CAS No. 1042433-41-9
Batch:
Purity:99.23
Chemical Structure
Check the
GSK-1520489A
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N-methyl-2-[[5-methyl-2-[3-(methylsulfonylmethyl)anilino]pyrimidin-4-yl]amino]benzamide | |
|---|---|---|
| CAS Number | 1042433-41-9 | |
| Molecular Formula |
C21H23N5O3S |
|
| Molecular Weight (MW) | 425.5 | |
| SMILES | CNC(=O)C1=CC=CC=C1NC2=NC(=NC=C2C)NC3=CC=CC(=C3)C[S](C)(=O)=O | |
| InChIKey | AKHLCKMEVWGDGL-UHFFFAOYSA-N |
GSK-1520489A is an active small-molecule inhibitor targeting protein kinase, membrane-associated tyrosine/threonine 1 (PKMYT1). By directly inhibiting PKMYT1 kinase activity, the compound disrupts G2/M cell cycle checkpoint regulation through the suppression of inhibitory CDK1 phosphorylation. Downstream functional consequences include dysregulated cell cycle progression, compromised cell cycle arrest mechanisms, and decreased cancer cell proliferation and survival. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
11 mg/mL
(25.85 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.