SMILES:

CNC(=O)C1=CC=CC=C1NC2=NC(=NC=C2C)NC3=CC=CC(=C3)C[S](C)(=O)=O
GSK-1520489A Chemical Structure
Chemical Structure
Check the GSK-1520489A product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name N-methyl-2-[[5-methyl-2-[3-(methylsulfonylmethyl)anilino]pyrimidin-4-yl]amino]benzamide
CAS Number 1042433-41-9
Molecular Formula

C21H23N5O3S
Molecular Weight (MW) 425.5
SMILES CNC(=O)C1=CC=CC=C1NC2=NC(=NC=C2C)NC3=CC=CC(=C3)C[S](C)(=O)=O
InChIKey AKHLCKMEVWGDGL-UHFFFAOYSA-N

How to Prepare Stock Solution?

Concentration Volume Mass
🧮 Molarity Calculator

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 11 mg/mL (25.85 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.