GSK126 is a highly selective EZH2 inhibitor. It affects Rho/ROCK, Notch, and AMPK/PPAR-γ signaling by decreasing H3K27me3 levels to modulate epigenetic transcription, effectively inhibiting tumor proliferation and fibrosis, while promoting apoptosis.
GSK126 IC50 for Cell-based and Cell-free Assays
Comprehensive IC50 Values for GSK126 Across Cell-free Enzyme Inhibitory Profiles and Cell-based Functional Assays.