Home Biosimilar Antibodies Immunology & Inflammation TNF-alpha Golimumab (Anti-TNFSF2 / TNFa)
For research use only. Not for use in humans.

Golimumab (Anti-TNFSF2 / TNFa)

Synonyms: Tnf,TNF alpha

Golimumab (Anti-TNFSF2 / TNFa) is a human monoclonal antibody directed against the pro-inflammatory cytokine tumor necrosis factor-alpha (TNF-a) with immunosuppressive activity. MW: 146.94 KD.

Golimumab (Anti-TNFSF2 / TNFa)

Quality Control

Batch: A289201 Purity: 99% Protein concentration: 3.54mg/ml Endotoxin Level: ＜1EU/mg
99

Specificity

Name Citation TNF-α TNF-alpha Others
QNZ (EVP4593) 156 NF-κB
JTE-607 Dihydrochloride 2 IL-1beta,IL-8,IL-6
PF-3644022 2 MK2
UCB-9260 0 NF-κB
MD2-TLR4-IN-1 2 TLR4,IL-6
R-7050 11 IL-1β
Resatorvid (TAK-242) 65 TLR4,IL-6,NO
Apigenin-7-O-glucuronide 0
UTL-5g 0
Benpyrine racemate 1
Amarogentin 0 TAS2R1,AMPK
Stylopine 0 IL-1β,NO,COX-2
Myrislignan 1 iNOS,IL-6,NF-κB
NE 52-QQ57 2 iNOS,IL-6,IL-1β
(3R,8S)-Falcarindiol 3 IL-1β,IL-6,iNOS
Gardenoside 1 NF-κB,P2X7 Receptor,IL-6
Cucurbitacin IIb 1 JNK,STAT3,NF-κB
IQ 3 1 IL-6,JNK3,JNK1
Isuzinaxib (APX-115 free base) 2 IL-6,MCP-1/CCL2,NOX2
AUDA 1 Smad3,TGF-β,IL-1β
CPI-1189 1
Madecassic acid 3 IL-1β,COX-2,iNOS
Homoplantaginin 1 IL-6,IKKβ,NF-κB
2',5'-Dihydroxyacetophenone 1 IL-6,NF-κB,ERK1/2
Forsythoside B 0 IκB,NF-κB,IL-6
Mulberroside A 0 ERK,NF-κB,Caspase-1
Ginsenoside Rb1 4 TLR3,NF-κB,IRAK-1
Muscone 4 IL-6,IL-1β,NLRP3 inflammasome
(Rac)-Shikonin 44 NF-κB,Proteasome,chemokine receptor
Methylthiouracil 1 IL-6,ERK1/2,NF-κB
Expand to Check More
1. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation. 2. "✔" indicates inhibitory effect, but without specific value.

Mechanism of Action

Description
Golimumab (Anti-TNFSF2 / TNFa) is a human monoclonal antibody directed against the pro-inflammatory cytokine tumor necrosis factor-alpha (TNF-a) with immunosuppressive activity. MW: 146.94 KD.
References

Product Details

CAS No. 476181-74-5
Molecular Weight 146.94
Isotype Human IgG1
Source CHO
Purification AKTA
Sterility 0.2 μM filtered
Formulation 100 mM Pro-Ac, 20mM Arg, pH5.0
Storage
(From the date of receipt)		 Store the undiluted solution at -20°C in the dark to avoid freeze-thaw cycles.

Comparison of Clones for

*Literature analysis of various clone (for this target) products available on the market shows that Selleck's selected clones are more frequently applied. (data until September 2024)

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT07683026 NOT_YET_RECRUITING Drug: Golimumab|Drug: Placebo (matching golimumab) Type 1 Diabetes (T1D) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) 2026-08-08 PHASE2
NCT03414502 RECRUITING Drug: Methotrexate|Drug: Abatacept|Drug: Adalimumab|Drug: Az Rheumatoid Arthritis University of Nebraska 2007-12-10 PHASE3
NCT07138898 RECRUITING Drug: Methotrexate|Drug: Sulfasalazine|Drug: Hydroxychloroqu Rheumatic Disease NYU Langone Health 2025-12-12 PHASE2
NCT04729296 WITHDRAWN Drug: Golimumab|Drug: Placebo Diabetes Mellitus, Type 1 National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) 2021-07-01 PHASE2
NCT07137598 RECRUITING Drug: Afimkibart|Drug: Placebo Rheumatoid Arthritis Hoffmann-La Roche 2025-12-05 PHASE2
NCT05689879 ACTIVE_NOT_RECRUITING Drug: STOP arm Sarcoidosis Assistance Publique - Hôpitaux de Paris 2023-03-23 PHASE3

(data from https://clinicaltrials.gov, updated on 2026-07-06)

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Handling Instructions

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