disease
Triemli Hospital
 2003-09 PHASE4
NCT00187408 COMPLETED
Deep Vein Thrombosis; Pulmonary Embolism
Sunnybrook Health Sciences Centre
 2002-08 PHASE4
NCT00225108 COMPLETED
Deep Vein Thrombosis
Ottawa Hospital Research Institute
 2002-07 PHASE2; PHASE3
NCT00378781 WITHDRAWN
Cancer
M.D. Anderson Cancer Center
NCT00001311 COMPLETED
Cataracts
National Eye Institute (NEI)
 1992-04 PHASE2
NCT00133731 COMPLETED
Angioplasty, Transluminal, Percutaneous Coronary
Sanofi
 2004-09 PHASE2
NCT00370760 UNKNOWN
Proliferative Vitreoretinopathy
Shahid Beheshti University of Medical Sciences
 2006-09 PHASE3
NCT00381511 COMPLETED
Pulmonary Embolism
Azienda Ospedaliera Universitaria Policlinico
 1999-01 PHASE4
NCT00170378 COMPLETED
Brain Injury; Venous Thrombosis
Hennepin Healthcare Research Institute
 2002-12 PHASE4
NCT00413738 COMPLETED
Infection
Centre National de Greffe de Moelle Osseuse
 2006-12 PHASE3
NCT00233779 COMPLETED
Coronary Artery Disease
Cordis US Corp.
 2003-10 PHASE2
NCT00001713 COMPLETED
Embolism; Thrombophlebitis
National Institutes of Health Clinical Center (CC)
 1998-02 PHASE1

(data from https://clinicaltrials.gov, updated on 2026-07-27)

Check the Heparin product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Compliance for Clinical Use

Mechanism and Biochemical Profile

Heparin binds to antithrombin III to accelerate its inactivation of key coagulation proteases, particularly thrombin and Factor Xa, which suppresses downstream fibrin formation and thrombus propagation. This targeted inhibition of the clotting cascade prevents systemic intravascular thrombosis, providing direct therapeutic efficacy in managing thromboembolic disorders such as pulmonary embolism and acute coronary syndrome evaluated in clinical trials.

Appendix RUO and cGMP Quality Standards

Quality Dimension RUO (Research Use Only) cGMP (Current Good Manufacturing Practice)
Clinical Applicability Prohibited in human clinical trials or medical diagnostics. Mandatory for human clinical trials (Phase I–III) and therapies.
Regulatory Status Non-regulated grade; exempt from drug manufacturing laws. Legally enforced by health authorities (e.g., FDA, EMA, NMPA).
Facility Environment Unclassified analytical or research laboratories. Validated Cleanrooms (ISO Class 5–8) with continuous monitoring.
Quality Control Basic purity and activity testing. Rigorous safety release testing (Sterility, Endotoxin, Mycoplasma).
Process Validation Basic equipment calibration; no process validation required. Full qualification (IQ/OQ/PQ) and complete batch records.
Quality Assurance Vendor self-declared without required formal QMS. Mandatory QA/QC unit, Change Control, CAPA, and vendor audits.
Regulatory Impact High risk of IND rejection if used as a critical raw material. Required for IND/NDA filings, supported by Drug Master Files (DMF).

Footnotes

Regulatory Note: Governed by FDA (21 CFR Parts 210/211/312), EMA (EudraLex Vol 4), ICH Guidelines (E6/Q7/Q9/Q10), and compendial standards (USP <71>/<85>/<1043>).

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Note: Technical data last updated: Sep 1, 2026.